DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dyrk3 and CG7028

DIOPT Version :9

Sequence 1:	NP_001033810.1	Gene:	Dyrk3 / 3885567	FlyBaseID:	FBgn0027101	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001286884.1	Gene:	CG7028 / 38032	FlyBaseID:	FBgn0027587	Length:	912	Species:	Drosophila melanogaster

Alignment Length:	469	Identity:	121/469 - (25%)
Similarity:	212/469 - (45%)	Gaps:	65/469 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 SPSKTKDVPGLFLRTISENSKSKSEPECESLISVKESSVMENHTFLFHEQIIMSGQQKCELHEKP 204
            :||.|...|...:..|.::.:.......:...|.||.   .|...:|.:|.:.|   ..::..|
  Fly   494 TPSPTMPCPNPLISEIPKDREDMDNSTSQKTCSAKEK---RNEWDMFADQDVDS---NFDVSRK- 551

  Fly   205 KVLVVSPQQVMILYMNKLTPYERTEILTYPQIYFIGANAKKRPGVYGPNNSEYDNEQGAYIHVPH 269
                :||..::   .||                    :..:.|.:    ...:|:.:|.|.....
  Fly   552 ----ISPNTIV---QNK--------------------HQHENPAL----TDNWDDAEGYYRVRIG 585

  Fly   270 DHVAYRYEMLKIIGKGSFGQVIKAYDH-KTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKY 333
            :.:..||.:....|:|.|..|::..|. :...:||:||:||.:..|:....|:.||..|...|..
  Fly   586 EVLDNRYLVNGYTGQGVFSNVVRGRDQARGQANVAIKIIRNNEIMHKTGLRELEILKKLNDADPE 650

  Fly   334 NTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFK-GFSLQLVRKFAHSLLQCLDALYKND 397
            :..:.:.::.:|..:.|.|:.||.|::||.|::||.|.. |..::.||.:...|...|..|.|..
  Fly   651 DRFHCLRLYRHFFHKQHLCMVFEPLAMNLREVLKKYGKNVGLHIKAVRSYTQQLFLALKLLKKTG 715

  Fly   398 IIHCDMKPENVLLKQQGRSGIKVIDFGS-SCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWS 461
            |:|.|:||:|:|:.:.... :|:.|||| |...:..|..|:.|||||:||:|||..|...||.||
  Fly   716 ILHADIKPDNILVNENNLI-LKLCDFGSASAISDNEITPYLVSRFYRSPEIILGIPYDYGIDTWS 779

  Fly   462 LGCILAELLSGHALFPGENESDQLACIIEVLG-MPNKNILASSKRSKSFFSPKGYPRYCTV---- 521
            .||.:.||.:|..||.|::.:..|...::|.| :||:.|      .|..|..:.:.:.|..
  Fly   780 AGCTIYELYTGKILFSGKSNNQMLKFFMDVKGKIPNRII------RKGQFREQHFDQSCNFLYHE 838

  Fly   522 ---RTMSDGMVVLIGGQSRRGKQRGPPCSKSL----SKALDGCKDPLFLNFIRGCLEWDADKRLT 579
               .|..:.:||:...:..|..|:.....::|    .:.:...||     .:......|..||::
  Fly   839 IDKLTEREKIVVMPVVKPSRSLQQELIADQNLPDDQHRKVTQLKD-----LLENMFALDPAKRIS 898

  Fly   580 PSEALKHPWLRRRL 593
            .::||.||:::.::
  Fly   899 LNQALVHPFIQEKM 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	107/392 (27%)
Dyrk3	NP_001033810.1	S_TKc	276..589	CDD:214567	99/327 (30%)
CG7028	NP_001286884.1	STKc_PRP4	591..908	CDD:271037	100/328 (30%)
CG7028	NP_001286884.1	S_TKc	599..908	CDD:214567	98/320 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810