DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIP4K and PIP4K2A

DIOPT Version :9

Sequence 1:	NP_001033805.1	Gene:	PIP4K / 3885565	FlyBaseID:	FBgn0039924	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_005019.2	Gene:	PIP4K2A / 5305	HGNCID:	8997	Length:	406	Species:	Homo sapiens

Alignment Length:	394	Identity:	227/394 - (57%)
Similarity:	287/394 - (72%)	Gaps:	20/394 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KKKHFRVKHQKVKLFRANEPILSVFMWGINHTINELSHVNIPVMLLPDDFRAYSKIKVDNHLFNK 79
            |||||..  ||||||||::|:|||.|||:||:|||||||.|||||:||||:||||||||||||||
Human    19 KKKHFVA--QKVKLFRASDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNK 81

  Fly    80 ENMPSHFKVKEYCPLVFRNLRERFGVDDVDYRESLTRSQPIQIDSSGKSGAQFYQSYDKFFIIKS 144
            ||||||||.|||||:||||||||||:||.|::.|||||.|:..||..:|||:|:.||||.:|||:
Human    82 ENMPSHFKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYIIKT 146

  Fly   145 LTSEEIERMHAFLKQYHPYVVERHGKTLLPQYLGMYRITVESVQYYFVVMRNVFSSHLTIHKKFD 209
            :|||::..||..||:||.|:||.||.|||||:|||||:.|:.|:.|.:|.|||||..|::::|:|
Human   147 ITSEDVAEMHNILKKYHQYIVECHGITLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSVYRKYD 211

  Fly   210 LKGSTVDREASEKELEKNLPTFKDNDFIKQKVKLDIGKEAKDKLMDTLSNDVDLLTKLHIMDYSL 274
            ||||||.||||:||..|.|||.||||||.:..|:.|....|...::.|..||:.|.:|.:|||||
Human   212 LKGSTVAREASDKEKAKELPTLKDNDFINEGQKIYIDDNNKKVFLEKLKKDVEFLAQLKLMDYSL 276

  Fly   275 LVGVHDCVRAEEEALQGDNILTVGRSENSESEECDSGERWTYNTPPDSPRGAQYK-------EVV 332
            |||:||..|||:|.::.:        ||...||.:|.......||||||......       |..
Human   277 LVGIHDVERAEQEEVECE--------ENDGEEEGESDGTHPVGTPPDSPGNTLNSSPPLAPGEFD 333

  Fly   333 YEVDIYDIPSIEE--KREIYFIAIIDVLTQYGVKKQAAKAAKTVKYGSNVDGISTCDPEQYAKRF 395
            ..:|:|.|...|.  ::|:||:||||:||.|..||:||.||||||:|:..: |||.:||||:|||
Human   334 PNIDVYGIKCHENSPRKEVYFMAIIDILTHYDAKKKAAHAAKTVKHGAGAE-ISTVNPEQYSKRF 397

  Fly   396 LDFM 399
            |||:
Human   398 LDFI 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIP4K	NP_001033805.1	PIPKc	32..403	CDD:295374	214/377 (57%)
PIP4K2A	NP_005019.2	PIPKc_PIP5K2A	27..403	CDD:340446	221/384 (58%)
		Required for interaction with PIP5K1A. /evidence=ECO:0000250\|UniProtKB:Q8TBX8	59..65		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	288..329		12/48 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159315
Domainoid	1	1.000	281	1.000	Domainoid score	I1678
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	455	1.000	Inparanoid score	I1592
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52363
OrthoDB	1	1.010	-	-		D1562683at2759
OrthoFinder	1	1.000	-	-		FOG0001219
OrthoInspector	1	1.000	-	-		otm41537
orthoMCL	1	0.900	-	-		OOG6_104901
Panther	1	1.100	-	-	O	PTHR23086
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2198
SonicParanoid	1	1.000	-	-		X950
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800