DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PIP4K and pip5k1ab

DIOPT Version :9

Sequence 1:	NP_001033805.1	Gene:	PIP4K / 3885565	FlyBaseID:	FBgn0039924	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	XP_021322354.1	Gene:	pip5k1ab / 492549	ZFINID:	ZDB-GENE-041111-123	Length:	598	Species:	Danio rerio

Alignment Length:	372	Identity:	121/372 - (32%)
Similarity:	188/372 - (50%)	Gaps:	26/372 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 GINHTINELSHVNIPVMLLPDDFRAYSKIKVDNHLFNKEN---MPSH----FKVKEYCPLVFRNL 99
            ||.||:..||......:|:.|.:      .|::..|..|.   .|:|    |:.|.|.|:.||..
Zfish    81 GIAHTVGSLSQKAERDVLMQDFY------VVESIFFPSEGSNLTPAHHHGDFRFKTYAPIAFRYF 139

  Fly   100 RERFGVDDVDYRESLTRSQPIQIDSSGKSGAQFYQSYDKFFIIKSLTSEEIERMHAFLKQYHPYV 164
            ||.||:...||..||.....|::.:.|.||:.||.:.|..||||::..:|.|.:...|..|. ..
Zfish   140 RELFGIRPDDYLYSLCNDPLIELSNPGASGSIFYVTSDDEFIIKTVMHKEAEFLQKLLPGYF-MN 203

  Fly   165 VERHGKTLLPQYLGMYRITVESVQYYFVVMRNVFSSHLTIHKKFDLKGSTVDREASEKELEKNLP 229
            :.::.:||||::.|:|.:.........|||.|:....:.:|.|:||||||..|.||.||.:|::|
Zfish   204 LNQNKRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVPMHLKYDLKGSTYKRRASPKERDKSVP 268

  Fly   230 TFKDNDFIKQKVK-LDIGKEAKDKLMDTLSNDVDLLTKLHIMDYSLLVGVHDCVRAEEEALQGDN 293
            |:||.|||:...: :.:..:..:.|..|:..|..||....|||||||||||:...|..|..   .
Zfish   269 TYKDLDFIQDMPEGIQLEPDNYNALCKTIQRDCLLLQSFKIMDYSLLVGVHNTDLASRERA---G 330

  Fly   294 ILTVGRSENSESEE--CDSGERWTYNTPPDSPRG-AQYKEVVYEVDIY-DIPSIEEKRE--IYFI 352
            ::..|.||.:.:.:  ....::..|:|..:|.:| |:.|..:...|.: .||:...:.|  :.:|
Zfish   331 VVEGGGSEGTVTPDHRRPQIQKALYSTAMESIQGEAKGKGTLETEDQWGGIPARNSRGERILVYI 395

  Fly   353 AIIDVLTQYGVKKQAAKAAKTVKYGSNVDGISTCDPEQYAKRFLDFM 399
            .|||:|..|...|:...:.|.:.:..  |.:|...|..||:||..||
Zfish   396 GIIDILQSYRFIKKLEHSWKALVHDG--DTVSVHRPGFYAERFQRFM 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIP4K	NP_001033805.1	PIPKc	32..403	CDD:295374	121/372 (33%)
pip5k1ab	XP_021322354.1	PIPKc	98..444	CDD:214623	115/355 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52363
OrthoDB	1	1.010	-	-		D1562683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.830