DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk3 and Hipk3

DIOPT Version :9

Sequence 1:	NP_001033810.1	Gene:	Dyrk3 / 3885567	FlyBaseID:	FBgn0027101	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_034564.2	Gene:	Hipk3 / 15259	MGIID:	1314882	Length:	1192	Species:	Mus musculus

Alignment Length:	725	Identity:	182/725 - (25%)
Similarity:	302/725 - (41%)	Gaps:	153/725 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 MSGQQKCELHEKPKVLVVSPQQVMILYMNKLTPYERTEILTYPQIYFIGANAKKRPGVYGPNNSE 256
            :.|.|:|.|..|.:.|......:.|:....:.|......:..|..........|:....|
Mouse   119 LEGPQRCGLKRKSEELENHSGAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTSG----- 178

  Fly   257 YDNEQGAYIHVPHD---HVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQ 318
                :|.|..|.|:   .:...||:|..:|:|:||||:|.:...|:|.||:||::|...:.||.|
Mouse   179 ----EGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQ 239

  Fly   319 EEIRILHHL--RRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRK 381
            .|:.||..|  ...|:|   |.:..::.|..|||||:.||:|..|||:.:|:|.|....|:::|.
Mouse   240 IEVSILARLSTENADEY---NFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRP 301

  Fly   382 FAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRS--GIKVIDFGSSCFENQRI-YTYIQSRFYR 443
            ....:...|..|....:||.|:||||::|....|.  .:|||||||:...::.: .||:|||:||
Mouse   302 VLQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYR 366

  Fly   444 APEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKS 508
            |||:|||..:..|||||||||::|||..|..|:||..|.||:..|.:..|:|.:.:|....:|..
Mouse   367 APEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTR 431

  Fly   509 FFSPKGYPRYCTVRTMSDG---MVVLIGGQSRRGKQRGPPCSKSLSKALDGCKDPL--------- 561
            ||        |....||..   :..|...::..|.:     ||...|.:....|.:
Mouse   432 FF--------CRETDMSHSGWRLKTLEEHEAETGMK-----SKEARKYIFNSLDDIVHVNTVMDL 483

  Fly   562 --------------FLNFIRGCLEWDADKRLTPSEALKHPW--LRRRLPRPPSSS-SGCGGVSGL 609
                          |:|.::..|..|||.|:||.|.|.||:  ::..|..|.|:. ..|..:..:
Mouse   484 EGGDLLAEKADRREFVNLLKKMLLIDADLRITPIETLNHPFVNMKHLLDFPHSNHVKSCFHIMDI 548

  Fly   610 CSSRNESPVTGQNR---------NFAAETTASSTSATSISLTIKRENSHSSLRLHHG-------- 657
            |.|.:.......::         |..|...|:.|...::.......::||.  :|||
Mouse   549 CKSPSSCETNNHSKMSLLRPVASNGTAALAANFTKVGTLRSQALTTSAHSV--VHHGIPLQAGTA 611

  Fly   658 --------------------AVPET-------DFKLIKSVPEGSSTATKEPMM------------ 683
                                .:|..       ..::..:||..:.....:|:.
Mouse   612 QFGCGDAFHQTLIICPPAIQGIPAAHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLSQQTWS 676

  Fly   684 --NSDILPESFRQTTVVSPSKHSADSGGMSCLSAV-DVGPSRYYPYMNNNEN--------NRLFS 737
              ...:|..:::|.|.::|:..:..|.||:....: |.|  :..|:.|:..:        |::..
Mouse   677 GRTQQMLIPAWQQVTPMAPAAATLTSEGMAGSQRLGDWG--KMIPHSNHYNSVMPPPLLTNQITL 739

  Fly   738 SSLNSSANSLSHLEQATKLDALGEYSASTTPNLLSKNTGYSFNSGSI------------NIDVAQ 790
            |:....:..::|:        :....|:|..|.|.:|...|..:.:|            ..:|.:
Mouse   740 SAPQPISVGIAHV--------VWPQPATTKKNKLCQNRSNSLQNTNIPHSAFISPKIISGKEVEE 796

  Fly   791 ESLVNIASNY 800
            .|.|:...|:
Mouse   797 VSCVDTQDNH 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	132/413 (32%)
Dyrk3	NP_001033810.1	S_TKc	276..589	CDD:214567	123/345 (36%)
Hipk3	NP_034564.2	PKc_like	196..525	CDD:304357	123/344 (36%)
		S_TKc	197..525	CDD:214567	123/343 (36%)
		Interaction with AR. /evidence=ECO:0000250	767..921		7/40 (18%)
		Interaction with FAS. /evidence=ECO:0000269\|PubMed:11034606	775..868		5/32 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	799..829		2/8 (25%)
		Required for localization to nuclear speckles. /evidence=ECO:0000250	832..988
		SUMO interaction motifs (SIM), required for nuclear localization and kinase activity. /evidence=ECO:0000250	843..895
		Interaction with UBL1. /evidence=ECO:0000250	847..857
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	889..943
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	956..1023
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840