Protein Alignment Dyrk3 and dyrk1ab

DIOPT Version :9

• Sequence 1: NP_001033810.1
• Gene: Dyrk3 / 3885567
• FlyBaseID: FBgn0027101
• Length: 828
• Species: Drosophila melanogaster
• Sequence 2: NP_001334760.1
• Gene: dyrk1ab / 327466
• ZFINID: ZDB-GENE-030131-5677
• Length: 719
• Species: Danio rerio
• Alignment Length: 730
• Identity: 218/730 - (29%)
• Similarity: 331/730 - (45%)
• Gaps: 183/730 - (25%)

  Fly   193 SGQQKCELHEKPKVLVVSPQQVMILYMNKLTPY-ERTEILTYPQ--------------------- 235
            |.||..:.|::.     :.|.|.:|      || ::|:.||..|
Zfish     8 SHQQYSDCHQQS-----TDQSVTVL------PYSDQTQALTASQRHMPQCFRDPTLAPLRKLSID 61

  Fly   236 ----------IYFIGANAKKRPGVYGPN------------NSEYDNEQGAYIHVPHDHVAYRYEM 278
                      :|:.   .|||....|..            |..||:|...|:....:....|||:
Zfish    62 LIKTYKHINEVYYA---KKKRRHQQGQGEDSSHKKERKVFNDGYDDENYDYVVKNGEKWMDRYEI 123

  Fly   279 LKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFD 343
            ..:|||||||||:||||....|.||:||::|:|.|..|||.|:|:|..:.:||......|:|:..
Zfish   124 DSLIGKGSFGQVVKAYDRAEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKR 188

  Fly   344 YFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAHSLLQCLDALY----KNDIIHCDMK 404
            :|.||||.|:.||:||.|||:|::...|:|.||.|.||||..|  |...|:    :..|||||:|
Zfish   189 HFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQL--CTALLFLATPELSIIHCDLK 251

  Fly   405 PENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAEL 469
            |||:||....||.||::||||||...||||.||||||||:|||:||..|..|||||||||||.|:
Zfish   252 PENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEM 316

  Fly   470 LSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFFSPKGYPRYCTVRTMSDGMVVLIGG 534
            .:|..||.|.||.||:..|:||||:|..:|:..:.:::.||           ..:|||...:  .
Zfish   317 HTGEPLFSGANEVDQMNKIVEVLGIPPNHIMDLAPKARKFF-----------EKLSDGTWSI--K 368

  Fly   535 QSRRGKQRGPPCSKSLSKALD-GCKDP----------------LFLNFIRGCLEWDADKRLTPSE 582
            :::.||:..||.|:.|...|. .|..|                .|.:.|...|::|...|:.|..
Zfish   369 KTKDGKRYKPPASRKLHAILGVECGGPGGRRAGESGHAVADYLKFKDLILRMLDYDPKTRIQPYY 433

  Fly   583 ALKHPWLRRRLPRPPSSSSGCGGVSGLCSSRNESPVTGQNRNFAAETTASS----TSATSISLTI 643
            ||:|.:.::......::|          ||.:.||...|:::....::.||    :|.||.|...
Zfish   434 ALQHSFFKKTTDEGTNTS----------SSVSTSPALEQSQSSGTTSSTSSSSGGSSGTSTSGRA 488

  Fly   644 KRENSHSSLRLHH--------GAVPETDFKLIKSVPEGSSTATKEPMMNSDILP----------- 689
            :.:.:|     ||        .|:|..|.       :......::|.....:.|
Zfish   489 RSDPTH-----HHRHSSGHFGTAMPAIDC-------DNLCPQARQPYHPPVVWPGIVGPEPVTVE 541

  Fly   690 -ESFRQTTVVSPSKHSADSGGMSCLSAVDVGPSRYYPYMNNNENN--------------RLFSSS 739
             ...::||...|.:|                |...:|:.:::.::              ||::|.
Zfish   542 THPVQETTFHVPPQH----------------PKALHPHHHHHHHHHHHHGQVIATRPRPRLYNSP 590

  Fly   740 LNSSANSLS------HLEQATKLDALGEYSASTTPNLLSKNTGYSFNSGSINIDVAQESLVNIAS 798
            .||::...|      ||.. |.|.     |::::.:..|.:||...|. :..:.....:.::.:.
Zfish   591 TNSASTQDSMEVVHGHLSM-TSLS-----SSASSSSTSSSSTGNHGNQ-AYQLRHLPANTLDFSQ 648

  Fly   799 NYALDKSIDIIGKSN 813
            |.:|..|:.:...||
Zfish   649 NGSLSMSMGLGAFSN 663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	168/442 (38%)
		S_TKc	276..589	CDD:214567	148/333 (44%)
dyrk1ab	NP_001334760.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840