Protein Alignment t-Grip84 and TUBGCP2

DIOPT Version :10

• Sequence 1: NP_648139.1
• Gene: t-Grip84 / 38852
• FlyBaseID: FBgn0035800
• Length: 728
• Species: Drosophila melanogaster
• Sequence 2: NP_001243546.1
• Gene: TUBGCP2 / 10844
• HGNCID: 18599
• Length: 930
• Species: Homo sapiens
• Alignment Length: 787
• Identity: 201/787 - (25%)
• Similarity: 337/787 - (42%)
• Gaps: 154/787 - (19%)

  Fly    22 ELERQMRKIHDREESVDEKMRPSGSENSGHNCNTSSSSSLPRQESWIFES---VGGYF------- 76
            ||:|:|  :.|::          ..:|||.:        ||...:|::|.   :|.:.
Human   155 ELKRKM--LRDKQ----------NKKNSGQH--------LPIFPAWVYERPALIGDFLIGAGIST 199

  Fly    77 -------LANENLA---------------------KMSLPCQEQLLMRDLIYAFSGVPSAYVKPD 113
                   |...|||                     .:.|..||..::.||:|...||...||
Human   200 DTALPIVLLRWNLALSPRLKCSGVISAHCNLHLPGTLPLASQESAVVEDLLYVLVGVDGRYV--- 261

  Fly   114 IQIDQISEMSAVDIAKIRFRLKKTFTG------AFRALANETLPLIGYYISVQSYIEETNMSPNC 172
                     ||..:|.   |..:||..      :.|.|.:..||:...|.:|..:|||.: |...
Human   262 ---------SAQPLAG---RQSRTFLVDPNLDLSIRELVHRILPVAASYSAVTRFIEEKS-SFEY 313

  Fly   173 GRTRLTLATALSDQLQDYYDLQSKLETDLQDKKLDLKDLVRQVRPWLPILKTFSNMASSA-RGNL 236
            |:....||.|:...::::..|.|:||...:...|.|:.|...::|.:..:...:::|:|. :|..
Human   314 GQVNHALAAAMRTLVKEHLILVSQLEQLHRQGLLSLQKLWFYIQPAMRTMDILASLATSVDKGEC 378

  Fly   237 TSAQVLTLLDQFYRDLKDT-DIDLKERVNKILTSTSRAYMKIVQLWMQKGVLFDTQHEFFVEDTE 300
            .....|:||..  |....| |...:|....:..:.|..|.::::.|:.:|::.|...||.||:.|
Human   379 LGGSTLSLLHD--RSFSYTGDSQAQELCLYLTKAASAPYFEVLEKWIYRGIIHDPYSEFMVEEHE 441

  Fly   301 PSSTMSSTLLAPEKCCH----AYWAERYRLLPDRLPGFLLSQADDIFLAGKYLNILRQCNVSLKL 361
                     |..|:...    .||.:||.::..::|.||...||.|...|||||::|:|...:..
Human   442 ---------LRKERIQEDYNDKYWDQRYTIVQQQIPSFLQKMADKILSTGKYLNVVRECGHDVTC 497

  Fly   362 -LQRPLAYSQGDLGHEEIIKTSYELPAHKFLKVLVEEHNLPLHIRNLKSYFLLQEEGFSETFLHK 425
             :.:.:.|:..:..:.|.|:.::...:...|..|:||..|..|:|::|.|||:.:..|...|:..
Human   498 PVAKEIIYTLKERAYVEQIEKAFNYASKVLLDFLMEEKELVAHLRSIKRYFLMDQGDFFVHFMDL 562

  Fly   426 CHEYLKYNVERLIPEKLQTLLAETLHKS---NDFIKDNVRCQLKVCDVATLLGRQHKAQRAVEDE 487
            ..|.|:..||.:.|.:|:.||...|..|   .|..||:::..|...|:.|.|.|    ..|:|.:
Human   563 AEEELRKPVEDITPPRLEALLELALRMSTANTDPFKDDLKIDLMPHDLITQLLR----VLAIETK 623

  Fly   488 EEEEKESCSEQDPPEVLNLYGYEALALGYETKWPLSFIIYPELLEQLQMLQRVLFFLHYVKHHLT 552
            :|   ::.:..||.| |.|.|.||.:..|..|||||.||..:.|.:.|||.|.:|:..:|:..|.
Human   624 QE---KAMAHADPTE-LALSGLEAFSFDYIVKWPLSLIINRKALTRYQMLFRHMFYCKHVERQLC 684

  Fly   553 VLWQSPCEGTGLQLTNRSGK---------------LRHRMLMCMLSLENHIIQDITEPRWQSLTL 602
            .:|          ::|::.|               ||.|||..:.:::.:::.::.||.|..|..
Human   685 SVW----------ISNKTAKQHSLHSAQWFAGAFTLRQRMLNFVQNIQYYMMFEVMEPTWHILEK 739

  Fly   603 TVDKAKCIDEVLNKLESTVEECLRLGLLPTANTFVKSLYTLGHVCLNFCD----FVESS--IGEK 661
            .:..|..||:||......::.||:..:| |....:|....|..||:.|.:    |.:|.  .||.
Human   740 NLKSASNIDDVLGHHTGFLDTCLKDCML-TNPELLKVFSKLMSVCVMFTNCMQKFTQSMKLDGEL 803

  Fly   662 STKELEQEVV-----EYEEEFKSFL--------TSILELVSQLAKTKDIAERDSCKQLLKRLGEL 713
            ..:.||...|     ..||..:..|        ...::|||....|.:..:::....||..|..|
Human   804 GGQTLEHSTVLGLPAGAEERARKELARKHLAEHADTVQLVSGFEATINKFDKNFSAHLLDLLARL 868

  Fly   714 IEFSDLD 720
            ..:|..|
Human   869 SIYSTSD 875

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
t-Grip84	NP_648139.1	GCP_N_terminal	96..397	CDD:465456	79/313 (25%)
		GCP_C_terminal	400..710	CDD:461187	96/346 (28%)
TUBGCP2	NP_001243546.1	GCP_N_terminal	246..534	CDD:465456	79/314 (25%)
		GCP_C_terminal	537..893	CDD:461187	100/358 (28%)