DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PIP4K and pip4k2cb

DIOPT Version :9

Sequence 1:	NP_001033805.1	Gene:	PIP4K / 3885565	FlyBaseID:	FBgn0039924	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	XP_003199456.1	Gene:	pip4k2cb / 100535634	ZFINID:	ZDB-GENE-141212-236	Length:	416	Species:	Danio rerio

Alignment Length:	401	Identity:	214/401 - (53%)
Similarity:	280/401 - (69%)	Gaps:	27/401 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KKKHFRVKHQKVKLFRANEPILSVFMWGINHTINELSHVNIPVMLLPDDFRAYSKIKVDNHLFNK 79
            |||||  .||||::|.|::|||:|||||||||||:|..|.:|||||||||:|..|:||:||||||
Zfish    21 KKKHF--VHQKVEVFWASDPILTVFMWGINHTINDLFQVPMPVMLLPDDFKANIKMKVNNHLFNK 83

  Fly    80 ENMPSHFKVKEYCPLVFRNLRERFGVDDVDYRESLTRSQPIQIDSSGKSGAQFYQSYDKFFIIKS 144
            ||:|.|||.|||||||||||||||||:..||:.|||||.|::.|...::.....:|||:..|:|.
Zfish    84 ENLPGHFKFKEYCPLVFRNLRERFGVEHQDYQVSLTRSPPVKDDKEEEAVLLLLKSYDRTLIVKQ 148

  Fly   145 LTSEEIERMHAFLKQYHPYVVERHGKTLLPQYLGMYRITVESVQYYFVVMRNVFSSHLTIHKKFD 209
            ::|||:|.||..|.:||.::|..||.|||||:|||||:||::...|.:||||:||..||||:|:|
Zfish   149 ISSEEVEDMHNILSEYHQHIVTCHGSTLLPQFLGMYRVTVDNEDTYLLVMRNMFSHRLTIHRKYD 213

  Fly   210 LKGSTVDREASEKELEKNLPTFKDNDFIKQKVKLDIGKEAKDKLMDTLSNDVDLLTKLHIMDYSL 274
            ||||.|.||||:||..|.||||||.||.....::.|..|.|:||:|.|:.||:.|.:|.||||||
Zfish   214 LKGSLVSREASDKEKVKELPTFKDVDFRNNMQRVYISDEEKEKLLDKLNRDVEFLVRLKIMDYSL 278

  Fly   275 LVGVHDCVRAEEEALQGDNILTVGRSENSESEECDSGER-------WTYNTPPDSPRG--AQYK- 329
            |:|:||..|||:|..:        ..::|.|||.:..|.       .::.|.|:...|  :.||
Zfish   279 LLGIHDVGRAEQEEEE--------EMKDSLSEEEEDSENDLHLPAVGSFGTSPEGIAGYMSSYKA 335

  Fly   330 ----EVVYEVDIYDIPSIEEK--REIYFIAIIDVLTQYGVKKQAAKAAKTVKYGSNVDGISTCDP 388
                |....||:|.|.|::..  ||:||:.:||:||||..||:||.||||||:|:..: |||..|
Zfish   336 LGPGEFDPFVDVYAIQSVDGAPCREVYFMGLIDILTQYDTKKRAAHAAKTVKHGAGAE-ISTVHP 399

  Fly   389 EQYAKRFLDFM 399
            |||||||.:|:
Zfish   400 EQYAKRFREFI 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIP4K	NP_001033805.1	PIPKc	32..403	CDD:295374	203/384 (53%)
pip4k2cb	XP_003199456.1	PIPKc	64..414	CDD:214623	183/356 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1902
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	431	1.000	Inparanoid score	I1688
OMA	1	1.010	-	-		QHG52363
OrthoDB	1	1.010	-	-		D1562683at2759
OrthoFinder	1	1.000	-	-		FOG0001219
OrthoInspector	1	1.000	-	-		otm25941
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23086
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X950
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.940