DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PIP4K and PIP5KL1

DIOPT Version :9

Sequence 1:	NP_001033805.1	Gene:	PIP4K / 3885565	FlyBaseID:	FBgn0039924	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_001128691.1	Gene:	PIP5KL1 / 138429	HGNCID:	28711	Length:	394	Species:	Homo sapiens

Alignment Length:	357	Identity:	97/357 - (27%)
Similarity:	172/357 - (48%)	Gaps:	58/357 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 DDFRAYSKIKVDNHLFNKENMPSHFKVKEYCPLVFRNLRERFGVDDVDYRESLTRSQP-IQIDSS 125
            |||   |::....|        ..|::.......|..||...|:.:.||:.:|....| :|..|:
Human    82 DDF---SEVLTQVH--------EGFELGTLAGPAFAWLRRSLGLAEEDYQAALGPGGPYLQFLST 135

  Fly   126 GKSGAQFYQSYDKFFIIKSLTSEEIERMHAFLKQYHPYVVERHGKTLLPQYLGMYRITVE-SVQY 189
            .||.|.|:.|:|:.|.:|:....|::.:.|.|.:|..: ::||..:||.:.||::.:.|: ..:.
Human   136 SKSKASFFLSHDQRFFLKTQGRREVQALLAHLPRYVQH-LQRHPHSLLARLLGVHSLRVDRGKKT 199

  Fly   190 YFVVMRNVFSSHLTIHKKFDLKGSTVDR------EASEKELEKNLPTFKDNDFIKQKVKLDIGKE 248
            ||:||::||.....|.:::|:||..|.|      |.|...|     ..||.:|  |...:::|.:
Human   200 YFIVMQSVFYPAGRISERYDIKGCEVSRWVDPAPEGSPLVL-----VLKDLNF--QGKTINLGPQ 257

  Fly   249 AKDKLMDTLSNDVDLLTKLHIMDYSLLVG---VHDCVRAEEEALQGDNIL--TVGRSENSES-EE 307
             :...:..:..|...|.:|:::|||||:.   :|     |:|...|.:::  |....:.::| ||
Human   258 -RSWFLRQMELDTTFLRELNVLDYSLLIAFQRLH-----EDERGPGSSLIFRTARSVQGAQSPEE 316

  Fly   308 CDSGERWTYNTPPDSPRGAQYKEVVYEVDIYDIPSIEEKREIYFIAIIDVLTQYGVKKQAAKAAK 372
            ..:..|   ...||:|..         :.|.|.|   |:|  ||:.::|:.|.||::|:.....|
Human   317 SRAQNR---RLLPDAPNA---------LHILDGP---EQR--YFLGVVDLATVYGLRKRLEHLWK 364

  Fly   373 TVKYGSNVDGISTCDPEQYAKRFLDFMDKAIE 404
            |::|....  .||..|.:||:|...:::...|
Human   365 TLRYPGRT--FSTVSPARYARRLCQWVEAHTE 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIP4K	NP_001033805.1	PIPKc	32..403	CDD:295374	96/354 (27%)
PIP5KL1	NP_001128691.1	PIP5K	128..392	CDD:279801	83/296 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1562683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820