DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIP4K and pip4k2ab

DIOPT Version :9

Sequence 1:	NP_001033805.1	Gene:	PIP4K / 3885565	FlyBaseID:	FBgn0039924	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	XP_005163424.1	Gene:	pip4k2ab / 555920	ZFINID:	ZDB-GENE-070912-272	Length:	445	Species:	Danio rerio

Alignment Length:	436	Identity:	222/436 - (50%)
Similarity:	284/436 - (65%)	Gaps:	69/436 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KKKHFRVKHQKVKLFRANEPILSVFMWGINHTINELSHVNIPVMLLPDDFRAYSKIKVDNHLFNK 79
            ||:||  ..||||||||::|:|||.|||:||:||||.|:.|||||:||||:|.||||||||||||
Zfish    23 KKQHF--VSQKVKLFRASDPLLSVLMWGVNHSINELRHIQIPVMLMPDDFKANSKIKVDNHLFNK 85

  Fly    80 ENMPSHFKVKEYCPLVFRNLRERFGVDDVDYRESLTRSQPIQIDSSGKSGAQFYQSYDKFFIIKS 144
            ||||||||.|||||||||||||||.:||.:|:.||||..||..|:.|:|||:|:.|::|.::||.
Zfish    86 ENMPSHFKFKEYCPLVFRNLRERFSIDDQEYQNSLTRRAPIPSDAQGRSGARFHTSHNKRYVIKI 150

  Fly   145 LTSEEIERMHAFLKQYHPYVVERHGKTLLPQYLGMYRITVESVQYYFVVMRNVFSSHLTIHKKFD 209
            :|||::..||..||:||.|:||.||.|||||:|||||:||:..:.|.:|.|||||..|.::||:|
Zfish   151 ITSEDVAEMHNILKKYHQYIVECHGNTLLPQFLGMYRLTVDGDETYMIVTRNVFSHRLPVYKKYD 215

  Fly   210 LKGSTVDREASEKEL--------------------------------EKNLPTFKDNDFIKQKVK 242
            ||||||.||||:||.                                .|.|||:||||||....|
Zfish   216 LKGSTVAREASDKEKPRPPEEAPSKSRMSQKLQTIRIATRFYCAIRHTKELPTYKDNDFINDGQK 280

  Fly   243 LDIGKEAKDKLMDTLSNDVDLLTKLHIMDYSLLVGVHDCVRAEEEALQGDNILTVGRSENSESEE 307
            :.|..|.|...::.|.|||:.|.:|.:||||||||:||..|.|:|            ....|||:
Zfish   281 ICIDDENKKMFLEKLKNDVEFLAQLKLMDYSLLVGIHDVERGEQE------------QPEEESED 333

  Fly   308 CDSGER-------WTYNTPPDSPRG----------AQYKEVVYEVDIYDIPSIEE--KREIYFIA 353
            .|:||.       ....:|||||..          .::..:   :|:|.|.|.|.  |:||||:|
Zfish   334 NDAGEEEGTESDGGATGSPPDSPSNTLDSNRPLGPGEFDPI---IDVYAIKSHENAPKKEIYFMA 395

  Fly   354 IIDVLTQYGVKKQAAKAAKTVKYGSNVDGISTCDPEQYAKRFLDFM 399
            :||:||.|..||:||.||||||:|:..: |||.:||||:|||.||:
Zfish   396 VIDILTPYDAKKKAAHAAKTVKHGAGAE-ISTVNPEQYSKRFYDFI 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIP4K	NP_001033805.1	PIPKc	32..403	CDD:295374	210/419 (50%)
pip4k2ab	XP_005163424.1	PIPKc	66..444	CDD:214623	191/391 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595451
Domainoid	1	1.000	262	1.000	Domainoid score	I1902
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2634
Inparanoid	1	1.050	431	1.000	Inparanoid score	I1688
OMA	1	1.010	-	-		QHG52363
OrthoDB	1	1.010	-	-		D1562683at2759
OrthoFinder	1	1.000	-	-		FOG0001219
OrthoInspector	1	1.000	-	-		otm25941
orthoMCL	1	0.900	-	-		OOG6_104901
Panther	1	1.100	-	-	O	PTHR23086
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2198
SonicParanoid	1	1.000	-	-		X950
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940