DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk3 and Hipk1

DIOPT Version :9

Sequence 1:	NP_001033810.1	Gene:	Dyrk3 / 3885567	FlyBaseID:	FBgn0027101	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001288233.1	Gene:	Hipk1 / 15257	MGIID:	1314873	Length:	1210	Species:	Mus musculus

Alignment Length:	683	Identity:	195/683 - (28%)
Similarity:	313/683 - (45%)	Gaps:	124/683 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 SNNIANYPGDIQILPIFDCCEISESIQAISLPNVTSPSKTKDVPGL--FLRTISENSKSKSEPEC 167
            |:.:||:.     ||.:|        |.:.||          .|.:  .:.|.:::|.|.:....
Mouse    59 SHQVANFN-----LPAYD--------QGLLLP----------APAVEHIVVTAADSSGSAATATF 100

  Fly   168 ESLISVKESSVMENHTFLFHEQIIMSGQQKCELHEKPKVLVVSPQQVMILYMNKLTPYERTEILT 232
            :|..::...|.:.          ::...|||.|..|.:. |.|...|.|:        |....|.
Mouse   101 QSSQTLTHRSNVS----------LLEPYQKCGLKRKSEE-VESNGSVQII--------EEHPPLM 146

  Fly   233 YPQIYFIGANAKKRPGVYGPNNSEYDNEQGAYIHVPHD---HVAYRYEMLKIIGKGSFGQVIKAY 294
            ......:||.|......   ..|...:.:|.|..|.|:   .:...||:|:.:|:|:||||.|.:
Mouse   147 LQNRTVVGAAATTTTVT---TKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCW 208

  Fly   295 DHKTHEHVALKIVRNEKRFHRQAQEEIRILHHL--RRHDKYNTMNIIHMFDYFTFRNHTCITFEL 357
            ...|.|.||:||::|...:.||.|.|:.||..|  ...|:|   |.:..::.|..:||||:.||:
Mouse   209 KRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEY---NFVRSYECFQHKNHTCLVFEM 270

  Fly   358 LSINLYELIKKNGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRS--GIKV 420
            |..|||:.:|:|.|....|:.:|.....:...|..|....:||.|:||||::|....|.  .:||
Mouse   271 LEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKV 335

  Fly   421 IDFGSSCFENQRI-YTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQ 484
            |||||:...::.: .||:|||:|||||:|||..:..|||||||||::|||..|..|:||.:|.||
Mouse   336 IDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQ 400

  Fly   485 LACIIEVLGMPNKNILASSKRSKSFFS--PK-GYPRYCTVRTMSDGMVVLIGGQSRRGKQRGPPC 546
            :..|.:..|:|.:.:|::..::..||:  |. |||.: .::|..:..:. .|.:|:..::....|
Mouse   401 IRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLW-RLKTPEEHELE-TGIKSKEARKYIFNC 463

  Fly   547 -----SKSLSKALDGCKDPL--------FLNFIRGCLEWDADKRLTPSEALKHPW--LRRRLPRP 596
                 ..::|..|:| .|.|        :::.::..|..|||||:||.:.|.|.:  :...|..|
Mouse   464 LDDMAQVNMSTDLEG-TDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMSHLLDFP 527

  Fly   597 PSSS-SGCGGVSGLCSSR----------------NESPVTGQN------------RNFAAETTAS 632
            .||. ..|.....:|..|                :.:|.|..|            .|.|:...:|
Mouse   528 HSSHVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASS 592

  Fly   633 STSATSISLTIKRENSHSSLRLHHGA--------VPETDFKLIKSVPEGSSTATK-EPMMNSDIL 688
            ||:|.:   |:...||..||..:..|        ||....:.:...|..:...|: :|...:.|:
Mouse   593 STAAAA---TLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIV 654

  Fly   689 -PESFRQTTVVSPSKHSADSGGMSCLSAVDVGP 720
             |.:| ||.:.:.:|||.....|.  :||.:.|
Mouse   655 CPPAF-QTGLQATTKHSGFPVRMD--NAVPIVP 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	134/403 (33%)
Dyrk3	NP_001033810.1	S_TKc	276..589	CDD:214567	122/335 (36%)
Hipk1	NP_001288233.1	STKc_HIPK1	174..528	CDD:271130	126/359 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	835..856
		Nuclear localization signal 1 (NLS1). /evidence=ECO:0000250	844..847
		Interaction with TP53. /evidence=ECO:0000269\|PubMed:12702766	885..1093
		Required for localization to nuclear speckles. /evidence=ECO:0000250	891..998
		SUMO interaction motifs (SIM), required for nuclear localization and kinase activity. /evidence=ECO:0000250	902..926
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	938..981
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1046..1069
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1084..1104
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840