DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14838 and dnai2a

DIOPT Version :9

Sequence 1:	NP_648138.1	Gene:	CG14838 / 38851	FlyBaseID:	FBgn0035799	Length:	1132	Species:	Drosophila melanogaster
Sequence 2:	XP_017213955.1	Gene:	dnai2a / 563648	ZFINID:	ZDB-GENE-070410-46	Length:	567	Species:	Danio rerio

Alignment Length:	703	Identity:	131/703 - (18%)
Similarity:	253/703 - (35%)	Gaps:	165/703 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 PIDVEIQSVY--PIQMPRHVAFDYRMTRDVRDGVLELLPNENIKWENVTKKRVNVSVQSAPPKIE 280
            |:..:::..|  .|:..|...|..:..  |.|   ::.|:.::..|.:.:...:|..|.:  |..
Zfish     8 PLAFKMEMTYQQKIESGRWCKFSEKAV--VHD---DIPPDPSLALEYIDRGTCHVGTQFS--KFW 65

  Fly   281 REQQTNP----------TFPSNAWSQYLYEIDDEDLELDETDVDEEEEKKKAQAKPGTYVEPEKK 335
            .:.:..|          ......|.:.:...:||........|.::|..::...:..:.:|..|:
Zfish    66 SQHEVTPFHTEQVSHGMNHVEGGWPETISANNDELTLRYRKKVQKDESYQQTVIETVSVMENYKQ 130

  Fly   336 PPEMSAQIEMLLNTLEFNQIDSYRDDYSLISSRQVVQYTNPYLQEFLCFANISKSNKRFVAGYDW 400
            .....:|:     ..:.|::...|:|  :.|:|.:....:|            |..||......|
Zfish   131 KVFEKSQV-----YFKDNRVVVKRED--MASARIINVLRDP------------KKEKRAATSLSW 176

  Fly   401 YPKLSGLIAVSYAFSTPATVNEATNRVDYVQRAVLEPNPVLLWSFSDNLNYKLEFEAPIETTALT 465
            :|..:..:||:|:.            |::.:......:...:|:..:|...::..::......|.
Zfish   177 HPVDNHKLAVAYSC------------VEFQRGPKNMSSDSYIWNIENNKQPEMTLKSVSPLVCLE 229

  Fly   466 FCPFNGDILLGGSKNGQVVLWDLQGRCEKLDEEEYLTAAQAKYRIMIGEFLNWTIDIEDNVIVPA 530
            :...|..||:|||.|||:..||.:...:                                   |.
Zfish   230 YNLKNISILIGGSYNGQIGYWDTRSGSQ-----------------------------------PV 259

  Fly   531 TISLLDCSPKGAITAFYWLGRSIYLSQFGKVYNDPDIRNHHKFFVTCAFDGTISFWDLDGKGGKS 595
            .||.::.|.|..:....||...|....|                 :.:.||.:.|||:... .:.
Zfish   260 QISAIEHSHKDPVYKVIWLQTKIGTEAF-----------------SASTDGQVLFWDIRNM-SEP 306

  Fly   596 AKDKMRNRMLPKELTQSESAFKSMVIKPTYNLYFPEPITGIIADTSCLSCLTPVAKLIQANPSNY 660
            .|..:.:....|.|..:..|| ||....|    .|:.:.|           |....::..|.
Zfish   307 TKQLILDPAKSKNLNNAFGAF-SMEFDNT----MPKFLVG-----------TEQGLVVLCNR--- 352

  Fly   661 PIKTIAKDPPTMRQSMIVSTFYGHVSRIDWQGTYTEGEATEVINSSIPFAMVHDGPVVMVKKNPF 725
              |....|.|      ||.|:.||:                             |||..|::|||
Zfish   353 --KLETTDEP------IVCTYSGHL-----------------------------GPVYAVQRNPF 380

  Fly   726 YPELFASIGRTILAIWKEDYNYSPIFWRK-RACDLTAVAWSETRPAVLYLTRIDGILEAWDILAR 789
            :|:.|.::......||.||...|.|...| ....|....||..||||.:..::||.|:.||||.:
Zfish   381 FPKYFLTVADWTARIWSEDIRLSSIMSTKYHTSHLMDGCWSPVRPAVFFTVKMDGTLDVWDILLK 445

  Fly   790 DDDACLTEILGGGIITAITEHRPSLPHKILGIGDYNSSIRMVKLPHSFDVPLPNELDQLIKYVLK 854
            ..|..|:..:....:.:|.....|   .::..|....::.::|:..:......||...:.:...:
Zfish   446 QKDPVLSLKVCDETLYSIRVKNDS---PLMCCGSQLGTVTLLKMSPNLCTLQSNEKGLVSEMFER 507

  Fly   855 EERRKMGIQSWEQKYYELNKDIIEAKREAAAEIRKEMEKKEKE--EQLASRKK 905
            |.:|:..::::.::..::.:...:.:.:..||:::.:.:.|.|  |.:...||
Zfish   508 ETKREKILEAFYKERNQMKQSCPKEEEDGRAELQELLAETETEFFEAINVEKK 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14838	NP_648138.1	WD40	328..>599	CDD:225201	47/270 (17%)
		WD40 repeat	462..505	CDD:293791	12/42 (29%)
		WD40 repeat	510..547	CDD:293791	5/36 (14%)
		RE_R_Pab1	807..>863	CDD:286594	8/55 (15%)
dnai2a	XP_017213955.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595652
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56355
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.950