Protein Alignment Dyrk3 and dyrk2

DIOPT Version :10

• Sequence 1: NP_001033810.1
• Gene: Dyrk3 / 3885567
• FlyBaseID: FBgn0027101
• Length: 828
• Species: Drosophila melanogaster
• Sequence 2: XP_002937581.2
• Gene: dyrk2 / 100485120
• XenbaseID: XB-GENE-854514
• Length: 625
• Species: Xenopus tropicalis
• Alignment Length: 618
• Identity: 325/618 - (52%)
• Similarity: 399/618 - (64%)
• Gaps: 93/618 - (15%)

  Fly    42 PTSLPQIQIQMINQNLTHTGIAQNNTEKANRHQYRDSGLQYLTRCFEPLAMLNDSKEDFPTQPSN 106
            |.|||.::    ..|.|||  ...|....|.|.:..|
 Frog    78 PVSLPPLR----TGNPTHT--TGGNKHTMNEHLHVTS---------------------------- 108

  Fly   107 NIANYPGDIQILPIFDCCEISESIQAISLPNVTSPSKTKDVPGLFLRTISE---------NSKSK 162
                 .|.||:..:|:  |.|.....::    |.|:....|....|..:||         ...|.
 Frog   109 -----HGQIQVQQLFE--ENSNKRTVLT----TQPNGLTTVGKSTLPVVSERQLESTHRRQGSSS 162

  Fly   163 SEPECESLISVKESSVMENHTFLFHEQIIMSGQQKCELHEKPKVLVVSPQQVMILYMNKLTPYER 227
            |....|.:..:|.||                               ::|:|.|..||.|||.:|.
 Frog   163 SLKSAEGITKLKSSS-------------------------------LTPEQAMKQYMQKLTAFEH 196

  Fly   228 TEILTYPQIYFIGANAKKRPGVY-GPNNSEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVI 291
            .||..||:|||:|.|||||.||. ||||..||::||:|:.|||||||||||:||:|||||||||:
 Frog   197 HEIFNYPEIYFLGPNAKKRQGVIGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVV 261

  Fly   292 KAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFE 356
            ||||||.|:|||||:|||||||||||.||||||.||::.||.|.||:|||.:.||||||.|:|||
 Frog   262 KAYDHKLHQHVALKMVRNEKRFHRQAAEEIRILEHLKKQDKDNNMNVIHMLENFTFRNHICMTFE 326

  Fly   357 LLSINLYELIKKNGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRSGIKVI 421
            |||:|||||||||.|:||||.||||||||:|||||||:||.|||||:||||:|||||||||||||
 Frog   327 LLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVI 391

  Fly   422 DFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLA 486
            ||||||:|:||:||||||||||||||||||:||..||||||||||||||:|:.|.|||:|.||||
 Frog   392 DFGSSCYEHQRVYTYIQSRFYRAPEVILGGRYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLA 456

  Fly   487 CIIEVLGMPNKNILASSKRSKSFFSPKGYPRYCTVRTMSDGMVVLIGGQSRRGKQRGPPCSKSLS 551
            |:||:||||::.:|.:|||.|:|||.|||||||||.::.||.|||.||:|||||.||||.|:...
 Frog   457 CMIELLGMPSQKLLDASKRGKNFFSSKGYPRYCTVTSLPDGSVVLNGGRSRRGKLRGPPGSRDWV 521

  Fly   552 KALDGCKDPLFLNFIRGCLEWDADKRLTPSEALKHPWLRRRLPRPPS----SSSGCGGVSGLCSS 612
            .||.||.|||||:|:..|||||...|:|||:||:|.|||||||:||:    |:......:|..:|
 Frog   522 TALKGCDDPLFLDFLTQCLEWDPSLRMTPSQALRHHWLRRRLPKPPTGEKISTKRITESTGAITS 586

  Fly   613 RNESPVTGQNRNFAAETTASSTSATSISLTIKR 645
            .::.|.|..:   ||:...:.|..|..:..|::
 Frog   587 ISKLPPTSGS---AAKLRTNLTQITDANGNIQQ 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	276/378 (73%)
dyrk2	XP_002937581.2	PKc_DYRK2_3	180..559	CDD:271126	276/378 (73%)