DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG14838 and DYNC2I2

DIOPT Version :9

Sequence 1:NP_648138.1 Gene:CG14838 / 38851 FlyBaseID:FBgn0035799 Length:1132 Species:Drosophila melanogaster
Sequence 2:NP_443076.2 Gene:DYNC2I2 / 89891 HGNCID:28296 Length:536 Species:Homo sapiens


Alignment Length:639 Identity:113/639 - (17%)
Similarity:203/639 - (31%) Gaps:213/639 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   256 ENIKWENVTKKRVNVSVQSAPPK----IEREQQTNPTFPSNAWSQYLYEIDDEDLELDETDVDEE 316
            :.|:||..:.:..:::..||..:    ::.:.||....|.:......|:|               
Human    56 QGIRWETKSCQTASIATASASAQARNHVDAQVQTEAPVPVSVQPPSQYDI--------------- 105

  Fly   317 EEKKKAQAKPGTYVEPEKKPPEMSA---QIE-MLLNTLEFN----QIDSYRDDYSLISSRQVVQY 373
                                |.::|   ::| |::..|..|    ..|.:..:::  ..:|:|. 
Human   106 --------------------PRLAAFLRRVEAMVIRELNKNWQSHAFDGFEVNWT--EQQQMVS- 147

  Fly   374 TNPYLQEFLCFANISKSNKRFVAGYDWYP--KLSGLIAVSYAF-STPATVNEATNRVDYVQRAVL 435
                     |...:.            ||  :..||...|.:: ||.:.|..|..|:|:...:.|
Human   148 ---------CLYTLG------------YPPAQAQGLHVTSISWNSTGSVVACAYGRLDHGDWSTL 191

  Fly   436 EPNPVLLWSFSDNLNYKLE-----FEAPIETTALTFCPFNGDILLGGSKNGQVVLWDLQGRCEKL 495
            : :.|..|:. |..:.:.:     .|.|.....|.|.|.....:.||..:|:|::|||    .:|
Human   192 K-SFVCAWNL-DRRDLRPQQPSAVVEVPSAVLCLAFHPTQPSHVAGGLYSGEVLVWDL----SRL 250

  Fly   496 DEEEYLTAAQAKYRIMIGEFLNWTIDIEDNVIVPATISLLDCSPKGAITAFYWLGRSIYLSQFGK 560
            ::.                 |.|...:.|:            :....::...||           
Human   251 EDP-----------------LLWRTGLTDD------------THTDPVSQVVWL----------- 275

  Fly   561 VYNDPDIRNHHKFFV-TCAFDGTISFWDLDGKGGKSAKDKMRNRMLPKELTQSESAFKSMVIKPT 624
                |:..:.|:|.| :.|.||.:..|...|.|             ..:||:..:.....:.:.|
Human   276 ----PEPGHSHRFQVLSVATDGKVLLWQGIGVG-------------QLQLTEGFALVMQQLPRST 323

  Fly   625 YNLYFPEPITGIIADTSCLSCLTPVAKLIQANPSNYPIKTIAKDPPTMRQSMIVSTFYGHVSRID 689
            .....|...|.:.|.....|...| ...|......:|:|.                         
Human   324 KLKKHPRGETEVGATAVAFSSFDP-RLFILGTEGGFPLKC------------------------- 362

  Fly   690 WQGTYTEGEATEV-INSSIPFA-------MVHDGPVVMVKKNPFYPELFASIGRTILAIWKEDYN 746
               :...|||... :.||:|..       ..|.||:..|..:||:..||.|.|..         .
Human   363 ---SLAAGEAALTRMPSSVPLRAPAQFTFSPHGGPIYSVSCSPFHRNLFLSAGTD---------G 415

  Fly   747 YSPIFWRKRACDLT----------AVAWSETRPAVLYLTRIDGILEAWDILARDDDACLTEILGG 801
            :..::...:|..||          ||.||..||.|.......|.::.:|:........:      
Human   416 HVHLYSMLQAPPLTSLQLSLKYLFAVRWSPVRPLVFAAASGKGDVQLFDLQKSSQKPTV------ 474

  Fly   802 GIITAITEHRP-------SLPHKILGIGDYNSSIRMVKLPHSFDVPLPNELDQL 848
             :|....:..|       |...::|..||...::::.:|...|....|.|.:.|
Human   475 -LIKQTQDESPVYCLEFNSQQTQLLAAGDAQGTVKVWQLSTEFTEQGPREAEDL 527

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG14838NP_648138.1 WD40 328..>599 CDD:225201 53/287 (18%)
WD40 repeat 462..505 CDD:293791 11/42 (26%)
WD40 repeat 510..547 CDD:293791 3/36 (8%)
RE_R_Pab1 807..>863 CDD:286594 10/49 (20%)
DYNC2I2NP_443076.2 DYNLL2 binding. /evidence=ECO:0000269|PubMed:30649997 80..93 2/12 (17%)
WD40 106..516 CDD:225201 99/541 (18%)
DYNLRB1 binding. /evidence=ECO:0000269|PubMed:30649997 106..131 6/24 (25%)
WD40 repeat 164..215 CDD:293791 11/52 (21%)
WD 1. /evidence=ECO:0000255 215..255 13/60 (22%)
WD40 217..515 CDD:295369 73/403 (18%)
WD40 repeat 220..264 CDD:293791 14/76 (18%)
WD 2. /evidence=ECO:0000255 264..308 12/71 (17%)
WD40 repeat 270..325 CDD:293791 15/82 (18%)
WD40 repeat 337..389 CDD:293791 12/80 (15%)
WD 3. /evidence=ECO:0000255 390..430 12/48 (25%)
WD40 repeat 396..432 CDD:293791 10/44 (23%)
WD 4. /evidence=ECO:0000255 433..473 9/39 (23%)
WD40 repeat 438..476 CDD:293791 9/44 (20%)
WD 5. /evidence=ECO:0000255 480..520 7/39 (18%)
WD40 repeat 485..512 CDD:293791 4/26 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1587
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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