DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PIP4K and pip4k2ca

DIOPT Version :9

Sequence 1:	NP_001033805.1	Gene:	PIP4K / 3885565	FlyBaseID:	FBgn0039924	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_956395.2	Gene:	pip4k2ca / 373124	ZFINID:	ZDB-GENE-030828-9	Length:	416	Species:	Danio rerio

Alignment Length:	423	Identity:	212/423 - (50%)
Similarity:	283/423 - (66%)	Gaps:	50/423 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SSSQPRIL-------KKKHFRVKHQKVKLFRANEPILSVFMWGINHTINELSHVNIPVMLLPDDF 64
            |:|.|.::       ||:||  ..||||:|||::|:|||||||:||:||:|:.|.:|||||||||
Zfish     9 SASSPMVMLAPKTKTKKRHF--MQQKVKVFRASDPMLSVFMWGVNHSINDLNQVPVPVMLLPDDF 71

  Fly    65 RAYSKIKVDNHLFNKENMPSHFKVKEYCPLVFRNLRERFGVDDVDYRESLTRSQPIQIDSSGKSG 129
            :|.:||||:||||||||:||||:.|||||.||||||||||::|:||:.||.||.|::.|..|:
Zfish    72 KANTKIKVNNHLFNKENLPSHFEFKEYCPQVFRNLRERFGIEDLDYQASLARSAPMKGDGQGE-- 134

  Fly   130 AQFYQSYDKFFIIKSLTSEEIERMHAFLKQYHPYVVERHGKTLLPQYLGMYRITVESVQYYFVVM 194
            ...:.|||:..|:|.::|||:..||..|.:||.::|:.||.|||||:||||||||||...|.:||
Zfish   135 GLLFTSYDRTLIVKQISSEEVADMHNILSEYHQHIVKCHGSTLLPQFLGMYRITVESEDTYLIVM 199

  Fly   195 RNVFSSHLTIHKKFDLKGSTVDREASEKELEKNLPTFKDNDFIKQKVKLDIGKEAKDKLMDTLSN 259
            ||:||..|.:|:|:|||||.||||||:||..|.||||||.||.....|:.:.:|.|:|:|:.|:.
Zfish   200 RNMFSHRLLVHRKYDLKGSLVDREASDKEKVKELPTFKDMDFRNNMQKVYVTEEQKEKMMEKLNR 264

  Fly   260 DVDLLTKLHIMDYSLLVGVHDCVRAEEEALQGDNILTVGRSENSESEEC-------DSG-----E 312
            ||:.|.||.|||||||:|:||..|.|             |.|....|.|       ::|     :
Zfish   265 DVEFLVKLKIMDYSLLLGIHDVARGE-------------REEEEAEEPCYEDDADPENGLAPALQ 316

  Fly   313 RWTYNTPPDSPRGAQYKEVVYE---------VDIYDIPSI--EEKREIYFIAIIDVLTQYGVKKQ 366
            ..:|.|.|:...|  |...:..         :|:|.:.|.  ..:||:||:.:|||||||..||:
Zfish   317 VGSYGTSPEGIAG--YMNSIKPLGPGEFDPYIDVYAVKSAPGAPQREVYFMGLIDVLTQYDTKKK 379

  Fly   367 AAKAAKTVKYGSNVDGISTCDPEQYAKRFLDFM 399
            ||.||||||:|:..: |||..||||||||.:|:
Zfish   380 AAHAAKTVKHGAGAE-ISTVHPEQYAKRFREFI 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIP4K	NP_001033805.1	PIPKc	32..403	CDD:295374	198/391 (51%)
pip4k2ca	NP_956395.2	PIPKc	67..415	CDD:214623	180/363 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1902
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	431	1.000	Inparanoid score	I1688
OMA	1	1.010	-	-		QHG52363
OrthoDB	1	1.010	-	-		D1562683at2759
OrthoFinder	1	1.000	-	-		FOG0001219
OrthoInspector	1	1.000	-	-		otm25941
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23086
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X950
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	11.080