DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk3 and Prpf4b

DIOPT Version :9

Sequence 1:	NP_001033810.1	Gene:	Dyrk3 / 3885567	FlyBaseID:	FBgn0027101	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001011923.1	Gene:	Prpf4b / 291078	RGDID:	1307784	Length:	1007	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	143/546 - (26%)
Similarity:	238/546 - (43%)	Gaps:	117/546 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 QYLTRCFEPLAMLNDSKEDFPTQPSNNIANYPGDIQILPIFDCCEISESIQAISLPNVTSPSKTK 145
            |.:.:.::.||  .||....|::||:                             |..::.|::.
  Rat   546 QAIVQKYKYLA--EDSNISVPSEPSS-----------------------------PQSSTRSRSP 579

  Fly   146 DVPGLFLRTISENSKSKSEPECESLISVKESSVMENHTFLFHEQIIMSGQQKCELHEKPKVLVVS 210
            . |...|..::.:.|   |.|.|: :...|:||...|..:..||...|.|:|.
  Rat   580 S-PDDILERVAADVK---EYEREN-VDTFEASVKAKHNLMTVEQNNGSSQKKL------------ 627

  Fly   211 PQQVMILYMNKLTPYERTEILTYPQIYF---------IGANAKKRPGVYGPNNSEYDNEQGAYIH 266
                       |.|...||.......||         ||.:.|:.|.:    ...:.:.:|.|..
  Rat   628 -----------LAPDMFTESDDMFAAYFDSARLRAAGIGKDFKENPNL----RDNWTDAEGYYRV 677

  Fly   267 VPHDHVAYRYEMLKIIGKGSFGQVIKAYDH-KTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRH 330
            ...:.:..||.:....|:|.|..|::|.|: :.::.||:||:||.:...:...:|:..|..|...
  Rat   678 NIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDA 742

  Fly   331 DKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFK-GFSLQLVRKFAHSLLQCLDALY 394
            |..:..:.:.:|.:|..:.|.|:.||.||:||.|::||.|.. |..::.||.::..|...|..|.
  Rat   743 DPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLK 807

  Fly   395 KNDIIHCDMKPENVLLKQQGRSGIKVIDFGS-SCFENQRIYTYIQSRFYRAPEVILGGKYGRAID 458
            :.:|:|.|:||:|:|: .:.::.:|:.|||| |...:..|..|:.||||||||:|:|..|...||
  Rat   808 RCNILHADIKPDNILV-NESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGID 871

  Fly   459 MWSLGCILAELLSGHALFPGENESDQLACIIEVLG-MPNKNILASSKRSKSFFSPKGYPR----- 517
            |||:||.|.||.:|..||||:..:..|...:::.| ||||.|      .|..|..:.:.:
  Rat   872 MWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMI------RKGVFKDQHFDQNLNFM 930

  Fly   518 ---------------YCTVRTMSDGMVVLIGGQSRRGKQRGPPCSKSLSKALDGCKDPLFLNFIR 567
                           ..|:....|.:..|||.|.....||         |.:...||     .:.
  Rat   931 YIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQR---------KKVHQLKD-----LLD 981

  Fly   568 GCLEWDADKRLTPSEALKHPWLRRRL 593
            ..|..|..||::.::||:|.:::.::
  Rat   982 QILMLDPAKRISINQALQHAFIQEKI 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	118/410 (29%)
Dyrk3	NP_001033810.1	S_TKc	276..589	CDD:214567	105/336 (31%)
Prpf4b	NP_001011923.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..104
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	141..535
		PTZ00108	<171..396	CDD:240271
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	560..583		6/52 (12%)
		STKc_PRP4	686..1003	CDD:271037	106/337 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810