DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk3 and Dyrk3

DIOPT Version :9

Sequence 1:	NP_001033810.1	Gene:	Dyrk3 / 3885567	FlyBaseID:	FBgn0027101	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_663483.1	Gene:	Dyrk3 / 226419	MGIID:	1330300	Length:	586	Species:	Mus musculus

Alignment Length:	496	Identity:	284/496 - (57%)
Similarity:	354/496 - (71%)	Gaps:	34/496 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 NSKSKSEPECESLISVKESSVMENHTFLFHEQIIMSGQQKCELHEKP-KVLVVSPQQVMILYMNK 221
            ::..||.|..:...|...|:|                  ||.|..:| |||.::|:|.:..|.:.
Mouse   106 SNSEKSSPASQGKSSESLSAV------------------KCNLSSRPSKVLPLTPEQALKQYKHH 152

  Fly   222 LTPYERTEILTYPQIYFIGANAKKRPGVY-GPNNSEYDNEQGAYIHVPHDHVAYRYEMLKIIGKG 285
            ||.||:.||::||:|||:|.|||||.||. ||||..||:..|||||||.||:|||||:|||||||
Mouse   153 LTAYEKLEIVSYPEIYFVGPNAKKRQGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKG 217

  Fly   286 SFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNH 350
            |||||.:.||||..::||||:|||||||||||.||||||.||::.||..:||:|||.:.||||||
Mouse   218 SFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNH 282

  Fly   351 TCITFELLSINLYELIKKNGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGR 415
            .|:.||||||:||||||||.|:|||:|||||||.|:||.||||:||.|||||:||||:|||..||
Mouse   283 VCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGR 347

  Fly   416 SGIKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGEN 480
            |..|||||||||||.|::|||||||||||||:|||.:|...||:||.||||||||:|..|||||:
Mouse   348 SATKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILAELLTGQPLFPGED 412

  Fly   481 ESDQLACIIEVLGMPNKNILASSKRSKSFFSPKGYPRYCTVRTMSDGMVVLIGGQSRRGKQRGPP 545
            |.|||||:||:||||.:.:|..|||:|.|.:.||.||||:|.|.:||.|||:||:|||||:||||
Mouse   413 EGDQLACMIELLGMPPQKLLEQSKRAKYFINSKGLPRYCSVSTQTDGRVVLLGGRSRRGKKRGPP 477

  Fly   546 CSKSLSKALDGCKDPLFLNFIRGCLEWDADKRLTPSEALKHPWLRRRLPRPPSSSSGCG------ 604
            .||..:.||.||.|.||:.|::.||:||...||||::||:|||:.:..|:|.:.....|
Mouse   478 GSKDWATALKGCGDYLFIEFLKRCLQWDPSARLTPAQALRHPWISKSTPKPLTMDKVPGKRVVNP 542

  Fly   605 --GVSGLCSSRNESPVTGQNRNFAAETTASSTSATSISLTI 643
              ...||.|..  .||.|    .|::..|:..|.||.|:.:
Mouse   543 TNAFQGLGSKL--PPVVG----IASKLKANLMSETSGSIPL 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	255/378 (67%)
Dyrk3	NP_001033810.1	S_TKc	276..589	CDD:214567	215/312 (69%)
Dyrk3	NP_663483.1	Disordered. /evidence=ECO:0000250\|UniProtKB:O43781	1..187		26/81 (32%)
		PKc_DYRK2_3	142..521	CDD:271126	252/380 (66%)
		S_TKc	208..521	CDD:214567	217/312 (70%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:O43781	467..480		7/12 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	507	1.000	Domainoid score	I332
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000895
OrthoInspector	1	1.000	-	-		otm43608
orthoMCL	1	0.900	-	-		OOG6_100394
Panther	1	1.100	-	-	O	PTHR24058
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	1	1.000	-	-		X888
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.800