Protein Alignment Dyrk3 and dyrk1aa

DIOPT Version :10

• Sequence 1: NP_001033810.1
• Gene: Dyrk3 / 3885567
• FlyBaseID: FBgn0027101
• Length: 828
• Species: Drosophila melanogaster
• Sequence 2: NP_001074158.1
• Gene: dyrk1aa / 100005019
• ZFINID: ZDB-GENE-050302-29
• Length: 737
• Species: Danio rerio
• Alignment Length: 716
• Identity: 224/716 - (31%)
• Similarity: 332/716 - (46%)
• Gaps: 139/716 - (19%)

  Fly   174 KESSVMENHTFLFHEQIIMSGQQKCELH-------------EKPKVLVVSPQ-------QV---M 215
            |.|||....:|.||...:....|....|             :....|..:||       ||   |
Zfish    15 KPSSVRLAPSFSFHSAGVQMDAQTPHSHPPFSDAHPQGAADQSAAALPYNPQAPQPSATQVTADM 79

  Fly   216 ILYMNKL---------TPYERTE---ILTYP---QIYFI-------------GANAKKRPGVYGP 252
            ::...::         .|..:..   |.||.   ::|:.             .:|.|:|. :|
Zfish    80 VMLQRRMPQCFRDPATAPLRKLSIELIKTYKHINEVYYAKKKRRHQQGQGEDSSNKKERK-IY-- 141

  Fly   253 NNSEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQA 317
             |..||::...||....:....|||:..:|||||||||:||||....|.||:||::|:|.|..||
Zfish   142 -NDGYDDDNFDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQA 205

  Fly   318 QEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKF 382
            |.|:|:|..:.:||......|:|:..:|.||||.|:.||:||.|||:|::...|:|.||.|.|||
Zfish   206 QIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKF 270

  Fly   383 AHSLLQCLDALY----KNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYR 443
            |..|  |...|:    :..|||||:||||:||....||.||::||||||...||||.||||||||
Zfish   271 AQQL--CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYR 333

  Fly   444 APEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKS 508
            :|||:||..|..|||||||||||.|:.:|..||.|.||.||:..|:||||:|..:||..:.:::.
Zfish   334 SPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGVPPSHILEQAPKARK 398

  Fly   509 FFSPKGYPRYCTVRTMSDGMVVLIGGQSRR-----GKQRGPPCSKSLSKALDGCKDPL-FLNFIR 567
            ||.......:|..:| .||......| ||:     |.:.|.|..:...::.....|.| |.:.|.
Zfish   399 FFEKMPDSMWCAKKT-KDGKRYKPAG-SRKLHSILGVEAGGPGGRRAGESGHAVADYLKFKDLIL 461

  Fly   568 GCLEWDADKRLTPSEALKHPWLRRRLPRPPSSSSGCGGVSGLCSSRNESPVTGQNRNFAAETTAS 632
            ..|::|...|:.|..||:|.:.::......::|          ||.:.||...|:::....::.|
Zfish   462 RMLDYDPKTRIQPYYALQHSFFKKTADEGTNTS----------SSVSTSPALEQSQSSGTTSSTS 516

  Fly   633 S----TSATSISLTIKRENSHSSLRLH--------------HGAVPETDFKLIKS---VPEGSST 676
            |    :|.||.|...:.:.:|.  ..|              |...|:.....:.:   |.:|...
Zfish   517 SSSGGSSGTSTSGRARSDPTHQ--HRHSGGGHFSAAVAMDCHNLCPQARQAFVPALGWVGDGLQQ 579

  Fly   677 ATKE--PMMNSDI-LPESFRQTTVVSPSK------HSADSGGMSCLSAVDVGPSRYYPYMNNNEN 732
            |:.|  |:..:.. :|.  .|...:.|.:      |.....|.        ||:|..|.:.:..:
Zfish   580 ASGETHPVQETTFHVPP--HQPKALHPHQHHHHHHHHPPPHGQ--------GPARPRPRLYSPSH 634

  Fly   733 N------------RLFSSSLNSSANSLSHLEQATKLDALGEYSASTTPNLLSKNTGYSFNSGSIN 785
            :            .|..:||:|||:|.|     |...:.|.:..:.....|....|:. :|||:.
Zfish   635 SASTQDSMEVTHGHLSMTSLSSSASSSS-----TSSSSTGNHHYAYQSRPLPHGLGFG-HSGSMT 693

  Fly   786 I 786
            :
Zfish   694 L 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	169/425 (40%)
dyrk1aa	NP_001074158.1	PKc_DYRK1	151..488	CDD:271128	152/340 (45%)