Protein Alignment t-Grip84 and TUBGCP4

DIOPT Version :10

• Sequence 1: NP_648139.1
• Gene: t-Grip84 / 38852
• FlyBaseID: FBgn0035800
• Length: 728
• Species: Drosophila melanogaster
• Sequence 2: NP_001273343.1
• Gene: TUBGCP4 / 27229
• HGNCID: 16691
• Length: 667
• Species: Homo sapiens
• Alignment Length: 709
• Identity: 145/709 - (20%)
• Similarity: 271/709 - (38%)
• Gaps: 152/709 - (21%)

  Fly    94 LMRDLIYAFSGVPSAYV----KPDIQIDQ------ISEMSAVDIAKIRFRLKKTFTGAFRALANE 148
            ::.:|:.|.||.|.:..    :..:|:.|      .||.|.::      ||.:        |..:
Human     1 MIHELLLALSGYPGSIFTWNKRSGLQVSQDFPFLHPSETSVLN------RLCR--------LGTD 51

  Fly   149 TLPLIGYYISVQSYIEETNMSPN-CGRTRL------TLATALSDQLQDYYDLQSKLETD-LQDKK 205
            .:....:......::::.:..|: .|:..|      ...|.|...||.|......||.: |.|..
Human    52 YIRFTEFIEQYTGHVQQQDHHPSQQGQGGLHGIYLRAFCTGLDSVLQPYRQALLDLEQEFLGDPH 116

  Fly   206 LDLKDL---VRQVRPWLPILKTFSNMASSARGNLTSAQVLTLLDQFYRDLKDTDIDLKERVNKIL 267
            |.:..:   :.|.:...|.:........|.:  :...|:   |:..|:........::..:.|||
Human   117 LSISHVNYFLDQFQLLFPSVMVVVEQIKSQK--IHGCQI---LETVYKHSCGGLPPVRSALEKIL 176

  Fly   268 TSTSRAYMKIVQLWMQKGVLFDTQHEFFVEDTEPSSTMSS------------------------- 307
            ........|.:..||..|:|.|...|||::....|..:|:
Human   177 AVCHGVMYKQLSAWMLHGLLLDQHEEFFIKQGPSSGNVSAQPEEDEEDLGIGGLTGKQLRELQDL 241

  Fly   308 ------TLLAPEKCCHAYWAERYRLLPDRLPGFLLSQADDIFLAGKYLNILRQCNVSL------- 359
                  .:|||..   ..::.|..:||..:|   :..|:.|...|:.:.:....||:|
Human   242 RLIEEENMLAPSL---KQFSLRVEILPSYIP---VRVAEKILFVGESVQMFENQNVNLTRKGSIL 300

  Fly   360 ------------KLLQRPLAYSQGDLGHEEIIKTSYELPAHKFLKVLVEEHNLPLHIRNLKSYFL 412
                        :|.|:|| :|..|.  |:::.......|....|::|||.:|...::.:|.::|
Human   301 KNQEDTFAAELHRLKQQPL-FSLVDF--EQVVDRIRSTVAEHLWKLMVEESDLLGQLKIIKDFYL 362

  Fly   413 LQEEGFSETFLHKCHEYLKYNVERLIPEKLQTLLAETLHK--SNDFIKDNVRCQLKVCDVATLLG 475
            |......:.|:......||.....:....:.....::.||  .:|   ||:...|.:  .....|
Human   363 LGRGELFQAFIDTAQHMLKTPPTAVTEHDVNVAFQQSAHKVLLDD---DNLLPLLHL--TIEYHG 422

  Fly   476 RQHKAQRAVEDEEEEEKESCSEQDPPEVLNLYGYEALALGYETKWPLSFIIYPELLEQLQMLQRV 540
            ::|||. |.:..|...:|:...:.|..     |:.||.|.|:.:|||..:..|.:||:..::.:.
Human   423 KEHKAD-ATQAREGPSRETSPREAPAS-----GWAALGLSYKVQWPLHILFTPAVLEKYNVVFKY 481

  Fly   541 LFFLHYVKHHLTVLWQSPCEGTGLQLTNRSG----KLRHRMLMCMLSLENHIIQDITEPRWQSLT 601
            |..:..|:..|...|....:...|: :|::.    :||:.|...:.:|:.::..|:.|.::..|
Human   482 LLSVRRVQAELQHCWALQMQRKHLK-SNQTDAIKWRLRNHMAFLVDNLQYYLQVDVLESQFSQL- 544

  Fly   602 LTVDKAKCIDEVLNKLESTVE-ECLRL-------GLLPTANTFVKSLY----TLGHVCLNFCDFV 654
                        |:::.||.: |.:||       .||..:...:|.::    .:..:|.:||..|
Human   545 ------------LHQINSTRDFESIRLAHDHFLSNLLAQSFILLKPVFHCLNEILDLCHSFCSLV 597

  Fly   655 ESSIG---EKSTKELEQEVVEYEEEFKSFLTSILELVSQLAKTKDIAERDSCKQLLKRL 710
            ..::|   |:...:|...|..:..: .|.|..||..|.......|:|      |||.||
Human   598 SQNLGPLDERGAAQLSILVKGFSRQ-SSLLFKILSSVRNHQINSDLA------QLLLRL 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
t-Grip84	NP_648139.1	GCP_N_terminal	96..397	CDD:465456	69/371 (19%)
		GCP_C_terminal	400..710	CDD:461187	72/330 (22%)
TUBGCP4	NP_001273343.1	GCP_N_terminal	2..347	CDD:465456	69/372 (19%)
		GCP_C_terminal	350..655	CDD:461187	74/332 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	425..445		6/20 (30%)