Protein Alignment Dyrk3 and mbk-2

DIOPT Version :10

• Sequence 1: NP_001033810.1
• Gene: Dyrk3 / 3885567
• FlyBaseID: FBgn0027101
• Length: 828
• Species: Drosophila melanogaster
• Sequence 2: NP_001023207.1
• Gene: mbk-2 / 178250
• WormBaseID: WBGene00003150
• Length: 817
• Species: Caenorhabditis elegans
• Alignment Length: 638
• Identity: 311/638 - (48%)
• Similarity: 388/638 - (60%)
• Gaps: 81/638 - (12%)

  Fly    30 LENTQLSKALSPPTSLPQI--QIQMINQNLTHTGIAQNNTEKANRHQYRDSGLQYLTRCFEPLAM 92
            |:.|..|...:|.:|..|:  |.|.:..|..:       .:...|.|:.:|   :.|:.|
 Worm   211 LQQTASSLYSNPQSSSSQLLGQQQAVRPNYAY-------QQSLPRQQHINS---HQTQAF----- 260

  Fly    93 LNDSKEDF-----PTQPSNNIANYPGDIQILPIFDCCEISESIQAISLPNV-TSPSK-------- 143
                   |     ||..:|.:........::.:......:.:.||..|||| ||.|.
 Worm   261 -------FGTVRGPTNSTNIVTPLRASKTMIDVLAPVRDTVAAQATGLPNVGTSSSNGSSNSSSG 318

  Fly   144 ----------TKDVPG---------LFLRTISE----NSKSKSEPECESLISVKESSVMENHTFL 185
                      |:.:.|         ..|.|.|.    :||....|..|||.....||
 Worm   319 VGSGGSGSLMTQSIGGPNKHLSASHSTLNTASTHDMMHSKIPKSPSNESLSRSHTSS-------- 375

  Fly   186 FHEQIIMSGQQKCELHEKPKVLVVSPQQVMILYMNKLTPYERTEILTYPQIYFIGANAKKRPGVY 250
                  ..|.|..............|:..:..:..||.|:|:.||..|.:::|:|::|||:.||.
 Worm   376 ------SGGSQGGHNSNSGSNSGFRPEDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVI 434

  Fly   251 -GPNNSEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFH 314
             |.||..||:|.|:|..|.|||:|||||:||:||||||||||||:|||..::||||:||||||||
 Worm   435 GGANNGGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFH 499

  Fly   315 RQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLV 379
            |||.||||||.||||.|...|.|||||.|||.||||.||||||||||||||||:|.|:||||.||
 Worm   500 RQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLV 564

  Fly   380 RKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRA 444
            ||||:|:|.|||.|.||.:||||:|||||||||||||||||||||||||::||||||||||||||
 Worm   565 RKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRA 629

  Fly   445 PEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSF 509
            ||||||.|||..||||||||||||||:|:.|.|||:|:||||.|||:||||....|.::||:::|
 Worm   630 PEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTF 694

  Fly   510 FSPKGYPRYCTVRTMSDGMVVLIGGQSRRGKQRGPPCSKSLSKALDGCKDPLFLNFIRGCLEWDA 574
            .:.||||||||..:|.||.|||.|.:|:|||.||||.|:|.|.||....|.||::|::.||:||.
 Worm   695 ITSKGYPRYCTATSMPDGSVVLAGARSKRGKMRGPPASRSWSTALKNMGDELFVDFLKRCLDWDP 759

  Fly   575 DKRLTPSEALKHPWLRRRLPRPPSSSSGCGGVSGLCSSRNES---PVTGQNRN 624
            :.|:||::||||.|||||||.||  ..|...:.||.....::   |....|.|
 Worm   760 ETRMTPAQALKHKWLRRRLPNPP--RDGLESMGGLADHEKKTETLPNIDSNAN 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	254/378 (67%)
mbk-2	NP_001023207.1	PKc_DYRK2_3	395..774	CDD:271126	254/378 (67%)