DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk3 and HIPK1

DIOPT Version :9

Sequence 1:	NP_001033810.1	Gene:	Dyrk3 / 3885567	FlyBaseID:	FBgn0027101	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001356735.1	Gene:	HIPK1 / 204851	HGNCID:	19006	Length:	1210	Species:	Homo sapiens

Alignment Length:	685	Identity:	194/685 - (28%)
Similarity:	313/685 - (45%)	Gaps:	128/685 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 SNNIANYPGDIQILPIFDCCEISESIQAISLPNVTSPSKTKDVPGL--FLRTISENSKSKSEPEC 167
            |:.:||:.     :|.:|        |.:.||          .|.:  .:.|.:::|.|.:
Human    59 SHQVANFN-----IPAYD--------QGLLLP----------APAVEHIVVTAADSSGSAA---- 96

  Fly   168 ESLISVKESSVMENHTFLFHEQ--IIMSGQQKCELHEKPKVLVVSPQQVMILYMNKLTPYERTEI 230
                    :|..::...|.|..  .::...|||.|..|.:. |.|...|.|:        |....
Human    97 --------TSTFQSSQTLTHRSNVSLLEPYQKCGLKRKSEE-VDSNGSVQII--------EEHPP 144

  Fly   231 LTYPQIYFIGANAKKRPGVYGPNNSEYDNEQGAYIHVPHD---HVAYRYEMLKIIGKGSFGQVIK 292
            |.......:||.|......   ..|...:.:|.|..|.|:   .:...||:|:.:|:|:||||.|
Human   145 LMLQNRTVVGAAATTTTVT---TKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAK 206

  Fly   293 AYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHL--RRHDKYNTMNIIHMFDYFTFRNHTCITF 355
            .:...|.|.||:||::|...:.||.|.|:.||..|  ...|:|   |.:..::.|..:||||:.|
Human   207 CWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEY---NFVRSYECFQHKNHTCLVF 268

  Fly   356 ELLSINLYELIKKNGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRS--GI 418
            |:|..|||:.:|:|.|....|:.:|.....:...|..|....:||.|:||||::|....|.  .:
Human   269 EMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRV 333

  Fly   419 KVIDFGSSCFENQRI-YTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENES 482
            |||||||:...::.: .||:|||:|||||:|||..:..|||||||||::|||..|..|:||.:|.
Human   334 KVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEY 398

  Fly   483 DQLACIIEVLGMPNKNILASSKRSKSFFS--PK-GYPRYCTVRTMSDGMVVLIGGQSRRGKQRGP 544
            ||:..|.:..|:|.:.:|::..::..||:  |. |||.: .::|..:..:. .|.:|:..::...
Human   399 DQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLW-RLKTPEEHELE-TGIKSKEARKYIF 461

  Fly   545 PC-----SKSLSKALDGCKDPL--------FLNFIRGCLEWDADKRLTPSEALKHPW--LRRRLP 594
            .|     ..::|..|:| .|.|        :::.::..|..|||||:||.:.|.|.:  :...|.
Human   462 NCLDDMAQVNMSTDLEG-TDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLD 525

  Fly   595 RPPSSS-SGCGGVSGLCSSR----------------NESPVTGQN------------RNFAAETT 630
            .|.|:. ..|.....:|..|                :.:|.|..|            .|.|:...
Human   526 FPHSNHVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLA 590

  Fly   631 ASSTSATSISLTIKRENSHSSLRLHHGA--------VPETDFKLIKSVPEGSSTATK-EPMMNSD 686
            :|||:|.:   |:...||..||..:..|        ||....:.:...|..:...|: :|...:.
Human   591 SSSTAAAA---TLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTF 652

  Fly   687 IL-PESFRQTTVVSPSKHSADSGGMSCLSAVDVGP 720
            |: |.:| ||.:.:.:|||.....|.  :||.:.|
Human   653 IVCPPAF-QTGLQATTKHSGFPVRMD--NAVPIVP 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	134/403 (33%)
Dyrk3	NP_001033810.1	S_TKc	276..589	CDD:214567	122/335 (36%)
HIPK1	NP_001356735.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1084..1103
		STKc_HIPK1	174..528	CDD:271130	126/359 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	835..856
		Nuclear localization signal 1 (NLS1). /evidence=ECO:0000250	844..847
		Interaction with TP53. /evidence=ECO:0000269\|PubMed:12702766	885..1093
		Required for localization to nuclear speckles. /evidence=ECO:0000250	891..998
		SUMO interaction motifs (SIM), required for nuclear localization and kinase activity. /evidence=ECO:0000250	902..926
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	909..974
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1046..1069
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840