DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PIP4K and pikfyve

DIOPT Version :9

Sequence 1:	NP_001033805.1	Gene:	PIP4K / 3885565	FlyBaseID:	FBgn0039924	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	XP_009302996.1	Gene:	pikfyve / 337690	ZFINID:	ZDB-GENE-030131-9636	Length:	2121	Species:	Danio rerio

Alignment Length:	394	Identity:	91/394 - (23%)
Similarity:	142/394 - (36%)	Gaps:	122/394 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 NHTINELSHVNIPVMLL--PDDFRAYSKIKVDNHLFNKENMPSHFKVKEYCPLV----FRNLRER 102
            ::::::||..::....|  |:......|...:.|:   |...|....|.||.:.    |..:||.
Zfish  1798 DNSMSQLSRSSVDADPLKEPESADKQKKQTGNPHI---ELQFSDANAKFYCRIYYAEEFHKMREE 1859

  Fly   103 F--GVDDVDYRESLTRSQPIQIDSSGKSGAQFYQSYDKFFIIKSLTSEEIERMHAFLKQYHPYV- 164
            .  ..:| |:..||:.....|. ..|||||.||.:.|..||:|.:...|::....|...|..|:
Zfish  1860 IMESTED-DFVRSLSHCVNWQA-RGGKSGAVFYATEDDRFILKQMPRLEVQSFLDFAPHYFTYIT 1922

  Fly   165 --VERHGKTLLPQYLGMYRITVESVQ------YYFVVMRNVFSSHLTIHKKFDLKGSTVDREASE 221
              |.....|.|.:.||:|||..::.|      ...:||.|:|... .:.:.||||||..:|
Zfish  1923 GAVHLKRPTALAKILGVYRIGYKNSQNNTEKKLDLLVMENLFYGR-KMAQVFDLKGSLRNR---- 1982

  Fly   222 KELEKNLPTFKDNDFIKQKVKLDIGKEAKDKLMDTLSNDVDLLTKLHIMDYSLLVGVHDCVRAEE 286
                              .||.|.|||:    .:.:..|.:||..:|  |..|.:..| |.....
Zfish  1983 ------------------NVKTDQGKES----CEVVLLDENLLKLVH--DNPLYIRSH-CKAILR 2022

  Fly   287 EALQGDNI-----------LTVGRSENSESEECDSGERWTYNTPPDSPRGAQYKEVVYEVDIYDI 340
            .|:..|.:           |.|||.::::                         |:|
Zfish  2023 AAIHSDALFLSSHLIIDYSLLVGRDDSTD-------------------------ELV-------- 2054

  Fly   341 PSIEEKREIYFIAIIDVLTQYGVKKQAAKAAKTVKYGSNVDGI--------STCDPEQYAKRFLD 397
                       :.|||.:..:...|:.....|:.       ||        :...||.|..||.:
Zfish  2055 -----------VGIIDYIRTFTWDKKLEMVVKST-------GILGGQGKMPTVVSPELYRTRFCE 2101

  Fly   398 FMDK 401
            .|||
Zfish  2102 AMDK 2105

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIP4K	NP_001033805.1	PIPKc	32..403	CDD:295374	91/394 (23%)
pikfyve	XP_009302996.1	FYVE_PIKfyve_Fab1	177..238	CDD:277264
		DEP_PIKfyve	387..468	CDD:239895
		Fab1_TCP	665..925	CDD:239450
		PIPKc	1814..2108	CDD:238081	89/378 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900