DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk3 and Dyrk4

DIOPT Version :9

Sequence 1:	NP_001033810.1	Gene:	Dyrk3 / 3885567	FlyBaseID:	FBgn0027101	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_011239406.1	Gene:	Dyrk4 / 101320	MGIID:	1330292	Length:	685	Species:	Mus musculus

Alignment Length:	730	Identity:	272/730 - (37%)
Similarity:	385/730 - (52%)	Gaps:	132/730 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ETPATDKNNLNTTHL---ENTQLSKALSPPTSLPQIQIQMINQNLTHTGIAQNNTEKANRHQYRD 77
            :|....|.:|.|..:   ...|...::..||..|:|.: :.::.|.|.....:..:|..
Mouse    60 DTNKARKRSLTTFPILKARKKQSFTSVKGPTLPPEIYM-VESKPLGHLQKPSSKNKKLR------ 117

  Fly    78 SGLQYLTRCFEPLAMLNDSKEDFP---TQPSNNIANYPGDIQILPIFDCCEISESIQAISLPNVT 139
                 :.||.:.:    .|...||   |:...|..|:|.....:|.....:..|:  .|....::
Mouse   118 -----VNRCPQKI----PSNTAFPFVDTKGKRNTVNFPQIGNKVPSKGPMQYQEN--QIHNQVLS 171

  Fly   140 SPSKTKDVPGLFLRTISENSK---SKSEPECESLISVKESSVMENHTFLFHEQIIMSGQQKCELH 201
            |..||.::|      .:.|:|   :|..|                                 ||.
Mouse   172 SELKTSEIP------FNINTKAQDTKPHP---------------------------------ELQ 197

  Fly   202 EKPKV-LVVSPQQVMILYMNKLTPYERTEILTYPQIYFIGANAKKRPGVYGP---NNSEYDNEQG 262
            :|.|| |.|:  :.:..:.|:|:|||::|||.|.:::|:|..|||...|  |   :.:.:|:|.|
Mouse   198 KKHKVPLTVA--EALKFFKNQLSPYEQSEILGYSELWFLGLEAKKLNVV--PEKFSKTSFDDEHG 258

  Fly   263 AYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHL 327
            :|:.|.|||:|||||:|::|||||||||.|..|||.:|.|||||:||:||||.||..|::||..|
Mouse   259 SYMKVLHDHIAYRYEVLEMIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHHQALVELKILEAL 323

  Fly   328 RRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAHSLLQCLDA 392
            ||.||.|..|::||.|:|.||||.|||||||.||||||:|.|.|.||:|.:||:|..|:|:||..
Mouse   324 RRKDKDNNHNVVHMKDFFYFRNHLCITFELLGINLYELMKNNSFHGFNLSIVRRFTFSILKCLHM 388

  Fly   393 LYKNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAI 457
            ||...|||||:||||::|.|:|:..:|||||||||:|:|::||||||||||:||||||..|..||
Mouse   389 LYVEKIIHCDLKPENIVLYQRGQVTVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYNMAI 453

  Fly   458 DMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFFSPKGYPRYCTVR 522
            ||||||||:|||.:|:.|||||||.:|||||:||||:|..:...::.|.:.||..||.|:..
Mouse   454 DMWSLGCIMAELYTGYPLFPGENEVEQLACIMEVLGLPPAHFTQTASRRQVFFDSKGLPKNI--- 515

  Fly   523 TMSDGMVVLIGGQSRRGKQRGPPCSKSLSKALDGCKDPLFLNFIRGCLEWDADKRLTPSEALKHP 587
                        .:.||.:|.|. ||.|:..:. ..|..||:|:|.||.|:...|:||.:||||.
Mouse   516 ------------NNNRGGKRYPD-SKDLTMVVK-TYDSSFLDFLRRCLVWEPSLRMTPEQALKHA 566

  Fly   588 WL---RRRLPRPPSSSSGCGGVSGLCSSRNESPVTGQNRNFAAETTASSTSATSISLTIKRENSH 649
            |:   |:..|||                         ......:..||.:|..|   |.|.|...
Mouse   567 WIHEPRKFKPRP-------------------------KPQILRKPGASISSEIS---TEKAEEQQ 603

  Fly   650 SSLRLHHGAVPETDFKLIKSVPE------GSSTATKEPMMNSDILP---ESFRQTTVVSPSKHSA 705
            :|......|..||..|| |...|      |...::.|...::..||   |:..::..|:.|:.||
Mouse   604 ASKGKKDEATKETTDKL-KDEAEKHLENSGKQQSSVEHTADTIQLPHLTEASGKSETVAGSEMSA 667

  Fly   706 DSGGMSCLSAVDVGP 720
            :....|...:.::.|
Mouse   668 EQQSTSSPKSTNILP 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	202/380 (53%)
Dyrk3	NP_001033810.1	S_TKc	276..589	CDD:214567	175/312 (56%)
Dyrk4	XP_011239406.1	PKc_DYRK4	228..568	CDD:271127	194/358 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162948at33208
OrthoFinder	1	1.000	-	-		FOG0000895
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100394
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	1	1.000	-	-		X888
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.750