DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PIP4K and PIP4K2B

DIOPT Version :9

Sequence 1:	NP_001033805.1	Gene:	PIP4K / 3885565	FlyBaseID:	FBgn0039924	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	XP_011523628.1	Gene:	PIP4K2B / 8396	HGNCID:	8998	Length:	443	Species:	Homo sapiens

Alignment Length:	430	Identity:	232/430 - (53%)
Similarity:	297/430 - (69%)	Gaps:	52/430 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KKKHFRVKHQKVKLFRANEPILSVFMWGINHTINELSHVNIPVMLLPDDFRAYSKIKVDNHLFNK 79
            |||||..  ||||||||:||||||.|||:||||||||:|.:||||:||||:||||||||||||||
Human    24 KKKHFVC--QKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNK 86

  Fly    80 ENMPSHFKVKEYCPLVFRNLRERFGVDDVDYRESLTRSQPIQIDSSGKSGAQFYQSYDKFFIIKS 144
            ||:||.||.|||||:||||||||||:||.||:.|:|||.||..||.|:.|.:|..:||:.|:||:
Human    87 ENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKT 151

  Fly   145 LTSEEIERMHAFLKQYH---------------------------PYVVERHGKTLLPQYLGMYRI 182
            ::||::..||..||:||                           .::||.||.|||||:|||||:
Human   152 VSSEDVAEMHNILKKYHQMAGSLACLCILSLPCGIPISGWQKRCKFIVECHGNTLLPQFLGMYRL 216

  Fly   183 TVESVQYYFVVMRNVFSSHLTIHKKFDLKGSTVDREASEKELEKNLPTFKDNDFIKQKVKLDIGK 247
            ||:.|:.|.||.|||||..||:|:|:|||||||.||||:||..|:|||||||||:.:..||.:|:
Human   217 TVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGE 281

  Fly   248 EAKDKLMDTLSNDVDLLTKLHIMDYSLLVGVHDCVRAEEEALQGDNILTVGRSENSESEECDS-- 310
            |:|...::.|..||:.|.:|.|||||||||:||..|||:|.::.:        |.:|.|||::
Human   282 ESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVE--------ERAEDEECENDG 338

  Fly   311 ---GERWTYNTPPDS-------PRGAQYKEVVYEVDIYDIPSIEE--KREIYFIAIIDVLTQYGV 363
               ....:|.|||||       ||.....|....||:|.:.|.|.  |:|:||:||||:||.|..
Human   339 VGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDT 403

  Fly   364 KKQAAKAAKTVKYGSNVDGISTCDPEQYAKRFLDFMDKAI 403
            ||:||.||||||:|:..: |||.:||||:|||.:||...:
Human   404 KKKAAHAAKTVKHGAGAE-ISTVNPEQYSKRFNEFMSNIL 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIP4K	NP_001033805.1	PIPKc	32..403	CDD:295374	219/411 (53%)
PIP4K2B	XP_011523628.1	PIPKc	39..443	CDD:238081	219/413 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	281	1.000	Domainoid score	I1678
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2634
Inparanoid	1	1.050	455	1.000	Inparanoid score	I1592
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52363
OrthoDB	1	1.010	-	-		D1562683at2759
OrthoFinder	1	1.000	-	-		FOG0001219
OrthoInspector	1	1.000	-	-		otm41537
orthoMCL	1	0.900	-	-		OOG6_104901
Panther	1	1.100	-	-	LDO	PTHR23086
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2198
SonicParanoid	1	1.000	-	-		X950
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.910