DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk3 and lkh1

DIOPT Version :9

Sequence 1:	NP_001033810.1	Gene:	Dyrk3 / 3885567	FlyBaseID:	FBgn0027101	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001018187.2	Gene:	lkh1 / 3361532	PomBaseID:	SPAC1D4.11c	Length:	690	Species:	Schizosaccharomyces pombe

Alignment Length:	635	Identity:	155/635 - (24%)
Similarity:	260/635 - (40%)	Gaps:	170/635 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 LSPPTSLPQI-----QIQMINQNLTHTGIAQ----NNTEKANRHQYRDSGLQYLTRCFEPLAMLN 94
            |.|| .:||:     .:.:.:.||.|..|::    .|..|...|.                   |
pombe   153 LRPP-PVPQVPSHWYPVSLPSPNLPHQPISKPPVIPNLPKLQVHP-------------------N 197

  Fly    95 DSKEDFPTQPSNNIANYPGDIQILPIFDCCEISESIQAISLPNVTSPSKTKDV-PGLFLRTISEN 158
            .........|.::..:||..:        |           |....||....: |...:...|::
pombe   198 RLPHPIHNHPYSSPTSYPPPL--------C-----------PATYCPSNPPQLAPATAIAPSSQS 243

  Fly   159 SKSKSEPECESLISVKESSVMENHTFLFHEQIIMSGQQKCELHEKPKVLVVSPQQVMILYMNKLT 223
            |:.||..     .||..||: .|||                      .:.:||...:.|.|.:.|
pombe   244 SQHKSVN-----YSVTPSSI-NNHT----------------------AVPLSPTLAVWLPMTQPT 280

  Fly   224 ---------------------------------------PYERTEILTYPQIYFIGANAKKRPGV 249
                                                   ||::.:.:..|.::...|
pombe   281 FQPPSANVYQPASNANQVITPVSISDYRPPKKRKRAAWPPYKKVDRVNVPVVHDTTA-------- 337

  Fly   250 YGPNNSEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFH 314
            :.|  |.:|::.|.|..||:...|.||.:::::|.|:||:||:.||..|..|.|:|:.|...::.
pombe   338 FDP--STFDDDDGHYKVVPNSKFANRYTVVRLLGHGTFGKVIQCYDQSTGRHCAIKVTRAIPKYR 400

  Fly   315 RQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLV 379
            ..:..|:|:|..:...|..|....|.:.|||.:|.|.||..:|...::::.:|.|.:..|.|:.:
pombe   401 EASLIELRVLQTIAHSDPTNENKCIQLRDYFDYRKHICIVTDLFGWSVFDFLKNNNYIPFPLKHI 465

  Fly   380 RKFAHSLLQCLDALYKNDIIHCDMKPENVLL-----------------KQQGRSGIKVIDFGSSC 427
            :..:..|.:.:..|:...::|.|:|||||||                 |......|::|||||:.
pombe   466 QMLSQQLFKSVAFLHSLGLVHTDLKPENVLLVSNASRTIRLPYRNYSQKVLNSCEIRLIDFGSAT 530

  Fly   428 FENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVL 492
            ||::...:.:.:|.|||||:|||..:....|:||:||||.||.:|.|||....:|:.|..:.::|
pombe   531 FEDEYHSSVVSTRHYRAPEIILGLGWSYPCDVWSIGCILVELFTGQALFQTHEDSEHLCMMEKIL 595

  Fly   493 GMPNKNILA-SSKRSKSFFSPKGYPRYCTVRTMSDGMVVLIGGQSRRGKQRGPPCSKSLSK---- 552
            |..::|::: ||:.|:.||...|..||....|....:..|                :||..
pombe   596 GPFDRNMISRSSRTSQRFFKSDGKVRYPLSNTPKKSINYL----------------QSLQTLEQI 644

  Fly   553 -ALDGCKDPLFLNFIRGCLEWDADKRLTPSEALKHPWLRRRLPRPPSSSS 601
             |:...:..|.|:.::....:|..:|:|..|||.||:..:     |.||:
pombe   645 FAVSSPEVALLLDLLKKVFVYDPKRRITAKEALWHPFFTQ-----PISSN 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	119/439 (27%)
Dyrk3	NP_001033810.1	S_TKc	276..589	CDD:214567	102/335 (30%)
lkh1	NP_001018187.2	E_Pc_C	<104..198	CDD:284226	12/64 (19%)
		PKc_CLK	349..682	CDD:271036	107/348 (31%)
		S_TKc	362..682	CDD:214567	102/335 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810