DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIP4K and Pip4k2b

DIOPT Version :9

Sequence 1:	NP_001033805.1	Gene:	PIP4K / 3885565	FlyBaseID:	FBgn0039924	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_446002.1	Gene:	Pip4k2b / 89812	RGDID:	621710	Length:	416	Species:	Rattus norvegicus

Alignment Length:	403	Identity:	232/403 - (57%)
Similarity:	297/403 - (73%)	Gaps:	25/403 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KKKHFRVKHQKVKLFRANEPILSVFMWGINHTINELSHVNIPVMLLPDDFRAYSKIKVDNHLFNK 79
            |||||..  ||||||||:||||||.|||:||||||||:|.:||||:||||:||||||||||||||
  Rat    24 KKKHFVC--QKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNK 86

  Fly    80 ENMPSHFKVKEYCPLVFRNLRERFGVDDVDYRESLTRSQPIQIDSSGKSGAQFYQSYDKFFIIKS 144
            ||:||.||.|||||:||||||||||:||.||:.|:|||.||..||.|:.|.:|..:||:.|:||:
  Rat    87 ENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKT 151

  Fly   145 LTSEEIERMHAFLKQYHPYVVERHGKTLLPQYLGMYRITVESVQYYFVVMRNVFSSHLTIHKKFD 209
            ::||::..||..||:||.::||.||.|||||:|||||:||:.|:.|.||.|||||..||:|:|:|
  Rat   152 VSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYD 216

  Fly   210 LKGSTVDREASEKELEKNLPTFKDNDFIKQKVKLDIGKEAKDKLMDTLSNDVDLLTKLHIMDYSL 274
            ||||||.||||:||..|:|||||||||:.:..||.:|:|:|...::.|..||:.|.:|.||||||
  Rat   217 LKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLRVGEESKKNFLEKLKRDVEFLAQLKIMDYSL 281

  Fly   275 LVGVHDCVRAEEEALQGDNILTVGRSENSESEECDS-----GERWTYNTPPDS-------PRGAQ 327
            |||:||..|||:|..:.:        :.:|.|||::     |...:|.|||||       ||...
  Rat   282 LVGIHDVDRAEQEETEVE--------DRAEEEECENDGVGGGLLCSYGTPPDSPGNLLSFPRFFG 338

  Fly   328 YKEVVYEVDIYDIPSIEE--KREIYFIAIIDVLTQYGVKKQAAKAAKTVKYGSNVDGISTCDPEQ 390
            ..|....||:|.:.|.|.  |:|:||:||||:||.|..||:||.||||||:|:..: |||.:|||
  Rat   339 PGEFDPSVDVYAMKSHESAPKKEVYFMAIIDILTPYDAKKKAAHAAKTVKHGAGAE-ISTVNPEQ 402

  Fly   391 YAKRFLDFMDKAI 403
            |:|||.:||...:
  Rat   403 YSKRFNEFMSNIL 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIP4K	NP_001033805.1	PIPKc	32..403	CDD:295374	219/384 (57%)
Pip4k2b	NP_446002.1	PIPKc	39..416	CDD:238081	219/386 (57%)
Pip4k2b	NP_446002.1	Required for interaction with PIP5K1A. /evidence=ECO:0000250\|UniProtKB:Q8TBX8	64..70		4/5 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	281	1.000	Domainoid score	I1597
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2634
Inparanoid	1	1.050	455	1.000	Inparanoid score	I1537
OMA	1	1.010	-	-		QHG52363
OrthoDB	1	1.010	-	-		D1562683at2759
OrthoFinder	1	1.000	-	-		FOG0001219
OrthoInspector	1	1.000	-	-		otm45659
orthoMCL	1	0.900	-	-		OOG6_104901
Panther	1	1.100	-	-	LDO	PTHR23086
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X950
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840