DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk3 and Dyrk3

DIOPT Version :9

Sequence 1:	NP_001033810.1	Gene:	Dyrk3 / 3885567	FlyBaseID:	FBgn0027101	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001019938.1	Gene:	Dyrk3 / 304775	RGDID:	1310924	Length:	586	Species:	Rattus norvegicus

Alignment Length:	460	Identity:	279/460 - (60%)
Similarity:	346/460 - (75%)	Gaps:	16/460 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 GQQKCELHEKP-KVLVVSPQQVMILYMNKLTPYERTEILTYPQIYFIGANAKKRPGVY-GPNNSE 256
            |..||.|..:| |||.::|:|.:..|.:.||.||:.||::||:|||:|.|||||.||. ||||..
  Rat   124 GTVKCSLSSRPSKVLPLTPEQALKQYKHHLTAYEKLEIISYPEIYFVGPNAKKRQGVIGGPNNGG 188

  Fly   257 YDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEI 321
            ||:..|||||||.||:|||||:||||||||||||.:.||||..::||||:|||||||||||.|||
  Rat   189 YDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEI 253

  Fly   322 RILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAHSL 386
            |||.||::.||..:||:|||.:.||||||.|:.||||||:||||||||.|:|||:|||||||.|:
  Rat   254 RILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSI 318

  Fly   387 LQCLDALYKNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGG 451
            ||.||||:||.|||||:||||:|||..|||..|||||||||||.|::|||||||||||||:|||.
  Rat   319 LQSLDALHKNKIIHCDLKPENILLKHHGRSATKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGC 383

  Fly   452 KYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFFSPKGYP 516
            :|...||:||.||||||||:|..|||||:|.|||||::|:||||.:.:|..|||:|.|.:.||.|
  Rat   384 RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPQKLLEQSKRAKYFINSKGLP 448

  Fly   517 RYCTVRTMSDGMVVLIGGQSRRGKQRGPPCSKSLSKALDGCKDPLFLNFIRGCLEWDADKRLTPS 581
            |||:|.|.:||.|||:||:|||||:||||.||..:.||.||.|.||:.|::.||:||...||||:
  Rat   449 RYCSVTTQTDGRVVLLGGRSRRGKKRGPPGSKDWAAALKGCDDYLFIEFLKRCLQWDPSARLTPA 513

  Fly   582 EALKHPWLRRRLPRPPSSSSGCG--------GVSGLCSSRNESPVTGQNRNFAAETTASSTSATS 638
            :||:|||:.:..|||.::....|        ...||.|..  .||.|    .|::..|:..|.||
  Rat   514 QALRHPWISKSAPRPLTTDKVSGKRVVNPTNAFQGLGSKL--PPVVG----IASKLKANLMSETS 572

  Fly   639 ISLTI 643
            .|:.:
  Rat   573 GSIPL 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	254/378 (67%)
Dyrk3	NP_001033810.1	S_TKc	276..589	CDD:214567	214/312 (69%)
Dyrk3	NP_001019938.1	Disordered. /evidence=ECO:0000250\|UniProtKB:O43781	1..187		34/64 (53%)
		PKc_DYRK2_3	142..521	CDD:271126	254/379 (67%)
		S_TKc	208..521	CDD:214567	213/312 (68%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:O43781	467..480		10/12 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	507	1.000	Domainoid score	I315
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162948at33208
OrthoFinder	1	1.000	-	-		FOG0000895
OrthoInspector	1	1.000	-	-		otm45681
orthoMCL	1	0.900	-	-		OOG6_100394
Panther	1	1.100	-	-	O	PTHR24058
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X888
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.920