Protein Alignment Dyrk3 and mbk-2

DIOPT Version :9

• Sequence 1: NP_001033810.1
• Gene: Dyrk3 / 3885567
• FlyBaseID: FBgn0027101
• Length: 828
• Species: Drosophila melanogaster
• Sequence 2: NP_001023207.1
• Gene: mbk-2 / 178250
• WormBaseID: WBGene00003150
• Length: 817
• Species: Caenorhabditis elegans
• Alignment Length: 638
• Identity: 311/638 - (48%)
• Similarity: 388/638 - (60%)
• Gaps: 81/638 - (12%)

  Fly    30 LENTQLSKALSPPTSLPQI--QIQMINQNLTHTGIAQNNTEKANRHQYRDSGLQYLTRCFEPLAM 92
            |:.|..|...:|.:|..|:  |.|.:..|..:       .:...|.|:.:|   :.|:.|
 Worm   211 LQQTASSLYSNPQSSSSQLLGQQQAVRPNYAY-------QQSLPRQQHINS---HQTQAF----- 260

  Fly    93 LNDSKEDF-----PTQPSNNIANYPGDIQILPIFDCCEISESIQAISLPNV-TSPSK-------- 143
                   |     ||..:|.:........::.:......:.:.||..|||| ||.|.
 Worm   261 -------FGTVRGPTNSTNIVTPLRASKTMIDVLAPVRDTVAAQATGLPNVGTSSSNGSSNSSSG 318

  Fly   144 ----------TKDVPG---------LFLRTISE----NSKSKSEPECESLISVKESSVMENHTFL 185
                      |:.:.|         ..|.|.|.    :||....|..|||.....||
 Worm   319 VGSGGSGSLMTQSIGGPNKHLSASHSTLNTASTHDMMHSKIPKSPSNESLSRSHTSS-------- 375

  Fly   186 FHEQIIMSGQQKCELHEKPKVLVVSPQQVMILYMNKLTPYERTEILTYPQIYFIGANAKKRPGVY 250
                  ..|.|..............|:..:..:..||.|:|:.||..|.:::|:|::|||:.||.
 Worm   376 ------SGGSQGGHNSNSGSNSGFRPEDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVI 434

  Fly   251 -GPNNSEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFH 314
             |.||..||:|.|:|..|.|||:|||||:||:||||||||||||:|||..::||||:||||||||
 Worm   435 GGANNGGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFH 499

  Fly   315 RQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLV 379
            |||.||||||.||||.|...|.|||||.|||.||||.||||||||||||||||:|.|:||||.||
 Worm   500 RQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLV 564

  Fly   380 RKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRA 444
            ||||:|:|.|||.|.||.:||||:|||||||||||||||||||||||||::||||||||||||||
 Worm   565 RKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRA 629

  Fly   445 PEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSF 509
            ||||||.|||..||||||||||||||:|:.|.|||:|:||||.|||:||||....|.::||:::|
 Worm   630 PEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTF 694

  Fly   510 FSPKGYPRYCTVRTMSDGMVVLIGGQSRRGKQRGPPCSKSLSKALDGCKDPLFLNFIRGCLEWDA 574
            .:.||||||||..:|.||.|||.|.:|:|||.||||.|:|.|.||....|.||::|::.||:||.
 Worm   695 ITSKGYPRYCTATSMPDGSVVLAGARSKRGKMRGPPASRSWSTALKNMGDELFVDFLKRCLDWDP 759

  Fly   575 DKRLTPSEALKHPWLRRRLPRPPSSSSGCGGVSGLCSSRNES---PVTGQNRN 624
            :.|:||::||||.|||||||.||  ..|...:.||.....::   |....|.|
 Worm   760 ETRMTPAQALKHKWLRRRLPNPP--RDGLESMGGLADHEKKTETLPNIDSNAN 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	254/378 (67%)
		S_TKc	276..589	CDD:214567	224/312 (72%)
mbk-2	NP_001023207.1	PKc_DYRK2_3	395..774	CDD:271126	254/378 (67%)
		S_TKc	461..774	CDD:214567	224/312 (72%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166746
Domainoid	1	1.000	471	1.000	Domainoid score	I213
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H48437
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162948at33208
OrthoFinder	1	1.000	-	-		FOG0000895
OrthoInspector	1	1.000	-	-		oto19079
orthoMCL	1	0.900	-	-		OOG6_100394
Panther	1	1.100	-	-	LDO	PTHR24058
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	1	1.000	-	-		X888
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.880