Protein Alignment Dyrk3 and mbk-1

DIOPT Version :9

• Sequence 1: NP_001033810.1
• Gene: Dyrk3 / 3885567
• FlyBaseID: FBgn0027101
• Length: 828
• Species: Drosophila melanogaster
• Sequence 2: NP_510460.2
• Gene: mbk-1 / 181578
• WormBaseID: WBGene00003149
• Length: 882
• Species: Caenorhabditis elegans
• Alignment Length: 828
• Identity: 242/828 - (29%)
• Similarity: 342/828 - (41%)
• Gaps: 153/828 - (18%)

  Fly     4 SQEKKNNHIELSETPATDKNNLNTTH--LENTQLSKALSPPTSLPQIQ--IQMINQNLTHTGIAQ 64
            |......|.:::..|..:.|||..|.  .|:.||....:......|.|  .|.|.|......|||
 Worm    20 SYSNTQQHSQMTNLPPINHNNLCDTEPMNEDFQLQDVQADELQKQQKQQEQQHIQQQNAQRFIAQ 84

  Fly    65 NNTEKANRHQYRD---SGLQYLTRCFEP-------------LAMLNDSKEDFPTQP-------SN 106
            :....:|..::..   :.::..:..|.|             ::|.|......|..|       ..
 Worm    85 SRQPHSNILRFPQPPITSIKTNSHAFYPQQEVTQVRPKKHRVSMTNAEAALTPGMPPEKQAAKKR 149

  Fly   107 NIANY-----PGDIQILPI-FDCCEISESIQAISLPNVTSPSK-TKDV--------PGLFLRTIS 156
            ||..:     |..|.::.| |:.......||....|......| |.|:        ...:||...
 Worm   150 NIGQFSTDTVPAGIGMIGIPFESTSKPLQIQQFRNPQDAPVRKLTSDLIKTYKAINESFYLRKQV 214

  Fly   157 ENSKSKSEPECESLISVKESSVMENHTFLFHEQIIMSG-----QQKCELHEKPKVLV---VSPQQ 213
            ...:.||:...:...|...|......||..|..|.::.     ||  :.|:....|:   ..|..
 Worm   215 RRDRHKSQDAGKPKGSKDGSGASLTDTFSIHNAIPITSSDNHYQQ--DAHQNAPPLLDTNAPPTS 277

  Fly   214 VMILYMNKLTPYERTEILTYPQIYFIGANAKKRPGVYGPNNSEYDNEQGAYIHVPHDHVAYRYEM 278
            .|::.|...|..::.:              :::....||.|:.||::...||....:....||.:
 Worm   278 TMVVPMRTETDLQQQQ--------------RQKSSRGGPYNNGYDDQNYDYILKNGEIFDKRYVI 328

  Fly   279 LK--IIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHM 341
            |.  .:||||||||.||||....|.||:||::|:|.|..|||.||.:|.....|||.|..||:.:
 Worm   329 LSDTPVGKGSFGQVTKAYDTLNKEEVAIKIIKNKKTFFDQAQIEIHLLELTNAHDKDNKYNIVTL 393

  Fly   342 FDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAHSLLQCLDALYKND--IIHCDMK 404
            ..:|..|.|.|:.|||||.|||:|:|...|:|.||.|.||||..|.:.|..|...:  |||||:|
 Worm   394 KGHFVHRAHLCLVFELLSYNLYDLLKNTSFRGVSLNLARKFAQQLGKTLLFLSSPELSIIHCDLK 458

  Fly   405 PENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAEL 469
            ||||||....||.|:||||||||....|||.||||||||:|||:||..|...||||||||||.|:
 Worm   459 PENVLLVNAKRSQIRVIDFGSSCQTGHRIYQYIQSRFYRSPEVLLGIAYDTKIDMWSLGCILVEM 523

  Fly   470 LSGHALFPGENESDQLACIIEVLGMPNKNIL-ASSKRSKSFFSPKGYPRYCT------------- 520
            .:|..||.|.:|.||:..|:||||||.|.:| ...|..|.|...:....||.
 Worm   524 HTGEPLFAGSSEVDQMMKIVEVLGMPPKEMLDIGPKTHKYFDKTEDGIYYCKKTRDGYRHTYKAP 588

  Fly   521 -VRTMSDGMVVLIGGQSRRGKQRGPP--CSKSLSKALDGCKDPLFLNFIRGCLEWDADKRLTPSE 582
             .|.:.:.:.|..||..  |::.|.|  ..:..||         |.:.|:..|::|..:|::|..
 Worm   589 GARKLHEILGVTSGGPG--GRRLGEPGHSVEDYSK---------FKDLIKRMLQFDPKQRISPYY 642

  Fly   583 ALKHPWLRRRLPRPPSSSSGCGGVSGLCSSRNESPVTGQNRNFAAETTASSTSATSISLTIKREN 647
            .::||:|:::..|.||                :.||
 Worm   643 VVRHPFLKQKEERVPS----------------QPPV----------------------------- 662

  Fly   648 SHSSLRLHHGAV---PETDFKLIKSVPEGSSTATKEPMMNSDILPESFRQTTVVSPSKHSADSGG 709
            |||:|:......   |.:....:...|...|...::..|.......|....:|.|    |.|.|.
 Worm   663 SHSNLQQQQQLYIQQPSSQMSQVMESPSVGSVYVEDNGMYRQAPGSSANPISVTS----SFDEGD 723

  Fly   710 MSCLSAVDVGPSRYYPYMNNNENNRLFSSSLNSSANSLSHLEQATKLD 757
               ...||.|..|:..:..|..|.....|.............|.|:|:
 Worm   724 ---AMEVDAGRRRFSAHQQNYHNPNYQYSQPQQQQQQQYQQTQRTQLE 768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	161/398 (40%)
		S_TKc	276..589	CDD:214567	149/333 (45%)
mbk-1	NP_510460.2	PKc_DYRK1	312..651	CDD:271128	153/349 (44%)
		S_TKc	326..649	CDD:214567	149/333 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D870358at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.850