DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14838 and Dnai2

DIOPT Version :9

Sequence 1:	NP_648138.1	Gene:	CG14838 / 38851	FlyBaseID:	FBgn0035799	Length:	1132	Species:	Drosophila melanogaster
Sequence 2:	NP_001007727.1	Gene:	Dnai2 / 360654	RGDID:	1359602	Length:	619	Species:	Rattus norvegicus

Alignment Length:	750	Identity:	148/750 - (19%)
Similarity:	264/750 - (35%)	Gaps:	241/750 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   250 LELLPNENIKWENVTKKRVNVSVQSAPPKIEREQQTNPTFPSNAWSQYL---YEIDDEDLELDET 311
            :::.||..:....|.:..|:..:|.:....|.|..|......|....::   :..|....||::|
  Rat    29 IDISPNPELAALYVERNPVDTGIQCSASMSEHEANTERFEMENCGVNHVEGGWPKDVNPQELEQT 93

  Fly   312 -----DVDEEEEKKKAQAKPGTYVEPEKKPPEMSAQIEMLLNTLEFNQIDSYR---DDYSLI--- 365
                 .|:::|....|..:.|:.:|...|               :.|.||.|.   ||...:
  Rat    94 IRFRKKVEKDENYINAVMQLGSIMEHCIK---------------QNNAIDIYEEYFDDEEAVEVT 143

  Fly   366 ----SSRQVVQYTNPYLQEFLCFANISKSNKRFVAGYDWYPKLSGLIAVSYAFSTPATVNEATNR 426
                |::.:..:.:|  ||.          ||......|:|..:..:||:|:.
  Rat   144 EEAPSAKTINVFRDP--QEI----------KRTATHLSWHPDGNKKLAVAYSC------------ 184

  Fly   427 VDYVQRAVLEPNPVLLWSFSDNLN---YKLEFEAPIETTALTFCPFNGDILLGGSKNGQVVLWDL 488
            :.:.:..:...:...:|.. :|.|   ..|:..:|:.|  |.:.|.:..:||||..|||:..||.
  Rat   185 LQFQRSPMGMSHDSYIWDL-ENPNRPEIALKPSSPLIT--LEYNPKDSHVLLGGCYNGQIACWDT 246

  Fly   489 QGRCEKLDEEEYLTAAQAKYRIMIGEFLNWTIDIEDNVIVPATISLLDCSPKGAITAFYWLGRSI 553
            :                                 :.:::  |.:|.::.|.:..:....||....
  Rat   247 R---------------------------------KGSLV--AELSTIEFSHRDPVYGTIWLQSKT 276

  Fly   554 YLSQFGKVYNDPDIRNHHKFFVTCAFDGTISFWDLDGKGGKSAK----DKMRNRMLPKELTQSES 614
            ....|                 :.:.||.:.:||: .|..:..:    |..|...|...|.....
  Rat   277 GTECF-----------------SASTDGQVMWWDI-RKISEPTEVVIMDITRKEQLENALGAISL 323

  Fly   615 AFKSMVIKPTYNLYFPEPITGIIADTSCLSCLTPVAKLIQANPSNYPIKTIAKDPPTMRQSMIVS 679
            .|:|.:  ||..:...|  .||:     :||             |...||.|:        .||.
  Rat   324 EFESTL--PTKFMVGTE--QGIV-----ISC-------------NRKAKTPAE--------KIVC 358

  Fly   680 TFYGHVSRIDWQGTYTEGEATEVINSSIPFAMVHDGPVVMVKKNPFYPELFASIGRTILAIWKED 744
            ||.|                             |.||:..:::|||||:.|.::|.....||.|:
  Rat   359 TFSG-----------------------------HHGPIYALQRNPFYPKNFLTVGDWAARIWSEE 394

  Fly   745 YNYSPIFW-RKRACDLTAVAWSETRPAVLYLTRIDGILEAWDILARDDDACLTEILGGGIITAIT 808
            ...|.|.| |.....|:..|||..||||.:.|::||.|:.||::.:..|
  Rat   395 SRESSIMWTRYHMAYLSDGAWSPVRPAVFFTTKMDGTLDIWDLVFKQCD---------------- 443

  Fly   809 EHRPSLPHKI----------------LGIGDYNSSIRMVKLPHSFDVPLPNELDQLIKYVLKEER 857
               |:|..|:                :..|....:..::::..|......||.: :...:.:.|.
  Rat   444 ---PALSLKVCDDPLFCLRVQDTGCLIACGSELGTTTLLEVSSSLSTLQRNERN-IASSIFERET 504

  Fly   858 RKMGI----------------------QSWEQKYYELNKDIIEAKREAAAEIRKEMEKKEKEEQL 900
            |:..|                      |..|:...:|::.:.:|:.|....|..|:::|| .|.|
  Rat   505 RREKILEARHREMRLKEKGKAEGRDDDQKEEETALDLDELVNKAEEEFFEVIFAELKRKE-AEAL 568

  Fly   901 ASRKKGQKSG--EDGGEGGEEIKGKKNYSGLNYNE 933
            ..:.|.:|:.  .:|.:..|:|.|::..||:...|
  Rat   569 KKKPKPKKASIEVEGEDELEDIAGEEEESGIIMGE 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14838	NP_648138.1	WD40	328..>599	CDD:225201	47/287 (16%)
		WD40 repeat	462..505	CDD:293791	11/42 (26%)
		WD40 repeat	510..547	CDD:293791	3/36 (8%)
		RE_R_Pab1	807..>863	CDD:286594	10/93 (11%)
Dnai2	NP_001007727.1	WD40 repeat	165..212	CDD:293791	8/59 (14%)
		WD40	<166..489	CDD:225201	92/468 (20%)
		WD40	166..472	CDD:295369	91/451 (20%)
		WD 1	214..254		13/76 (17%)
		WD40 repeat	220..259	CDD:293791	14/75 (19%)
		WD 2	261..302		9/58 (16%)
		WD40 repeat	266..361	CDD:293791	28/142 (20%)
		WD40 repeat	318..347	CDD:293791	10/50 (20%)
		WD 3	362..401		15/67 (22%)
		WD40 repeat	367..403	CDD:293791	12/35 (34%)
		WD 4	405..445		15/58 (26%)
		WD40 repeat	410..435	CDD:293791	12/24 (50%)
		WD 5	450..489		2/38 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	566..619		10/37 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353522
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56355
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12442
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850