Protein Alignment Dyrk3 and Dyrk4

DIOPT Version :10

• Sequence 1: NP_001033810.1
• Gene: Dyrk3 / 3885567
• FlyBaseID: FBgn0027101
• Length: 828
• Species: Drosophila melanogaster
• Sequence 2: XP_011239406.1
• Gene: Dyrk4 / 101320
• MGIID: 1330292
• Length: 685
• Species: Mus musculus
• Alignment Length: 730
• Identity: 272/730 - (37%)
• Similarity: 385/730 - (52%)
• Gaps: 132/730 - (18%)

  Fly    16 ETPATDKNNLNTTHL---ENTQLSKALSPPTSLPQIQIQMINQNLTHTGIAQNNTEKANRHQYRD 77
            :|....|.:|.|..:   ...|...::..||..|:|.: :.::.|.|.....:..:|..
Mouse    60 DTNKARKRSLTTFPILKARKKQSFTSVKGPTLPPEIYM-VESKPLGHLQKPSSKNKKLR------ 117

  Fly    78 SGLQYLTRCFEPLAMLNDSKEDFP---TQPSNNIANYPGDIQILPIFDCCEISESIQAISLPNVT 139
                 :.||.:.:    .|...||   |:...|..|:|.....:|.....:..|:  .|....::
Mouse   118 -----VNRCPQKI----PSNTAFPFVDTKGKRNTVNFPQIGNKVPSKGPMQYQEN--QIHNQVLS 171

  Fly   140 SPSKTKDVPGLFLRTISENSK---SKSEPECESLISVKESSVMENHTFLFHEQIIMSGQQKCELH 201
            |..||.::|      .:.|:|   :|..|                                 ||.
Mouse   172 SELKTSEIP------FNINTKAQDTKPHP---------------------------------ELQ 197

  Fly   202 EKPKV-LVVSPQQVMILYMNKLTPYERTEILTYPQIYFIGANAKKRPGVYGP---NNSEYDNEQG 262
            :|.|| |.|:  :.:..:.|:|:|||::|||.|.:::|:|..|||...|  |   :.:.:|:|.|
Mouse   198 KKHKVPLTVA--EALKFFKNQLSPYEQSEILGYSELWFLGLEAKKLNVV--PEKFSKTSFDDEHG 258

  Fly   263 AYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHL 327
            :|:.|.|||:|||||:|::|||||||||.|..|||.:|.|||||:||:||||.||..|::||..|
Mouse   259 SYMKVLHDHIAYRYEVLEMIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHHQALVELKILEAL 323

  Fly   328 RRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAHSLLQCLDA 392
            ||.||.|..|::||.|:|.||||.|||||||.||||||:|.|.|.||:|.:||:|..|:|:||..
Mouse   324 RRKDKDNNHNVVHMKDFFYFRNHLCITFELLGINLYELMKNNSFHGFNLSIVRRFTFSILKCLHM 388

  Fly   393 LYKNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAI 457
            ||...|||||:||||::|.|:|:..:|||||||||:|:|::||||||||||:||||||..|..||
Mouse   389 LYVEKIIHCDLKPENIVLYQRGQVTVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYNMAI 453

  Fly   458 DMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFFSPKGYPRYCTVR 522
            ||||||||:|||.:|:.|||||||.:|||||:||||:|..:...::.|.:.||..||.|:..
Mouse   454 DMWSLGCIMAELYTGYPLFPGENEVEQLACIMEVLGLPPAHFTQTASRRQVFFDSKGLPKNI--- 515

  Fly   523 TMSDGMVVLIGGQSRRGKQRGPPCSKSLSKALDGCKDPLFLNFIRGCLEWDADKRLTPSEALKHP 587
                        .:.||.:|.|. ||.|:..:. ..|..||:|:|.||.|:...|:||.:||||.
Mouse   516 ------------NNNRGGKRYPD-SKDLTMVVK-TYDSSFLDFLRRCLVWEPSLRMTPEQALKHA 566

  Fly   588 WL---RRRLPRPPSSSSGCGGVSGLCSSRNESPVTGQNRNFAAETTASSTSATSISLTIKRENSH 649
            |:   |:..|||                         ......:..||.:|..|   |.|.|...
Mouse   567 WIHEPRKFKPRP-------------------------KPQILRKPGASISSEIS---TEKAEEQQ 603

  Fly   650 SSLRLHHGAVPETDFKLIKSVPE------GSSTATKEPMMNSDILP---ESFRQTTVVSPSKHSA 705
            :|......|..||..|| |...|      |...::.|...::..||   |:..::..|:.|:.||
Mouse   604 ASKGKKDEATKETTDKL-KDEAEKHLENSGKQQSSVEHTADTIQLPHLTEASGKSETVAGSEMSA 667

  Fly   706 DSGGMSCLSAVDVGP 720
            :....|...:.::.|
Mouse   668 EQQSTSSPKSTNILP 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	202/380 (53%)
Dyrk4	XP_011239406.1	PKc_DYRK4	228..568	CDD:271127	194/358 (54%)