Protein Alignment Dyrk3 and HIPK4

DIOPT Version :9

• Sequence 1: NP_001033810.1
• Gene: Dyrk3 / 3885567
• FlyBaseID: FBgn0027101
• Length: 828
• Species: Drosophila melanogaster
• Sequence 2: XP_006723099.1
• Gene: HIPK4 / 147746
• HGNCID: 19007
• Length: 619
• Species: Homo sapiens
• Alignment Length: 595
• Identity: 153/595 - (25%)
• Similarity: 249/595 - (41%)
• Gaps: 130/595 - (21%)

  Fly   276 YEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIH 340
            |::::::|||:||:|.|.:...|.|.||:||::|:...:|..:.|:::||.:|..|. ...::|.
Human    11 YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDP-EEAHVIR 74

  Fly   341 MFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKP 405
            ..::|.......:.||||..||:|..|:|.|.....:.:|.....:|..|..|.:..|||.|:||
Human    75 FLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLKELAIIHADLKP 139

  Fly   406 ENVLLKQQGRS--GIKVIDFGSSCFENQRIYT---YIQSRFYRAPEVILGGKYGRAIDMWSLGCI 465
            ||::|..|.|.  .:|||||||:...::..|.   |||||||||||::||..:...:|:|||||:
Human   140 ENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWSLGCV 204

  Fly   466 LAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFFSPKGYPRYCTVRTMSDGMVV 530
            :|||..|..|:||.||.||:..|.|..|:|..::|.::.::..||....:|.......:......
Human   205 MAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADY 269

  Fly   531 LIGGQSRRGKQRGPPCSKSLSKALDGC----------------KDPL--------FLNFIRGCLE 571
            |...:.|..::|     |.:.|:||..                ::.|        .:..|:..|.
Human   270 LAETKVRPLERR-----KYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVELIKRMLT 329

  Fly   572 WDADKRLTPSEALKHPWLRRRLPR-------------------------PPS------------- 598
            |::.:|::||.||:||::..:..|                         ||:
Human   330 WESHERISPSAALRHPFVSMQQLRSAHETTHYYQLSLRSYRLSLQVEGKPPTPVVAAEDGTPYYC 394

  Fly   599 -----SSSGCGGVSGLCSSRNESPVTGQNR---------------NFAAETTASSTSATSISLTI 643
                 .::|.|.|:|......|....|..|               ....||..::.|...:.|
Human   395 LAEEKEAAGMGSVAGSSPFFREEKAPGMQRAIDQLDDLSLQEAGHGLWGETCTNAVSDMMVPL-- 457

  Fly   644 KRENSHSSLRLHH--GAVPETDFKLIKSVPEGSSTATKEPMMNSDILPESFRQTTVVSPSKHSAD 706
                 .:::..||  .:.||.......|...|...|.|.|                 :.||  :|
Human   458 -----KAAITGHHVPDSGPEPILAFYSSRLAGRHKARKPP-----------------AGSK--SD 498

  Fly   707 SGGMSCLSAVDVGPSRYYPYMNNNENNRLFSSSLNSSANSLSHL---EQATKLDAL---GEYSAS 765
            |...:.:....|.|....|...::...   ...|.:||..|:.|   |....:|.:   .|.|..
Human   499 SNFSNLIRLSQVSPEDDRPCRGSSWEE---GEHLGASAEPLAILQRDEDGPNIDNMTMEAEVSRR 560

  Fly   766 TTPNLLSKNT 775
            ..|.|...::
Human   561 PDPELFDPSS 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	112/341 (33%)
		S_TKc	276..589	CDD:214567	112/341 (33%)
HIPK4	XP_006723099.1	PKc_like	11..347	CDD:304357	112/341 (33%)
		S_TKc	11..347	CDD:214567	112/341 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155022
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740