DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14838 and dync1i2b

DIOPT Version :9

Sequence 1:	NP_648138.1	Gene:	CG14838 / 38851	FlyBaseID:	FBgn0035799	Length:	1132	Species:	Drosophila melanogaster
Sequence 2:	XP_009300385.1	Gene:	dync1i2b / 561612	ZFINID:	ZDB-GENE-090121-1	Length:	645	Species:	Danio rerio

Alignment Length:	711	Identity:	122/711 - (17%)
Similarity:	220/711 - (30%)	Gaps:	295/711 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 PPKIEREQQTNPTFPSNAWSQYLYEI---------DDEDLELD--------ETDVDEEEEKKKAQ 323
            |.|:...:.|...||......|..|.         :||:.|.|        |...:::.:|::.:
Zfish   145 PLKLGMSKVTQVDFPPKEMVSYSKETQTPTQTHHKEDEEEEEDLAVMQPVMEPQEEKDSQKEEDE 209

  Fly   324 AKPGTYVEPEKKPPEMSAQIEMLLNTLEF----------------NQIDSYRDDYS--------- 363
            |.|....|.||         :.:|::.||                .|:|.: .|||
Zfish   210 ASPHELTEEEK---------QQILHSEEFVTFFDHSSRIMERALSEQVDVF-FDYSGRDLQDKEG 264

  Fly   364 -------LISSRQVVQYTNPYLQEFLCFANISKSNKRFVAGYDWYPKLSGLIAVSYAFSTPATVN 421
                   |..:||              ||:...|..|.|...||.|:...|:..||..:
Zfish   265 ESQAGAKLSLNRQ--------------FADERWSKHRVVTCLDWSPQYPELLVASYCSN------ 309

  Fly   422 EATNRVDYVQRAVLEPNPV-LLWSFSDNLNYK-----LEFEAPIETTALTFCPFNGDILLGGSKN 480
                     :.|..||:.| |:|    |:.||     ..|.......:..|..|:.::::||:.:
Zfish   310 ---------EEAPHEPDGVALVW----NMKYKKTTPEYVFHCQSAVMSAAFAQFHPNLVVGGTYS 361

  Fly   481 GQVVLWDLQGRCEKLDEEEYLTAAQAKYRIMI------------------GEFLNWTIDIEDNVI 527
            ||:||||.:.......:...|:|:...:.:..                  |:..:|::|:..
Zfish   362 GQIVLWDNRSNKRTPVQRTPLSASAHTHPVYCVNVVGTQNAHNLISISTDGKMCSWSLDMLS--- 423

  Fly   528 VPATISLLDCSPKGAITAFYWLGRSIYLSQFGKVYNDPDIRNHHKFFVTCAFDGTISFWDLDGKG 592
                      :|:.::...:...:|:.::...  :...|:.|    ||..:.||::  :.....|
Zfish   424 ----------TPQDSLELVFKQSKSVAVTSMS--FPLGDVNN----FVVGSEDGSV--YTACRHG 470

  Fly   593 GKSAKDKMRNRMLPKELTQSESAFKSMVIKPTYNLYFPEPITGIIADTSCLSCLTPVAKLIQANP 657
            .|:...:|               |:.          ...||||       |.|.|
Zfish   471 SKAGISEM---------------FEG----------HHGPITG-------LDCHT---------- 493

  Fly   658 SNYPIKTIAKDPPTMRQSMIVSTFYGHVSRIDWQGTYTEGEATEVINSSIPFAMVHDGPVVMVKK 722
                    |..|.......:.|:|       ||....              ::..::.|:...:.
Zfish   494 --------AAGPVDFSHLFVTSSF-------DWTVKL--------------WSTKNNKPLYSFED 529

  Fly   723 NPFYPELFASIGRTILAIWKEDYNYSPIFWRKRACDLTAVAWSETRPAVLYLTRIDGI--LEAWD 785
            |                   .||.|.             |.||.|.||:  ...:||:  |:.|:
Zfish   530 N-------------------SDYVYD-------------VMWSPTHPAL--FACVDGVGHLDLWN 560

  Fly   786 ILARDDDACLTEILGGGIITAITEHRPSLPH-------KILGIGDYNSSIRMVKLPHSFDVPLPN 843
            :...      ||:....:   ..|..|:|..       :.:.:||....:.:..:.....||..:
Zfish   561 LNNE------TEVPTASV---TVEGNPALNRVRWAHSGREVAVGDSEGQLHIYDVGEQISVPRQD 616

  Fly   844 ELDQLIKYVLKEERRKMGIQSWEQKYYELNKDIIEAKREAAAEIRKEMEKKEKEEQLASRK 904
            |..:.::.:.                 |:|                  |.:|..|:||:::
Zfish   617 EWTRFVRTLT-----------------EIN------------------ENREDVEELAAQR 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14838	NP_648138.1	WD40	328..>599	CDD:225201	60/326 (18%)
		WD40 repeat	462..505	CDD:293791	12/42 (29%)
		WD40 repeat	510..547	CDD:293791	4/54 (7%)
		RE_R_Pab1	807..>863	CDD:286594	8/62 (13%)
dync1i2b	XP_009300385.1	Dynein_IC2	145..173	CDD:288403	7/27 (26%)
		Spore_coat_CotO	153..>256	CDD:290858	23/112 (21%)
		WD40	283..605	CDD:295369	81/475 (17%)
		WD40 repeat	289..338	CDD:293791	17/67 (25%)
		WD40 repeat	343..382	CDD:293791	10/38 (26%)
		WD40	362..>606	CDD:225201	58/378 (15%)
		WD40 repeat	391..434	CDD:293791	4/55 (7%)
		WD40 repeat	442..490	CDD:293791	14/87 (16%)
		WD40 repeat	497..528	CDD:293791	6/51 (12%)
		WD40 repeat	534..575	CDD:293791	13/64 (20%)
		WD40 repeat	580..606	CDD:293791	3/25 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910