DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14838 and dync1i1

DIOPT Version :9

Sequence 1:	NP_648138.1	Gene:	CG14838 / 38851	FlyBaseID:	FBgn0035799	Length:	1132	Species:	Drosophila melanogaster
Sequence 2:	XP_009290517.1	Gene:	dync1i1 / 561525	ZFINID:	ZDB-GENE-061215-62	Length:	647	Species:	Danio rerio

Alignment Length:	760	Identity:	128/760 - (16%)
Similarity:	247/760 - (32%)	Gaps:	247/760 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 ERWRMQRRLRKKPRRWVSHGTDEEMTIMVERFKDEPIDVEIQSVYPIQMPRHVAFDYRMTRDVRD 247
            :|..::..|.:|.:| ::...:|:.....||.|.|.   |:     :|.|.:|..|..:.|..|:
Zfish     3 DRSDLKAELERKKQR-LAQIREEKKRKEEERKKKES---EM-----LQRPENVTEDSDLDRKRRE 58

  Fly   248 --------GV---------LELLPNENIKWENVTKKRVNVSVQSAPPKIEREQQTN--------- 286
                    |:         |:||..:...:..:....::.|.||..|..|...|.:
Zfish    59 TEALLQSIGISPEPPLVQPLQLLTWDTCYFHYLVPTPMSPSSQSVSPPSETGSQESIDGGTVERY 123

  Fly   287 -----PTFPS---------------NAWSQYLYEIDDEDLEL-------------DETDVDEEEE 318
                 .|.||               ...:..:.:||....||             ::.:.:::||
Zfish   124 RTLQWDTDPSALQLLADSVHGCRMQRLGASKIVQIDFMPKELVTYSKETQTPVASNQPEEEDDEE 188

  Fly   319 KKKAQAKPGTYVEPEKKPPEMSAQIEMLLNTLEFNQIDSYRDDYSLISSRQV------------- 370
            ....:::|.:....|:|..|:.......|...|..|| .:.:|:.....|.:
Zfish   189 LSVPKSEPASQQLEEEKTQEVEEVHPRELTNEEKEQI-VHSEDFLFFFDRSIRVVERVLAEDKDI 252

  Fly   371 -VQYTNPYLQ----EFLCFANIS---------KSNKRFVAGYDWYPKLSGLIAVSYAFSTPATVN 421
             ..|:...::    :....:|:|         .|..|.|...||.|:...|:..||     .|..
Zfish   253 FFDYSGRDMEDKEGDLQAGSNLSFNRHFYDEHWSKHRVVTSLDWSPQYPELLVASY-----NTNE 312

  Fly   422 EATNRVDYVQRAVLEPNPVLLWSFSDNLNYKLE-----FEAPIETTALTFCPFNGDILLGGSKNG 481
            :|.:..|.|         ||:|    |:.:|..     |.......::.|..|:.::::||:.:|
Zfish   313 DAPHEPDGV---------VLVW----NMKFKKATPEYIFHCQSSVMSVGFAQFHPNLVIGGTYSG 364

  Fly   482 QVVLWDLQGRCEKLDEEEYLTAAQAKYRIMIGEFLNWTIDIEDNVIVPATISLLDCSPKGAITAF 546
            |:.:||.:.......:...|:|....:.:..           .||:.....:.|
Zfish   365 QIAMWDNRSHRRTPVQRTPLSATAHTHPVYC-----------VNVVGTQNANNL----------- 407

  Fly   547 YWLGRSIYLSQFGKVYNDPDIRNHHKFFVTCAFDGTISFWDLDGKGGKSAKDKMRNRMLPKELTQ 611
                                        :|.:.||.:..|.||                  .|:|
Zfish   408 ----------------------------ITVSTDGKMCSWSLD------------------MLSQ 426

  Fly   612 SESAFKSMVIKPTYNLYFPEPITGIIADTSCLSCLTPVAKLIQANPSNYPIKTIAKDPPTMRQSM 676
            .:.:.:.:     ||...|..:|       |::               :|...:        .:.
Zfish   427 PQESMELI-----YNKSKPVAVT-------CMA---------------FPASDV--------NNY 456

  Fly   677 IVSTFYGHVSRIDWQGTYTEGEATEVINSSIPFAMVHDGPVVMVK-KNPFYPELFASIGRT---- 736
            :|.:..|.|......|  ::....|:.:.       |.|||..:. .|...|..|:.:..|
Zfish   457 VVGSEEGTVYTASRHG--SKAGIGEIFDG-------HQGPVTGISCHNAVGPVDFSHLFTTSSFD 512

  Fly   737 -ILAIWKEDYNYSPIF-WRKRACDLTAVAWSETRPAVLYLTRIDGILEAWDILARDDDACLTEIL 799
             .:.:|...:| .|:: :...|..:..|.||...||:......:|.|:.|::....:....:..:
Zfish   513 WTVKLWSTKHN-KPLYSFEDNADYVYDVMWSPVHPALFATVDGNGRLDLWNLNNYTEVPSASVSV 576

  Fly   800 GGGIITAITEHRPSLPHKILGIGDYNSSI------RMVKLPHSFD 838
            .||  .|:...|.:...:.:.:||....:      ..:.:||:.|
Zfish   577 EGG--CALNRVRWASGGREVAVGDSEGRVWIYDVGEQLAVPHTDD 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14838	NP_648138.1	WD40	328..>599	CDD:225201	50/302 (17%)
		WD40 repeat	462..505	CDD:293791	10/42 (24%)
		WD40 repeat	510..547	CDD:293791	3/36 (8%)
		RE_R_Pab1	807..>863	CDD:286594	6/38 (16%)
dync1i1	XP_009290517.1	Dynein_IC2	147..175	CDD:288403	4/27 (15%)
		WD40	215..608	CDD:225201	86/526 (16%)
		WD40	284..607	CDD:295369	77/455 (17%)
		WD40 repeat	292..337	CDD:293791	15/62 (24%)
		WD40 repeat	347..388	CDD:293791	10/40 (25%)
		WD40 repeat	394..437	CDD:293791	12/115 (10%)
		WD40 repeat	443..490	CDD:293791	12/85 (14%)
		WD40 repeat	498..530	CDD:293791	6/32 (19%)
		WD40 repeat	536..574	CDD:293791	8/37 (22%)
		WD40 repeat	582..608	CDD:293791	3/25 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810