DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIP4K and Pip4k2a

DIOPT Version :9

Sequence 1:	NP_001033805.1	Gene:	PIP4K / 3885565	FlyBaseID:	FBgn0039924	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_446378.1	Gene:	Pip4k2a / 116723	RGDID:	621708	Length:	406	Species:	Rattus norvegicus

Alignment Length:	394	Identity:	226/394 - (57%)
Similarity:	287/394 - (72%)	Gaps:	20/394 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KKKHFRVKHQKVKLFRANEPILSVFMWGINHTINELSHVNIPVMLLPDDFRAYSKIKVDNHLFNK 79
            |||||..  ||||||||::|:|||.|||:||:|||||||.|||||:||||:||||||||||||||
  Rat    19 KKKHFVA--QKVKLFRASDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNK 81

  Fly    80 ENMPSHFKVKEYCPLVFRNLRERFGVDDVDYRESLTRSQPIQIDSSGKSGAQFYQSYDKFFIIKS 144
            ||||||||.|||||:||||||||||:||.|::.|||||.|:..||..:|||:|:.||||.::||:
  Rat    82 ENMPSHFKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYVIKT 146

  Fly   145 LTSEEIERMHAFLKQYHPYVVERHGKTLLPQYLGMYRITVESVQYYFVVMRNVFSSHLTIHKKFD 209
            :|||::..||..||:||.|:||.||.|||||:|||||:.|:.|:.|.:|.|||||..|::::|:|
  Rat   147 ITSEDVAEMHNILKKYHQYIVECHGVTLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSVYRKYD 211

  Fly   210 LKGSTVDREASEKELEKNLPTFKDNDFIKQKVKLDIGKEAKDKLMDTLSNDVDLLTKLHIMDYSL 274
            ||||||.||||:||..|.|||.||||||.:..|:.|....|...::.|..||:.|.:|.:|||||
  Rat   212 LKGSTVAREASDKEKAKELPTLKDNDFINEGQKIYIDDSNKKIFLEKLKKDVEFLAQLKLMDYSL 276

  Fly   275 LVGVHDCVRAEEEALQGDNILTVGRSENSESEECDSGERWTYNTPPDSPRGAQYK-------EVV 332
            |||:||..|||:|.::.:        ||...||.:|.......||||||......       |..
  Rat   277 LVGIHDVERAEQEEVECE--------ENEGEEEGESDGAHPIGTPPDSPGNTLNSSPPLAPGEFD 333

  Fly   333 YEVDIYDIPSIEE--KREIYFIAIIDVLTQYGVKKQAAKAAKTVKYGSNVDGISTCDPEQYAKRF 395
            ..:|:|.|...|.  ::|:||:||||:||.|..||:||.||||||:|:..: |||.:||||:|||
  Rat   334 PNIDVYAIKCHENAPRKEVYFMAIIDILTHYDAKKKAAHAAKTVKHGAGAE-ISTVNPEQYSKRF 397

  Fly   396 LDFM 399
            |||:
  Rat   398 LDFI 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIP4K	NP_001033805.1	PIPKc	32..403	CDD:295374	213/377 (56%)
Pip4k2a	NP_446378.1	PIPKc_PIP5K2A	27..403	CDD:340446	220/384 (57%)
		Required for interaction with PIP5K1A. /evidence=ECO:0000250\|UniProtKB:Q8TBX8	59..65		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..328		13/48 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	281	1.000	Domainoid score	I1597
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	455	1.000	Inparanoid score	I1537
OMA	1	1.010	-	-		QHG52363
OrthoDB	1	1.010	-	-		D1562683at2759
OrthoFinder	1	1.000	-	-		FOG0001219
OrthoInspector	1	1.000	-	-		otm45659
orthoMCL	1	0.900	-	-		OOG6_104901
Panther	1	1.100	-	-	O	PTHR23086
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X950
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980