DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dyrk3 and Dyrk1a

DIOPT Version :9

Sequence 1:NP_001033810.1 Gene:Dyrk3 / 3885567 FlyBaseID:FBgn0027101 Length:828 Species:Drosophila melanogaster
Sequence 2:NP_001106860.1 Gene:Dyrk1a / 13548 MGIID:1330299 Length:763 Species:Mus musculus


Alignment Length:731 Identity:228/731 - (31%)
Similarity:342/731 - (46%) Gaps:133/731 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   174 KESSVMENHTFLFH-------------------EQIIMSGQQKCELHEKPKVLVVSPQQVM--IL 217
            |.|||....:|.||                   .|..:|.||...|....::......|||  |:
Mouse    11 KPSSVRLAPSFSFHAAGLQMAAQMPHSHQYSDRRQPSISDQQVSALPYSDQIQQPLTNQVMPDIV 75

  Fly   218 YMNKLTPYERTEILTYP----------------QIYFI------------GANAKKRPGVYGPNN 254
            .:.:..|....:..|.|                ::|:.            .::.||...||   |
Mouse    76 MLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVY---N 137

  Fly   255 SEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQE 319
            ..||::...||....:....|||:..:|||||||||:||||....|.||:||::|:|.|..|||.
Mouse   138 DGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQI 202

  Fly   320 EIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAH 384
            |:|:|..:.:||......|:|:..:|.||||.|:.||:||.|||:|::...|:|.||.|.||||.
Mouse   203 EVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQ 267

  Fly   385 SLLQCLDALY----KNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRAP 445
            .:  |...|:    :..|||||:||||:||....||.||::||||||...||||.||||||||:|
Mouse   268 QM--CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSP 330

  Fly   446 EVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFF 510
            ||:||..|..|||||||||||.|:.:|..||.|.||.||:..|:||||:|..:||..:.:::.||
Mouse   331 EVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395

  Fly   511 S--PKGYPRYCTVRTMSDGMVVLIGGQSRR-----GKQRGPPCSKSLSKALDGCKDPL-FLNFIR 567
            .  |.|   ..:::...||........:|:     |.:.|.|..:...::.....|.| |.:.|.
Mouse   396 EKLPDG---TWSLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLIL 457

  Fly   568 GCLEWDADKRLTPSEALKHPWLRRRLPRPPSSSSGCGGVSGLCSSRNESPVTGQNRNFAAETTAS 632
            ..|::|...|:.|..||:|.:.::......::|          :|.:.||...|:::....::.|
Mouse   458 RMLDYDPKTRIQPYYALQHSFFKKTADEGTNTS----------NSVSTSPAMEQSQSSGTTSSTS 512

  Fly   633 S----TSATSISLTIKRENSHSSLRLHHG-----AVP----ETDFKLIKS---VPEGSSTATKEP 681
            |    :|.||.|...:.:.:|.  ..|.|     ||.    ||....::.   .|.|.|......
Mouse   513 SSSGGSSGTSNSGRARSDPTHQ--HRHSGGHFAAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPT 575

  Fly   682 MMNSDILPESFRQTTV-VSPSK-----HSADSGGMSCLSAVDVGPSRYYPY------------MN 728
            .:..:..|  .::||. |:|.:     |..:|             |.::.:            :.
Mouse   576 QVTVETHP--VQETTFHVAPQQNALHHHHGNS-------------SHHHHHHHHHHHHHGQQALG 625

  Fly   729 NNENNRLFSSSLNSSANSLSHLEQATKLDALGEYSASTT-PNLLSKNTGYSFNSGSINIDVAQES 792
            |....|:::|..|||:...| :|......::...|:||| .:..|.:||...|....|..||..:
Mouse   626 NRTRPRVYNSPTNSSSTQDS-MEVGHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQNRPVAANT 689

  Fly   793 LVNIASNYALDKSIDI 808
            | :...|.|:|.::.:
Mouse   690 L-DFGQNGAMDVNLTV 704

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dyrk3NP_001033810.1 PKc_DYRK2_3 211..589 CDD:271126 164/419 (39%)
S_TKc 276..589 CDD:214567 146/324 (45%)
Dyrk1aNP_001106860.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 33..61 5/27 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 115..136 2/20 (10%)
Bipartite nuclear localization signal. /evidence=ECO:0000255 117..134 2/16 (13%)
PKc_DYRK1 148..484 CDD:271128 148/340 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 408..442 6/33 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 485..540 13/66 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 596..679 19/96 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0667
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R968
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.840

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