DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dyrk3 and dyrk1aa

DIOPT Version :9

Sequence 1:	NP_001033810.1	Gene:	Dyrk3 / 3885567	FlyBaseID:	FBgn0027101	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001074158.1	Gene:	dyrk1aa / 100005019	ZFINID:	ZDB-GENE-050302-29	Length:	737	Species:	Danio rerio

Alignment Length:	716	Identity:	224/716 - (31%)
Similarity:	332/716 - (46%)	Gaps:	139/716 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 KESSVMENHTFLFHEQIIMSGQQKCELH-------------EKPKVLVVSPQ-------QV---M 215
            |.|||....:|.||...:....|....|             :....|..:||       ||   |
Zfish    15 KPSSVRLAPSFSFHSAGVQMDAQTPHSHPPFSDAHPQGAADQSAAALPYNPQAPQPSATQVTADM 79

  Fly   216 ILYMNKL---------TPYERTE---ILTYP---QIYFI-------------GANAKKRPGVYGP 252
            ::...::         .|..:..   |.||.   ::|:.             .:|.|:|. :|
Zfish    80 VMLQRRMPQCFRDPATAPLRKLSIELIKTYKHINEVYYAKKKRRHQQGQGEDSSNKKERK-IY-- 141

  Fly   253 NNSEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQA 317
             |..||::...||....:....|||:..:|||||||||:||||....|.||:||::|:|.|..||
Zfish   142 -NDGYDDDNFDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQA 205

  Fly   318 QEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKF 382
            |.|:|:|..:.:||......|:|:..:|.||||.|:.||:||.|||:|::...|:|.||.|.|||
Zfish   206 QIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKF 270

  Fly   383 AHSLLQCLDALY----KNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYR 443
            |..|  |...|:    :..|||||:||||:||....||.||::||||||...||||.||||||||
Zfish   271 AQQL--CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYR 333

  Fly   444 APEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKS 508
            :|||:||..|..|||||||||||.|:.:|..||.|.||.||:..|:||||:|..:||..:.:::.
Zfish   334 SPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGVPPSHILEQAPKARK 398

  Fly   509 FFSPKGYPRYCTVRTMSDGMVVLIGGQSRR-----GKQRGPPCSKSLSKALDGCKDPL-FLNFIR 567
            ||.......:|..:| .||......| ||:     |.:.|.|..:...::.....|.| |.:.|.
Zfish   399 FFEKMPDSMWCAKKT-KDGKRYKPAG-SRKLHSILGVEAGGPGGRRAGESGHAVADYLKFKDLIL 461

  Fly   568 GCLEWDADKRLTPSEALKHPWLRRRLPRPPSSSSGCGGVSGLCSSRNESPVTGQNRNFAAETTAS 632
            ..|::|...|:.|..||:|.:.::......::|          ||.:.||...|:::....::.|
Zfish   462 RMLDYDPKTRIQPYYALQHSFFKKTADEGTNTS----------SSVSTSPALEQSQSSGTTSSTS 516

  Fly   633 S----TSATSISLTIKRENSHSSLRLH--------------HGAVPETDFKLIKS---VPEGSST 676
            |    :|.||.|...:.:.:|.  ..|              |...|:.....:.:   |.:|...
Zfish   517 SSSGGSSGTSTSGRARSDPTHQ--HRHSGGGHFSAAVAMDCHNLCPQARQAFVPALGWVGDGLQQ 579

  Fly   677 ATKE--PMMNSDI-LPESFRQTTVVSPSK------HSADSGGMSCLSAVDVGPSRYYPYMNNNEN 732
            |:.|  |:..:.. :|.  .|...:.|.:      |.....|.        ||:|..|.:.:..:
Zfish   580 ASGETHPVQETTFHVPP--HQPKALHPHQHHHHHHHHPPPHGQ--------GPARPRPRLYSPSH 634

  Fly   733 N------------RLFSSSLNSSANSLSHLEQATKLDALGEYSASTTPNLLSKNTGYSFNSGSIN 785
            :            .|..:||:|||:|.|     |...:.|.:..:.....|....|:. :|||:.
Zfish   635 SASTQDSMEVTHGHLSMTSLSSSASSSS-----TSSSSTGNHHYAYQSRPLPHGLGFG-HSGSMT 693

  Fly   786 I 786
            :
Zfish   694 L 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	169/425 (40%)
Dyrk3	NP_001033810.1	S_TKc	276..589	CDD:214567	149/322 (46%)
dyrk1aa	NP_001074158.1	PKc_DYRK1	151..488	CDD:271128	152/340 (45%)
dyrk1aa	NP_001074158.1	S_TKc	164..483	CDD:214567	149/322 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840