DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dyrk3 and Clk3

DIOPT Version :9

Sequence 1:	NP_001033810.1	Gene:	Dyrk3 / 3885567	FlyBaseID:	FBgn0027101	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_006243208.1	Gene:	Clk3 / 171305	RGDID:	621259	Length:	640	Species:	Rattus norvegicus

Alignment Length:	394	Identity:	120/394 - (30%)
Similarity:	193/394 - (48%)	Gaps:	43/394 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 ANAKKRPGVYGPNNSEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDH-KTHEHVAL 304
            |:::.:......:.|..|:::|..:....|.:..|||::..:|:|:||:|::..|| :....|||
  Rat   271 ASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVAL 335

  Fly   305 KIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKN 369
            ||:||..::...|:.||.:|..::..||.|....:.|.|:|.|..|.||.||||..|.:|.:|:|
  Rat   336 KIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKEN 400

  Fly   370 GFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLL-----------------KQQGRSG 417
            .|:.:.|..||..|:.|...|..|::|.:.|.|:||||:|.                 |....:.
  Rat   401 NFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTS 465

  Fly   418 IKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENES 482
            |:|.||||:.|:::...|.:.:|.||.|||||...:.:..|:||:||||.|...|..||......
  Rat   466 IRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENR 530

  Fly   483 DQLACIIEVLGMPNKNILASSKRSKSFFSPKGYPRYCTVRTMSDGMVVLIGGQSRRGKQRGPPCS 547
            :.|..:.::||....:::..:::.|.|:  ||  ........|||..|         |:...|..
  Rat   531 EHLVMMEKILGPIPSHMIHRTRKQKYFY--KG--GLVWDENSSDGRYV---------KENCKPLK 582

  Fly   548 KSLSKALDGCKDPLFLNFIRGCLEWDADKRLTPSEALKHPWLRRRLPRPPSSSSGCGGVSGLCSS 612
            ..:.:  |..:.....:.:|..||:|..:|:|.:|||.||:.....|...|          ..||
  Rat   583 SYMLQ--DSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERS----------FHSS 635

  Fly   613 RNES 616
            ||.|
  Rat   636 RNPS 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	113/365 (31%)
Dyrk3	NP_001033810.1	S_TKc	276..589	CDD:214567	107/330 (32%)
Clk3	XP_006243208.1	PHA03247	29..>162	CDD:223021
Clk3	XP_006243208.1	PKc_CLK3	292..622	CDD:271116	110/344 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810