DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14838 and dnai4

DIOPT Version :9

Sequence 1:	NP_648138.1	Gene:	CG14838 / 38851	FlyBaseID:	FBgn0035799	Length:	1132	Species:	Drosophila melanogaster
Sequence 2:	NP_001018595.1	Gene:	dnai4 / 553797	ZFINID:	ZDB-GENE-050522-322	Length:	778	Species:	Danio rerio

Alignment Length:	788	Identity:	144/788 - (18%)
Similarity:	266/788 - (33%)	Gaps:	204/788 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 LFDELENSAELMKKFKNFNPEHFILIGFCPLLTEQEDDPPEGEPFI--FYSSIKESKMAMSIIQN 178
            :|..|:.|...|.:|              |.:..|..:.....||.  |:.|...|:::.:....
Zfish    99 VFTALDTSLTTMTEF--------------PSIAFQTTNASLTGPFTRSFFGSASASRISQTAESV 149

  Fly   179 MEHFERWRMQRRLRKKPRRWVSHGTDEEMTIMVERFKDEPID-------VEIQSVYPIQMPRHVA 236
            .:..:...:::.|........||..:.:     |:.::..:|       .|.::::.:.:|   |
Zfish   150 TDETKDLLVKQDLSNSISDIQSHREEPK-----EQLRENILDSTANCYLSETETIWLLDIP---A 206

  Fly   237 FDYRMTRDVRDGVLELLPNENIKWENVTKKR------VNVSVQ--SAPPKIEREQQTNPTFPSNA 293
            ....:..:..:.|.|    .|..:..:.|.|      |..|:|  |..||.:..|..:.|....|
Zfish   207 VSVSLESEDAEAVKE----RNNAYTELCKNRQGNDKYVERSMQTFSDAPKTKEVQCDSITMVDKA 267

  Fly   294 -----WSQYLYEIDDEDLELDETDVDEEEEKKKAQAKP-GTYVEPEKKPPEM------------S 340
                 |..|....:..|:..:.....|..|....::.| |..|.|::....:            |
Zfish   268 VMCTVWDMYDSFNNISDVSANTVVSSERHEATIPESSPEGHLVHPKRSNQSLSVVSTVSTVSGSS 332

  Fly   341 AQIEMLLNTLEFNQIDSYRDDYSLISSRQVVQYTNPYLQEFLCFANISKSNKRFVAGYDWYPKLS 405
            ..||.:...|   .:|...|...::.|.::.|  :..|.|.:..||:.:..   :|.|...|.:.
Zfish   333 THIEKMACVL---PLDEEPDLQLILQSDKLKQ--DLALMERVVLANVFQPK---LAAYRQLPIIE 389

  Fly   406 GLIAVSYAFSTPATVNEATN-RVDYVQRAVLEPNPVLLWSFSDNLNYKLEFEAPIETTALTFCPF 469
            ....|.......:...::.| ...:::|         ||.||      .|.......|.:.:...
Zfish   390 DPDCVQMVMEEESWTEQSKNSHCPFLER---------LWDFS------CELTMGRNVTCMVWNKK 439

  Fly   470 NGDILLGG--------SKNGQVVLWDLQG--------RCEK----LDEEEYLTAAQAKYRIMIGE 514
            |.|:|..|        ..:|.|..|.|:.        .||.    ||    .:|:.|. ::.:|.
Zfish   440 NPDLLAVGYGQVEFKNPNSGLVCCWSLKNPTWPDRVFYCESGVTALD----FSASNAN-QLAVGM 499

  Fly   515 FLNWTI---DIEDNVIVPATISLLDC-----SPKGAITAFYWLGRSIYLSQFGKVYNDPDIRNHH 571
            : :.||   :::.:...|.|.| .||     ||...:|   |:.           :.|....:..
Zfish   500 Y-DGTIAIYNVQTSEQTPITDS-SDCANLHTSPVWQLT---WID-----------HEDGLAADKG 548

  Fly   572 KFFVTCAFDGTISFWDLDGKGGKSAKDKMRNRMLPKELTQSESAFKSM----VIK-PTYNLYFPE 631
            :..|:.:.||.||.|                           ..:|||    ::| ..::|.:.:
Zfish   549 EILVSVSSDGRISKW---------------------------IHYKSMECVDLMKLKIHDLQWKQ 586

  Fly   632 PITGIIADTSCLSCLTPVAKLIQANPSNYPIKTIAKDPPTMRQSMIVSTFYGHVSRIDWQGTYTE 696
            .|          |.||| ......:|::..|             .:|.|..||:.:.  ..:|.|
Zfish   587 HI----------SSLTP-GMCFDFHPNDSKI-------------YLVGTEEGHIHKC--SSSYNE 625

  Fly   697 GEATEVINSSIPFAMVHDGPVVMVKKNPFYPELFASIGRT-ILAIWKEDYNYSPIFWRKRACDLT 760
                :.::|    ...|..||..|..:||..::|.|.... .:.:|::|.....:.:......:.
Zfish   626 ----QYLDS----YKAHKRPVYKVTWSPFCSDVFLSCSSDWTIQLWRQDLQIPVMGFTSGQRVVF 682

  Fly   761 AVAWSETRPAVLYLTRIDGILEAWDILARDDDACLTEILGGGIITAITEHRPSLPHKILGIGDYN 825
            .:.|| ...|.::....:|.:|.||:.....|..|......|:........|.....:  :||..
Zfish   683 DIMWS-PHCATVFGAVSEGKVEIWDLRVSSLDPTLVNWTSPGVNPTALLFSPETDCVL--VGDSE 744

  Fly   826 SSIRMVKL 833
            ..:.:.||
Zfish   745 GQVTVYKL 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14838	NP_648138.1	WD40	328..>599	CDD:225201	59/311 (19%)
		WD40 repeat	462..505	CDD:293791	14/62 (23%)
		WD40 repeat	510..547	CDD:293791	11/44 (25%)
		RE_R_Pab1	807..>863	CDD:286594	5/27 (19%)
dnai4	NP_001018595.1	WD40 repeat	431..473	CDD:293791	9/41 (22%)
		WD40	<459..754	CDD:225201	73/379 (19%)
		WD 1. /evidence=ECO:0000255	477..517		9/45 (20%)
		WD40	479..751	CDD:295369	66/356 (19%)
		WD40 repeat	483..526	CDD:293791	12/49 (24%)
		WD 2. /evidence=ECO:0000255	526..573		14/87 (16%)
		WD40 repeat	531..576	CDD:293791	12/85 (14%)
		WD 3. /evidence=ECO:0000255	586..629		13/72 (18%)
		WD40 repeat	589..624	CDD:293791	10/50 (20%)
		WD 4. /evidence=ECO:0000255	633..673		10/39 (26%)
		WD40 repeat	638..675	CDD:293791	8/36 (22%)
		WD 5. /evidence=ECO:0000255	676..715		8/39 (21%)
		WD40 repeat	681..707	CDD:293791	6/26 (23%)
		WD 6. /evidence=ECO:0000255	721..760		6/34 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810