Protein Alignment Dyrk3 and CLK1

DIOPT Version :9

• Sequence 1: NP_001033810.1
• Gene: Dyrk3 / 3885567
• FlyBaseID: FBgn0027101
• Length: 828
• Species: Drosophila melanogaster
• Sequence 2: NP_001155879.1
• Gene: CLK1 / 1195
• HGNCID: 2068
• Length: 526
• Species: Homo sapiens
• Alignment Length: 366
• Identity: 127/366 - (34%)
• Similarity: 202/366 - (55%)
• Gaps: 39/366 - (10%)

  Fly   241 ANAKKRPGVYGPNNSEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKT-HEHVAL 304
            ::.:||      ..|..|:|:|..|....|.::.|||::..:|:|:||:|::..|||. ..|||:
Human   174 SHRRKR------TRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAV 232

  Fly   305 KIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKN 369
            |||:|..|:...|:.||::|.||...|..:|...:.|.::|....|.||.||||.::.|:.||:|
Human   233 KIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKEN 297

  Fly   370 GFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVL-------------LKQQGRS----G 417
            ||..|.|..:||.|:.:.:.::.|:.|.:.|.|:||||:|             :|:..|:    .
Human   298 GFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPD 362

  Fly   418 IKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENES 482
            |||:||||:.::::...|.:.:|.||||||||...:.:..|:||:||||.|...|..:||..:..
Human   363 IKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSK 427

  Fly   483 DQLACIIEVLGMPNKNILASSKRSKSFFSPKGYPRYCTVRTMSDGMVVLIGGQSRRGKQRGPPCS 547
            :.||.:..:||...|:::..:::.|.|.    :.|.......|.|..|     |||.|   |...
Human   428 EHLAMMERILGPLPKHMIQKTRKRKYFH----HDRLDWDEHSSAGRYV-----SRRCK---PLKE 480

  Fly   548 KSLSKALDGCKDPLFLNFIRGCLEWDADKRLTPSEALKHPW 588
            ..||:.::  .:.|| :.|:..||:|..||:|..||||||:
Human   481 FMLSQDVE--HERLF-DLIQKMLEYDPAKRITLREALKHPF 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	127/366 (35%)
		S_TKc	276..589	CDD:214567	118/331 (36%)
CLK1	NP_001155879.1	PKc_CLK1_4	190..519	CDD:271115	121/344 (35%)
		S_TKc	203..519	CDD:214567	118/331 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810