DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk3 and HIPK2

DIOPT Version :9

Sequence 1:	NP_001033810.1	Gene:	Dyrk3 / 3885567	FlyBaseID:	FBgn0027101	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_011514379.1	Gene:	HIPK2 / 28996	HGNCID:	14402	Length:	1377	Species:	Homo sapiens

Alignment Length:	841	Identity:	220/841 - (26%)
Similarity:	348/841 - (41%)	Gaps:	208/841 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 GLQYLT---RCFEPLAMLNDSKEDFPTQPSNNIANYPGDIQILPIFDCCEISESIQAISLPNV-- 138
            |||..|   :| :.|..||..      .|.:.....||....:.:|.    ..::|:.:..:|
Human   156 GLQEATLENKC-QVLKRLNIE------SPPDLAVPLPGMASHVQVFS----PHTLQSSAFCSVKK 209

  Fly   139 --TSPSKTKDVPGLFLRTISENSKSKSEPECESLISVKESSVMENHTFLFHEQII---------- 191
              ..||...|:.|....: ...|:||:.|..:...:...:|:...:..|.:||.|
Human   210 LKIEPSSNWDMTGYGSHS-KVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIV 273

  Fly   192 --------MSGQ--------------------QKCELHEKPK-------VLVVSPQQVMILYMNK 221
                    ::||                    |||.|..|.:       |.::.....||  .|.
Human   274 VTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMI--QNN 336

  Fly   222 LTPYERTEILTYPQIYFIGANAKKRPGVYGPNNSEYDNEQGAYIHVPHD---HVAYRYEMLKIIG 283
            .:                ||...........:.:...|.:|.|..|.|:   .:...||:|:.:|
Human   337 AS----------------GATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLG 385

  Fly   284 KGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRH--DKYNTMNIIHMFDYFT 346
            :|:||||:|.:...|:|.||:||::|...:.||.|.|:.||..|...  |.|   |.:..::.|.
Human   386 RGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDY---NFVRAYECFQ 447

  Fly   347 FRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLK 411
            .:||||:.||:|..|||:.:|:|.|....|:.:|.....:...|..|....:||.|:||||::|.
Human   448 HKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLV 512

  Fly   412 QQGRS--GIKVIDFGSSCFENQRI-YTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGH 473
            ...|.  .:|||||||:...::.: .||:|||:|||||:|||..:..|||||||||::|||..|.
Human   513 DPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGW 577

  Fly   474 ALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFF-----SPKGYPRYCTVRTMSDGMVVLIG 533
            .|:||.:|.||:..|.:..|:|.:.:|::..::..||     ||  ||.: .::|..|
Human   578 PLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSP--YPLW-RLKTPDD------- 632

  Fly   534 GQSRRGKQRGPPCSKSLSKALDGCKDPL-----------------------FLNFIRGCLEWDAD 575
            .::..|.:     ||...|.:..|.|.:                       |::.::..|..|||
Human   633 HEAETGIK-----SKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDAD 692

  Fly   576 KRLTPSEALKHPW--LRRRLPRPPSSS-SGCGGVSGLCSSR-------NES---------PVTGQ 621
            ||:||.|.|.||:  :...|..|.|:. ..|.....:|..|       |:|         |.|..
Human   693 KRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTST 757

  Fly   622 NRNFAAE---TTASSTSATSISLTIKRENSHSSLRLHHGAVPETDFKLIKSVPEGSSTAT----K 679
            |......   ||..:.:.:|.|.||...|...|: |::   |.|.::     |..:|.|.    .
Human   758 NLTMTFNNQLTTVHNQAPSSTSATISLANPEVSI-LNY---PSTLYQ-----PSAASMAAVAQRS 813

  Fly   680 EPMMNSD----ILPESFRQTTVVSPSKHSADSGGMSCLSAVDVGPSRYYPYMNNNENNRLFSSSL 740
            .|:....    ..|:.|:|..:|.|.       |...|.|   .||::..|....|
Human   814 MPLQTGTAQICARPDPFQQALIVCPP-------GFQGLQA---SPSKHAGYSVRME--------- 859

  Fly   741 NSSANSLSHLEQATKLDALGEYSASTTPNLLSKNTGYSFNSGS--INIDVAQESLVNIASN 799
                |::..:.||.     |.......|.||::.   ::.||:  |.:..|.:.|..:|::
Human   860 ----NAVPIVTQAP-----GAQPLQIQPGLLAQQ---AWPSGTQQILLPPAWQQLTGVATH 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	134/415 (32%)
Dyrk3	NP_001033810.1	S_TKc	276..589	CDD:214567	124/347 (36%)
HIPK2	XP_011514379.1	STKc_HIPK2	362..716	CDD:271129	128/371 (35%)
HIPK2	XP_011514379.1	S_TKc	378..706	CDD:214567	124/345 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840