DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dyrk3 and Clk2

DIOPT Version :9

Sequence 1:	NP_001033810.1	Gene:	Dyrk3 / 3885567	FlyBaseID:	FBgn0027101	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_031738.2	Gene:	Clk2 / 12748	MGIID:	1098669	Length:	499	Species:	Mus musculus

Alignment Length:	361	Identity:	114/361 - (31%)
Similarity:	189/361 - (52%)	Gaps:	35/361 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 DNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKT-HEHVALKIVRNEKRFHRQAQEEI 321
            |:.:|..|:...|.:..|||::..:|:|:||:|::..||:. ...|||||::|.:::...|:.||
Mouse   144 DDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGTQVALKIIKNVEKYKEAARLEI 208

  Fly   322 RILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAHSL 386
            .:|..:...|..|....:.|||:|.:..|.||:||||.::.::.:|.|.:..:.:..||..|..|
Mouse   209 NVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQL 273

  Fly   387 LQCLDALYKNDIIHCDMKPENVLL-------------KQQGRS----GIKVIDFGSSCFENQRIY 434
            .|.:..|:.|.:.|.|:||||:|.             |:..||    .::|:||||:.|:::...
Mouse   274 CQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHS 338

  Fly   435 TYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNI 499
            |.:.:|.||||||||...:.:..|:||:|||:.|...|..||...:..:.||.:..:||.....:
Mouse   339 TIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPVPSRM 403

  Fly   500 LASSKRSKSFFSPKGYPRYCTVRTMSDGMVVLIGGQSRRGKQRGPPCSKSL-SKALDGCKDPLFL 563
            :..:::.|.|:  :|  |.......|.|..|         ::...|..:.| |:|.|  ...||
Mouse   404 IRKTRKQKYFY--RG--RLDWDENTSAGRYV---------RENCKPLRRYLTSEAED--HHQLF- 452

  Fly   564 NFIRGCLEWDADKRLTPSEALKHPWLRRRLPRPPSS 599
            :.|...||::..||||..|||:||:.......||::
Mouse   453 DLIENMLEYEPAKRLTLGEALQHPFFACLRTEPPNT 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	112/349 (32%)
Dyrk3	NP_001033810.1	S_TKc	276..589	CDD:214567	107/331 (32%)
Clk2	NP_031738.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..65
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	102..142
		PKc_CLK2	149..478	CDD:271117	110/344 (32%)
		S_TKc	162..478	CDD:214567	107/331 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810