DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk3 and DYRK1A

DIOPT Version :9

Sequence 1:	NP_001033810.1	Gene:	Dyrk3 / 3885567	FlyBaseID:	FBgn0027101	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001387.2	Gene:	DYRK1A / 1859	HGNCID:	3091	Length:	763	Species:	Homo sapiens

Alignment Length:	731	Identity:	228/731 - (31%)
Similarity:	341/731 - (46%)	Gaps:	133/731 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 KESSVMENHTFLFH-------------------EQIIMSGQQKCELHEKPKVLVVSPQQVM--IL 217
            |.|||....:|.||                   .|..:|.||...|....::......|||  |:
Human    11 KPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSDQIQQPLTNQVMPDIV 75

  Fly   218 YMNKLTPYERTEILTYP----------------QIYFI------------GANAKKRPGVYGPNN 254
            .:.:..|....:..|.|                ::|:.            .::.||...||   |
Human    76 MLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVY---N 137

  Fly   255 SEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQE 319
            ..||::...||....:....|||:..:|||||||||:||||....|.||:||::|:|.|..|||.
Human   138 DGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQI 202

  Fly   320 EIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAH 384
            |:|:|..:.:||......|:|:..:|.||||.|:.||:||.|||:|::...|:|.||.|.||||.
Human   203 EVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQ 267

  Fly   385 SLLQCLDALY----KNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRAP 445
            .:  |...|:    :..|||||:||||:||....||.||::||||||...||||.||||||||:|
Human   268 QM--CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSP 330

  Fly   446 EVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFF 510
            ||:||..|..|||||||||||.|:.:|..||.|.||.||:..|:||||:|..:||..:.:::.||
Human   331 EVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395

  Fly   511 S--PKGYPRYCTVRTMSDGMVVLIGGQSRR-----GKQRGPPCSKSLSKALDGCKDPL-FLNFIR 567
            .  |.|   ...::...||........:|:     |.:.|.|..:...::.....|.| |.:.|.
Human   396 EKLPDG---TWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLIL 457

  Fly   568 GCLEWDADKRLTPSEALKHPWLRRRLPRPPSSSSGCGGVSGLCSSRNESPVTGQNRNFAAETTAS 632
            ..|::|...|:.|..||:|.:.::......::|          :|.:.||...|:::....::.|
Human   458 RMLDYDPKTRIQPYYALQHSFFKKTADEGTNTS----------NSVSTSPAMEQSQSSGTTSSTS 512

  Fly   633 S----TSATSISLTIKRENSHSSLRLHHG-----AVP----ETDFKLIKS---VPEGSSTATKEP 681
            |    :|.||.|...:.:.:|.  ..|.|     ||.    ||....::.   .|.|.|......
Human   513 SSSGGSSGTSNSGRARSDPTHQ--HRHSGGHFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPT 575

  Fly   682 MMNSDILPESFRQTTV-VSPSK-----HSADSGGMSCLSAVDVGPSRYYPY------------MN 728
            .:..:..|  .::||. |:|.:     |..:|             |.::.:            :.
Human   576 QVTVETHP--VQETTFHVAPQQNALHHHHGNS-------------SHHHHHHHHHHHHHGQQALG 625

  Fly   729 NNENNRLFSSSLNSSANSLSHLEQATKLDALGEYSASTT-PNLLSKNTGYSFNSGSINIDVAQES 792
            |....|:::|..|||:...| :|......::...|:||| .:..|.:||...|....|..||..:
Human   626 NRTRPRVYNSPTNSSSTQDS-MEVGHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQNRPVAANT 689

  Fly   793 LVNIASNYALDKSIDI 808
            | :...|.|:|.::.:
Human   690 L-DFGQNGAMDVNLTV 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	164/419 (39%)
Dyrk3	NP_001033810.1	S_TKc	276..589	CDD:214567	146/324 (45%)
DYRK1A	NP_001387.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..57		4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	115..136		2/20 (10%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	117..134		2/16 (13%)
		PKc_DYRK1	148..484	CDD:271128	148/340 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..442		6/33 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	485..540		13/66 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	596..679		19/96 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	744..763
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840