DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14838 and Dync2i2

DIOPT Version :9

Sequence 1:	NP_648138.1	Gene:	CG14838 / 38851	FlyBaseID:	FBgn0035799	Length:	1132	Species:	Drosophila melanogaster
Sequence 2:	NP_001005542.2	Gene:	Dync2i2 / 296618	RGDID:	1359465	Length:	537	Species:	Rattus norvegicus

Alignment Length:	490	Identity:	101/490 - (20%)
Similarity:	161/490 - (32%)	Gaps:	155/490 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   401 YPKL--SGLIAVSYAFSTPATVNE-ATNRVDYVQRAVLEPNPVLLWSFS-DNLN---YKLEFEAP 458
            ||..  .||.....:::|..:|.. |..|:|......|: :.|..|:.. ..||   ..:..|.|
  Rat   155 YPPAQGQGLHVTGISWNTTGSVLACAYGRLDDGDWGTLK-SYVCTWNLDRQGLNPHQPSVVVEVP 218

  Fly   459 IETTALTFCPFNGDILLGGSKNGQVVLWDLQGRCEKLDEEEYLTAAQAKYRIMIGEFLNWTIDIE 523
            .....|.|.|.....:.||..:|:|::||: .|.|                    :.|.|...:.
  Rat   219 SAVMCLAFHPIQPSHIAGGLYSGEVLVWDM-SRPE--------------------DPLLWRTGLT 262

  Fly   524 DNVIVPATISLLDCSPKGAITAFYWLGRSIYLSQFGKVYNDPDIRNHHKFFV-TCAFDGTISFWD 587
            |:........:|            ||               |:.|:.|:|.| :.|.||.:..|.
  Rat   263 DDTHTDPVYQVL------------WL---------------PEPRHSHRFQVLSAATDGRVLLWR 300

  Fly   588 LDGKGGKSAKDKMRNRMLPKELTQSESAFKSMVIKPTYNLYFPEPITGIIADTSCLSCLTPVAKL 652
            ..|.|               :|..|:.                                  .|..
  Rat   301 GSGAG---------------QLRLSKG----------------------------------FALA 316

  Fly   653 IQANPSNYPIKTIAKDPPTMR-----QSMIVSTFYGHVSRIDWQGTY-------TEGEATEVINS 705
            :|    ..|..|..|.||...     .|:..|:|...:..:..:|.:       .|..|...:.|
  Rat   317 VQ----QLPRSTKLKKPPRGETEVGVTSVAFSSFDSSLFVLGTEGGFPLKCSLAAEAAALTRMPS 377

  Fly   706 SIPF-AMV------HDGPVVMVKKNPFYPELFASIGRTILAIWKEDYNYSPIFWRKRACDLT--- 760
            |:|. |.|      |.|||..|..:||:..||.|.|..         .:..::...:|..||
  Rat   378 SVPLRAPVQFTFSPHGGPVYSVSCSPFHRNLFLSAGTD---------GHVHLYSMLQAQPLTSLQ 433

  Fly   761 -------AVAWSETRPAVLYLTRIDGILEAWDI--LARDDDACLTEILGGGIITAITEHRPSLPH 816
                   ||.||..||.|......:|.::.:|:  .::.....:|:...|..:..:..:  |...
  Rat   434 LSHKYLFAVRWSPVRPLVFAAASGEGDVQLFDLQKSSQKPTVSITQTQDGSPVYCLEFN--SQQT 496

  Fly   817 KILGIGDYNSSIRMVKLPHSFDVPLPNE---LDQL 848
            ::|..||....:::.:|..:|....|.|   ||||
  Rat   497 QLLAAGDAKGVVKVWQLSTAFTEQGPREAEDLDQL 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14838	NP_648138.1	WD40	328..>599	CDD:225201	44/205 (21%)
		WD40 repeat	462..505	CDD:293791	11/42 (26%)
		WD40 repeat	510..547	CDD:293791	4/36 (11%)
		RE_R_Pab1	807..>863	CDD:286594	12/45 (27%)
Dync2i2	NP_001005542.2	WD40	101..515	CDD:225201	94/472 (20%)
		WD40 repeat	165..211	CDD:293791	10/46 (22%)
		WD40	218..515	CDD:295369	79/408 (19%)
		WD40 repeat	223..265	CDD:293791	14/62 (23%)
		WD40 repeat	271..309	CDD:293791	15/79 (19%)
		WD40 repeat	339..389	CDD:293791	11/49 (22%)
		WD40 repeat	396..433	CDD:293791	11/45 (24%)
		WD40 repeat	439..479	CDD:293791	9/39 (23%)
		WD40 repeat	486..511	CDD:293791	4/26 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810