Protein Alignment Dyrk3 and Hipk4

DIOPT Version :9

• Sequence 1: NP_001033810.1
• Gene: Dyrk3 / 3885567
• FlyBaseID: FBgn0027101
• Length: 828
• Species: Drosophila melanogaster
• Sequence 2: NP_001028487.2
• Gene: Hipk4 / 233020
• MGIID: 2685008
• Length: 616
• Species: Mus musculus
• Alignment Length: 586
• Identity: 155/586 - (26%)
• Similarity: 251/586 - (42%)
• Gaps: 137/586 - (23%)

  Fly   276 YEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIH 340
            |::::::|||:||:|.|.:...|.|.||:||::|:....|..:.|:::|..:|..|. :..::|.
Mouse    11 YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRSRIIKNELKLLRCVRGLDP-DEAHVIR 74

  Fly   341 MFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKP 405
            ..::|.......:.||||..||:|..|:|.|.....:.:|.....:|:.|..|.:..|||.|:||
Mouse    75 FLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLRALARLKELAIIHADLKP 139

  Fly   406 ENVLLKQQGRS--GIKVIDFGSSCFENQRIYT---YIQSRFYRAPEVILGGKYGRAIDMWSLGCI 465
            ||::|..|.|.  .:|||||||:...::..|.   |||||||||||::||..:...:|:|||||:
Mouse   140 ENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWSLGCV 204

  Fly   466 LAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFFSPKGYPRYCTVRTMSDGMVV 530
            :|||..|..|:||.||.||:..|.|..|:|..::|.:::::..||....:|.......:......
Mouse   205 MAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAARKAHHFFKRNPHPDATNPWQLKSSADY 269

  Fly   531 LIGGQSRRGKQRGPPCSKSLSKALD--------GCKDPL----------------FLNFIRGCLE 571
            |...:.|..::|     |.:.|:||        |....|                .:..|:..|.
Mouse   270 LAETKVRPLERR-----KYMLKSLDQIETVNGGGAVSRLSFPDREALAEHADLKSMVELIKRMLT 329

  Fly   572 WDADKRLTPSEALKHPWLRR--------------------RL-------PRPP------------ 597
            |::.:|::||.||:||::..                    ||       |.||
Mouse   330 WESHERISPSAALRHPFVSMQQLRSAHEATRYYQLSLRGCRLSLQVDGKPPPPVIASAEDGPPYY 394

  Fly   598 -----SSSSGCGGVSGLCSSRNESPVTGQNRNFAAETTASSTSATSISLTIKRENSHSSLRLHHG 657
                 ..::|.|||:|..|...|....|..|
Mouse   395 RLAEEEETAGLGGVTGSGSFFREDKAPGMQR---------------------------------- 425

  Fly   658 AVPETDFKLIKSVPEGSSTATKEPMMNSDILPESFRQTTVVSPSKHSADSGGMSCLSAVDVGPSR 722
            |:.:.|...::....|..:.|:..|::..::|     ..|.|.|....|||....|:.
Mouse   426 AIDQLDDLSLQEARRGLWSDTRADMVSDMLVP-----LKVASTSHRVPDSGPEPILAF------- 478

  Fly   723 YYPYMNNNENNRLFSSSLNSSAN--SLSHLEQATKLDA---------LGE-YSASTTPNLLSKNT 775
            |...:......|...:...|.:|  :|..|.||:..||         .|| .:.||.|:::.:..
Mouse   479 YGSRLTGRHKARKAPAGSKSDSNFSNLIRLSQASPEDAGPCRGSGWEEGEGRTTSTEPSVIPQRE 543

  Fly   776 G 776
            |
Mouse   544 G 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	112/341 (33%)
		S_TKc	276..589	CDD:214567	112/341 (33%)
Hipk4	NP_001028487.2	PKc_like	11..347	CDD:304357	112/341 (33%)
		S_TKc	11..347	CDD:214567	112/341 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	487..616		15/58 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845486
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740