DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PIP4K and Pip4k2b

DIOPT Version :9

Sequence 1:	NP_001033805.1	Gene:	PIP4K / 3885565	FlyBaseID:	FBgn0039924	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_473392.1	Gene:	Pip4k2b / 108083	MGIID:	1934234	Length:	416	Species:	Mus musculus

Alignment Length:	403	Identity:	232/403 - (57%)
Similarity:	297/403 - (73%)	Gaps:	25/403 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KKKHFRVKHQKVKLFRANEPILSVFMWGINHTINELSHVNIPVMLLPDDFRAYSKIKVDNHLFNK 79
            |||||..  ||||||||:||||||.|||:||||||||:|.:||||:||||:||||||||||||||
Mouse    24 KKKHFVC--QKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNK 86

  Fly    80 ENMPSHFKVKEYCPLVFRNLRERFGVDDVDYRESLTRSQPIQIDSSGKSGAQFYQSYDKFFIIKS 144
            ||:||.||.|||||:||||||||||:||.||:.|:|||.||..||.|:.|.:|..:||:.|:||:
Mouse    87 ENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKT 151

  Fly   145 LTSEEIERMHAFLKQYHPYVVERHGKTLLPQYLGMYRITVESVQYYFVVMRNVFSSHLTIHKKFD 209
            ::||::..||..||:||.::||.||.|||||:|||||:||:.|:.|.||.|||||..||:|:|:|
Mouse   152 VSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYD 216

  Fly   210 LKGSTVDREASEKELEKNLPTFKDNDFIKQKVKLDIGKEAKDKLMDTLSNDVDLLTKLHIMDYSL 274
            ||||||.||||:||..|:|||||||||:.:..||.:|:|:|...::.|..||:.|.:|.||||||
Mouse   217 LKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSL 281

  Fly   275 LVGVHDCVRAEEEALQGDNILTVGRSENSESEECDS-----GERWTYNTPPDS-------PRGAQ 327
            |||:||..|||:|.::.:        |.:|.|||::     ....:|.|||||       ||...
Mouse   282 LVGIHDVDRAEQEEMEVE--------ERAEEEECENDGVGGSLLCSYGTPPDSPGNLLSFPRFFG 338

  Fly   328 YKEVVYEVDIYDIPSIEE--KREIYFIAIIDVLTQYGVKKQAAKAAKTVKYGSNVDGISTCDPEQ 390
            ..|....||:|.:.|.|.  |:|:||:||||:||.|..||:||.||||||:|:..: |||.:|||
Mouse   339 PGEFDPSVDVYAMKSHESAPKKEVYFMAIIDILTPYDAKKKAAHAAKTVKHGAGAE-ISTVNPEQ 402

  Fly   391 YAKRFLDFMDKAI 403
            |:|||.:||...:
Mouse   403 YSKRFNEFMSNIL 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIP4K	NP_001033805.1	PIPKc	32..403	CDD:295374	219/384 (57%)
Pip4k2b	NP_473392.1	PIPKc_PIP5K2B	30..413	CDD:340447	227/393 (58%)
Pip4k2b	NP_473392.1	Required for interaction with PIP5K1A. /evidence=ECO:0000250\|UniProtKB:Q8TBX8	64..70		4/5 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	281	1.000	Domainoid score	I1661
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2634
Inparanoid	1	1.050	455	1.000	Inparanoid score	I1579
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52363
OrthoDB	1	1.010	-	-		D1562683at2759
OrthoFinder	1	1.000	-	-		FOG0001219
OrthoInspector	1	1.000	-	-		otm43587
orthoMCL	1	0.900	-	-		OOG6_104901
Panther	1	1.100	-	-	LDO	PTHR23086
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2198
SonicParanoid	1	1.000	-	-		X950
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.870