Protein Alignment Dyrk3 and Dyrk1a

DIOPT Version :10

• Sequence 1: NP_001033810.1
• Gene: Dyrk3 / 3885567
• FlyBaseID: FBgn0027101
• Length: 828
• Species: Drosophila melanogaster
• Sequence 2: NP_031916.1
• Gene: Dyrk1a / 13548
• MGIID: 1330299
• Length: 763
• Species: Mus musculus
• Alignment Length: 733
• Identity: 230/733 - (31%)
• Similarity: 346/733 - (47%)
• Gaps: 137/733 - (18%)

  Fly   174 KESSVMENHTFLFH-------------------EQIIMSGQQKCELHEKPKVLVVSPQQVM--IL 217
            |.|||....:|.||                   .|..:|.||...|....::......|||  |:
Mouse    11 KPSSVRLAPSFSFHAAGLQMAAQMPHSHQYSDRRQPSISDQQVSALPYSDQIQQPLTNQVMPDIV 75

  Fly   218 YMNKLTPYERTEILTYP----------------QIYFI------------GANAKKRPGVYGPNN 254
            .:.:..|....:..|.|                ::|:.            .::.||...||   |
Mouse    76 MLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVY---N 137

  Fly   255 SEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQE 319
            ..||::...||....:....|||:..:|||||||||:||||....|.||:||::|:|.|..|||.
Mouse   138 DGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQI 202

  Fly   320 EIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAH 384
            |:|:|..:.:||......|:|:..:|.||||.|:.||:||.|||:|::...|:|.||.|.||||.
Mouse   203 EVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQ 267

  Fly   385 SLLQCLDALY----KNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRAP 445
            .:  |...|:    :..|||||:||||:||....||.||::||||||...||||.||||||||:|
Mouse   268 QM--CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSP 330

  Fly   446 EVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFF 510
            ||:||..|..|||||||||||.|:.:|..||.|.||.||:..|:||||:|..:||..:.:::.||
Mouse   331 EVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395

  Fly   511 S--PKGYPRYCTVRTMSDGMVVLIGGQSRR-----GKQRGPPCSKSLSKALDGCKDPL-FLNFIR 567
            .  |.|   ..:::...||........:|:     |.:.|.|..:...::.....|.| |.:.|.
Mouse   396 EKLPDG---TWSLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLIL 457

  Fly   568 GCLEWDADKRLTPSEALKHPWLRRRLPRPPSSSSGCGGVSGLCSSRNESPVTGQNRNFAAETTAS 632
            ..|::|...|:.|..||:|.:.::......::|          :|.:.||...|:::....::.|
Mouse   458 RMLDYDPKTRIQPYYALQHSFFKKTADEGTNTS----------NSVSTSPAMEQSQSSGTTSSTS 512

  Fly   633 S----TSATSISLTIKRENSHSSLRLHHG-----AVP----ETDFKLIKS---VPEGSSTATKEP 681
            |    :|.||.|...:.:.:|.  ..|.|     ||.    ||....::.   .|.|.| .|:.|
Mouse   513 SSSGGSSGTSNSGRARSDPTHQ--HRHSGGHFAAAVQAMDCETHSPQVRQQFPAPLGWS-GTEAP 574

  Fly   682 MMNSDILPES--FRQTTV-VSPSK-----HSADSGGMSCLSAVDVGPSRYYPY------------ 726
               :.:..|:  .::||. |:|.:     |..:|             |.::.:
Mouse   575 ---TQVTVETHPVQETTFHVAPQQNALHHHHGNS-------------SHHHHHHHHHHHHHGQQA 623

  Fly   727 MNNNENNRLFSSSLNSSANSLSHLEQATKLDALGEYSASTT-PNLLSKNTGYSFNSGSINIDVAQ 790
            :.|....|:::|..|||:...| :|......::...|:||| .:..|.:||...|....|..||.
Mouse   624 LGNRTRPRVYNSPTNSSSTQDS-MEVGHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQNRPVAA 687

  Fly   791 ESLVNIASNYALDKSIDI 808
            .:| :...|.|:|.::.:
Mouse   688 NTL-DFGQNGAMDVNLTV 704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	164/419 (39%)
Dyrk1a	NP_031916.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	33..61		5/27 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..136		2/20 (10%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	117..134		2/16 (13%)
		PKc_DYRK1	148..484	CDD:271128	148/340 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	408..442		6/33 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	485..540		13/66 (20%)
		Histidine-rich domain (HRD). /evidence=ECO:0000250|UniProtKB:Q13627	595..625		3/42 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	596..679		19/96 (20%)