DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dyrk3 and Clk1

DIOPT Version :9

Sequence 1:	NP_001033810.1	Gene:	Dyrk3 / 3885567	FlyBaseID:	FBgn0027101	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001036099.1	Gene:	Clk1 / 12747	MGIID:	107403	Length:	483	Species:	Mus musculus

Alignment Length:	366	Identity:	124/366 - (33%)
Similarity:	199/366 - (54%)	Gaps:	39/366 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 ANAKKRPGVYGPNNSEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKT-HEHVAL 304
            ::.:||      :.|..|:|:|..|....|.::.|||::..:|:|:||:|::..|||. ...||:
Mouse   131 SHRRKR------SRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKVGGRRVAV 189

  Fly   305 KIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKN 369
            |||:|..|:...||.||::|.||...|.::|...:.|.::|..|.|.||.||||.::.|:.||:|
Mouse   190 KIVKNVDRYCEAAQSEIQVLEHLNTTDPHSTFRCVQMLEWFEHRGHICIVFELLGLSTYDFIKEN 254

  Fly   370 GFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVL-------------LKQQGRS----G 417
            .|..|.:..:||.|:.:.:.::.|:.|.:.|.|:||||:|             :|:..|:    .
Mouse   255 SFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVKSDYTEAYNPKMKRDERTIVNPD 319

  Fly   418 IKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENES 482
            |||:||||:.::::...|.:.:|.||||||||...:.:..|:||:||||.|...|..:||..:..
Mouse   320 IKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSR 384

  Fly   483 DQLACIIEVLGMPNKNILASSKRSKSFFSPKGYPRYCTVRTMSDGMVVLIGGQSRRGKQRGPPCS 547
            :.||.:..:||...|:::..:::.:.|.    :.|.......|.|..|     |||.|   |...
Mouse   385 EHLAMMERILGPLPKHMIQKTRKRRYFH----HDRLDWDEHSSAGRYV-----SRRCK---PLKE 437

  Fly   548 KSLSKALDGCKDPLFLNFIRGCLEWDADKRLTPSEALKHPW 588
            ..||:   ..:..|..:.|...||:|..||:|..||||||:
Mouse   438 FMLSQ---DAEHELLFDLIGKMLEYDPAKRITLKEALKHPF 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	124/366 (34%)
Dyrk3	NP_001033810.1	S_TKc	276..589	CDD:214567	115/331 (35%)
Clk1	NP_001036099.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49
		Nuclear localization signal. /evidence=ECO:0000255	29..33
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..146		5/20 (25%)
		PKc_CLK1_4	147..476	CDD:271115	118/344 (34%)
		S_TKc	160..476	CDD:214567	115/331 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810