Protein Alignment Dyrk3 and DYRK1A

DIOPT Version :10

• Sequence 1: NP_001033810.1
• Gene: Dyrk3 / 3885567
• FlyBaseID: FBgn0027101
• Length: 828
• Species: Drosophila melanogaster
• Sequence 2: NP_001387.2
• Gene: DYRK1A / 1859
• HGNCID: 3091
• Length: 763
• Species: Homo sapiens
• Alignment Length: 731
• Identity: 228/731 - (31%)
• Similarity: 341/731 - (46%)
• Gaps: 133/731 - (18%)

  Fly   174 KESSVMENHTFLFH-------------------EQIIMSGQQKCELHEKPKVLVVSPQQVM--IL 217
            |.|||....:|.||                   .|..:|.||...|....::......|||  |:
Human    11 KPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSDQIQQPLTNQVMPDIV 75

  Fly   218 YMNKLTPYERTEILTYP----------------QIYFI------------GANAKKRPGVYGPNN 254
            .:.:..|....:..|.|                ::|:.            .::.||...||   |
Human    76 MLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVY---N 137

  Fly   255 SEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQE 319
            ..||::...||....:....|||:..:|||||||||:||||....|.||:||::|:|.|..|||.
Human   138 DGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQI 202

  Fly   320 EIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAH 384
            |:|:|..:.:||......|:|:..:|.||||.|:.||:||.|||:|::...|:|.||.|.||||.
Human   203 EVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQ 267

  Fly   385 SLLQCLDALY----KNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRAP 445
            .:  |...|:    :..|||||:||||:||....||.||::||||||...||||.||||||||:|
Human   268 QM--CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSP 330

  Fly   446 EVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFF 510
            ||:||..|..|||||||||||.|:.:|..||.|.||.||:..|:||||:|..:||..:.:::.||
Human   331 EVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395

  Fly   511 S--PKGYPRYCTVRTMSDGMVVLIGGQSRR-----GKQRGPPCSKSLSKALDGCKDPL-FLNFIR 567
            .  |.|   ...::...||........:|:     |.:.|.|..:...::.....|.| |.:.|.
Human   396 EKLPDG---TWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLIL 457

  Fly   568 GCLEWDADKRLTPSEALKHPWLRRRLPRPPSSSSGCGGVSGLCSSRNESPVTGQNRNFAAETTAS 632
            ..|::|...|:.|..||:|.:.::......::|          :|.:.||...|:::....::.|
Human   458 RMLDYDPKTRIQPYYALQHSFFKKTADEGTNTS----------NSVSTSPAMEQSQSSGTTSSTS 512

  Fly   633 S----TSATSISLTIKRENSHSSLRLHHG-----AVP----ETDFKLIKS---VPEGSSTATKEP 681
            |    :|.||.|...:.:.:|.  ..|.|     ||.    ||....::.   .|.|.|......
Human   513 SSSGGSSGTSNSGRARSDPTHQ--HRHSGGHFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPT 575

  Fly   682 MMNSDILPESFRQTTV-VSPSK-----HSADSGGMSCLSAVDVGPSRYYPY------------MN 728
            .:..:..|  .::||. |:|.:     |..:|             |.::.:            :.
Human   576 QVTVETHP--VQETTFHVAPQQNALHHHHGNS-------------SHHHHHHHHHHHHHGQQALG 625

  Fly   729 NNENNRLFSSSLNSSANSLSHLEQATKLDALGEYSASTT-PNLLSKNTGYSFNSGSINIDVAQES 792
            |....|:::|..|||:...| :|......::...|:||| .:..|.:||...|....|..||..:
Human   626 NRTRPRVYNSPTNSSSTQDS-MEVGHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQNRPVAANT 689

  Fly   793 LVNIASNYALDKSIDI 808
            | :...|.|:|.::.:
Human   690 L-DFGQNGAMDVNLTV 704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	164/419 (39%)
DYRK1A	NP_001387.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	32..57		4/24 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..136		2/20 (10%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	117..134		2/16 (13%)
		PKc_DYRK1	148..484	CDD:271128	148/340 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	408..442		6/33 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	485..540		13/66 (20%)
		Histidine-rich domain (HRD). /evidence=ECO:0000269|PubMed:29849146	595..625		3/42 (7%)
		Disordered. /evidence=ECO:0000269|PubMed:29849146	596..679		19/96 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	744..763