DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PIP4K and PIP5K59B

DIOPT Version :9

Sequence 1:	NP_001033805.1	Gene:	PIP4K / 3885565	FlyBaseID:	FBgn0039924	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_001369113.1	Gene:	PIP5K59B / 37633	FlyBaseID:	FBgn0034789	Length:	891	Species:	Drosophila melanogaster

Alignment Length:	457	Identity:	131/457 - (28%)
Similarity:	211/457 - (46%)	Gaps:	95/457 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SSSSQPRILKKKHFRV------KHQKVKLFRANEPILSVFMWGINHTINELSHVNIPVMLLPDDF 64
            :||...:..|..|.||      .::|::    ...|:.....||.||:..|:......:|:.|.:
  Fly    49 ASSKADKERKIGHRRVGEGGEITYKKIQ----TSQIMGSIQLGIQHTVGSLASKPKRDLLMMDFW 109

  Fly    65 RAYSKIKVDNHLFNKEN---MPSH----FKVKEYCPLVFRNLRERFGVDDVDYRESLTRSQPIQI 122
                  ::::..|..|.   .|:|    |:.|.|.|:.||..|:.||:...|:..|:..|...::
  Fly   110 ------EIESITFPPEGSSLTPAHHYSEFRYKIYAPIAFRYFRDLFGIQPDDFMMSMCTSPLREL 168

  Fly   123 DSSGKSGAQFYQSYDKFFIIKSLTSEEIERMHAFLKQYHPYVVERHGKTLLPQYLGMYRI-TVES 186
            .:.|.||:.||.:.|..||||::..:|.|.:...|..|: ..:.::.:||||::.|:|.: |..:
  Fly   169 SNPGASGSIFYLTTDDEFIIKTVQHKEGEFLQKLLPGYY-MNLNQNPRTLLPKFFGLYCLQTSNA 232

  Fly   187 VQYYFVVMRNVFSSHLTIHKKFDLKGSTVDREASEKELEKNLPTFKDNDFIKQKVK-LDIGKEAK 250
            .....|||.|:..|.:.:|.|:||||||..|:|::.|..|..||:||.||::|... :.:..|..
  Fly   233 KNIRLVVMNNLLPSSVKMHLKYDLKGSTFKRKANKAERAKKSPTYKDLDFMEQHPNGIFLEAETY 297

  Fly   251 DKLMDTLSNDVDLLTKLHIMDYSLLVGVHDC--------------VRA---------EEEALQGD 292
            ..|:.|:..|..:|....|||||||:|||:.              :||         .::.|.||
  Fly   298 AALIKTIQRDCTVLESFKIMDYSLLLGVHNLDVALKEKQSEQRKPLRAPLAEDSDVDADDPLDGD 362

  Fly   293 NILTVGRSEN-----------------SESEECDSGERWTYNTPPDSPRGAQYKEVVYEVDIYDI 340
            ....:.|:::                 :|||..|..|        |.|.|.             |
  Fly   363 AATGISRNKSVNRQRLVAHSTAMESIQAESEPIDDEE--------DVPPGG-------------I 406

  Fly   341 PSIEEKRE--IYFIAIIDVLTQYGVKKQAAKAAKTVKYGSNVDG--ISTCDPEQYAKRFLDFMDK 401
            |:..||.|  :.:|.|||:|..|.:||:.....|::.:    ||  :|.|.|..||:||.:||.|
  Fly   407 PARSEKGERLLLYIGIIDILQSYRLKKKLEHTFKSIIH----DGETVSVCRPSFYAQRFQNFMAK 467

  Fly   402 AI 403
            .:
  Fly   468 TV 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIP4K	NP_001033805.1	PIPKc	32..403	CDD:295374	124/423 (29%)
PIP5K59B	NP_001369113.1	PIPKc_PIP5KI	78..473	CDD:340438	124/424 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457237
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5253
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1562683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23086
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2198
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.880