DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk3 and Hipk2

DIOPT Version :9

Sequence 1:	NP_001033810.1	Gene:	Dyrk3 / 3885567	FlyBaseID:	FBgn0027101	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001102092.1	Gene:	Hipk2 / 362342	RGDID:	1309349	Length:	1195	Species:	Rattus norvegicus

Alignment Length:	705	Identity:	191/705 - (27%)
Similarity:	304/705 - (43%)	Gaps:	151/705 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 NDSKEDFPTQPSNNIANYPGDIQILPIFDCCEISESIQAISLPNVTSP-SKTKDVPGLFLRTISE 157
            :.||...|:||::...:                    .::.:||.:.| .:|...||.....:..
  Rat    52 SQSKNIPPSQPASTTVS--------------------TSLPIPNPSLPYEQTIIFPGSTGHIVVT 96

  Fly   158 NSKSKSEPECESLISVKESSVMENHTFLFHEQI-IMSGQQKCELHEKPK-------VLVVSPQQV 214
            ::.|         .||....:...|..:....: ::...|||.|..|.:       |.::.....
  Rat    97 SASS---------TSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPP 152

  Fly   215 MILYMNKLTPYERTEILTYPQIYFIGANAKKRPGVYGPNNSEYDNEQGAYIHVPHD---HVAYRY 276
            ||  .|..:                ||...........:.:...|.:|.|..|.|:   .:...|
  Rat   153 MI--QNNAS----------------GATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTY 199

  Fly   277 EMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRH--DKYNTMNII 339
            |:|:.:|:|:||||:|.:...|:|.||:||::|...:.||.|.|:.||..|...  |.|   |.:
  Rat   200 EVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDY---NFV 261

  Fly   340 HMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMK 404
            ..::.|..:||||:.||:|..|||:.:|:|.|....|:.:|.....:...|..|....:||.|:|
  Rat   262 RAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLK 326

  Fly   405 PENVLLKQQGRS--GIKVIDFGSSCFENQRI-YTYIQSRFYRAPEVILGGKYGRAIDMWSLGCIL 466
            |||::|....|.  .:|||||||:...::.: .||:|||:|||||:|||..:..|||||||||::
  Rat   327 PENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVI 391

  Fly   467 AELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFF-----SPKGYPRYCTVRTMSD 526
            |||..|..|:||.:|.||:..|.:..|:|.:.:|::..::..||     ||  ||.: .::|..|
  Rat   392 AELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSP--YPLW-RLKTPDD 453

  Fly   527 GMVVLIGGQSRRGKQRGPPCSKSLSKALDGCKDPL-----------------------FLNFIRG 568
                   .::..|.:     ||...|.:..|.|.:                       |::.::.
  Rat   454 -------HEAETGIK-----SKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKK 506

  Fly   569 CLEWDADKRLTPSEALKHPW--LRRRLPRPPSSS-SGCGGVSGLCSSR-------NES------- 616
            .|..|||||:||.|.|.||:  :...|..|.|:. ..|.....:|..|       |:|
  Rat   507 MLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITH 571

  Fly   617 --PVTGQNRNFAAE---TTASSTSATSISLTIKRENSHSSLRLHHGAVPETDFKLIKSVPEGS-- 674
              |.|..|......   ||..:.:.||.|.|:...|...|:..:...:.:.....:.:|.:.|
  Rat   572 VAPSTSTNLTMTFNNQLTTVHNQAPTSTSATLSLANPEVSILNYQSTLYQPSAASMAAVAQRSMP 636

  Fly   675 -STATKEPMMNSDILPESFRQTTVV----------SPSKHSADSGGMSCLSAVDV 718
             .|.|.:....    |:.|:|..:|          |||||:..|..|.  :||.:
  Rat   637 LQTGTAQICAR----PDPFQQALIVCPPGFQGLQASPSKHAGYSVRME--NAVPI 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	134/415 (32%)
Dyrk3	NP_001033810.1	S_TKc	276..589	CDD:214567	124/347 (36%)
Hipk2	NP_001102092.1	STKc_HIPK2	183..537	CDD:271129	128/371 (35%)
Hipk2	NP_001102092.1	S_TKc	199..527	CDD:214567	124/345 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810