| Sequence 1: | NP_001033810.1 | Gene: | Dyrk3 / 3885567 | FlyBaseID: | FBgn0027101 | Length: | 828 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_005725.3 | Gene: | HIPK3 / 10114 | HGNCID: | 4915 | Length: | 1215 | Species: | Homo sapiens |
| Alignment Length: | 555 | Identity: | 166/555 - (29%) |
|---|---|---|---|
| Similarity: | 256/555 - (46%) | Gaps: | 91/555 - (16%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 192 MSGQQKCELHEKPKVLVVSPQQVMILYMNKLTPYERTEILTYPQIYFIGANAKKRPGVYGPNNSE 256
Fly 257 YDNEQGAYIHVPHD---HVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQ 318
Fly 319 EEIRILHHL--RRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRK 381
Fly 382 FAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRS--GIKVIDFGSSCFENQRI-YTYIQSRFYR 443
Fly 444 APEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKS 508
Fly 509 FFSPKGYPRYCTVRTMSDG---MVVLIGGQSRRGKQRGPPCSKSLSKALDGC-----------KD 559
Fly 560 PL--------FLNFIRGCLEWDADKRLTPSEALKHPW--LRRRLPRPPSSS-SGCGGVSGLCSSR 613
Fly 614 -NESPVTGQNRNFAAETTASSTSAT------------SISLTIKRENSHSSLRLHHGAVPETDFK 665
Fly 666 LIKSVPEGSSTATKEPMMNSDILPESFRQTTVVSP 700 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Dyrk3 | NP_001033810.1 | PKc_DYRK2_3 | 211..589 | CDD:271126 | 132/409 (32%) |
| S_TKc | 276..589 | CDD:214567 | 123/341 (36%) | ||
| HIPK3 | NP_005725.3 | STKc_HIPK3 | 196..525 | CDD:271131 | 123/340 (36%) |
| S_TKc | 197..525 | CDD:214567 | 123/339 (36%) | ||
| Interaction with AR. /evidence=ECO:0000250 | 767..944 | ||||
| Interaction with FAS. /evidence=ECO:0000250 | 796..891 | ||||
| Required for localization to nuclear speckles. /evidence=ECO:0000250 | 855..1011 | ||||
| SUMO interaction motifs (SIM), required for nuclear localization and kinase activity. /evidence=ECO:0000250 | 866..918 | ||||
| Interaction with UBL1. /evidence=ECO:0000305 | 870..880 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 912..987 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG0667 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R968 |
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 3 | 2.840 | |||||