DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14838 and Dync1i1

DIOPT Version :9

Sequence 1:	NP_648138.1	Gene:	CG14838 / 38851	FlyBaseID:	FBgn0035799	Length:	1132	Species:	Drosophila melanogaster
Sequence 2:	NP_062107.2	Gene:	Dync1i1 / 29564	RGDID:	2512	Length:	643	Species:	Rattus norvegicus

Alignment Length:	705	Identity:	136/705 - (19%)
Similarity:	239/705 - (33%)	Gaps:	239/705 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 MTR----DVRDGVLELLPNENIKWENVTKKRVN-------VSVQSAPPKI---EREQQTNPTFPS 291
            :||    |....||:|..:..:      .:|:|       ..|...|.::   .:|.||
  Rat   118 LTRTLQWDTDPSVLQLQSDSEL------GRRLNKLGVSKVTQVDFLPREVVSYSKETQT------ 170

  Fly   292 NAWSQYLYEIDDEDLELDETDVDEEEEKKKAQAKPGTYVEPEKKPPEMSAQIEMLLNTLEFNQID 356
             ..:.:..|.|:||.|:.|..|..:.|.:....|..|...|.::..|...|  .:|::.||.
  Rat   171 -PLATHQSEEDEEDEEMVEPKVGHDSELENQDKKQETKEAPPRELTEEEKQ--QILHSEEFL--- 229

  Fly   357 SYRDDYSLISSRQVVQ-------YTNPYLQE----FLCFANIS---------KSNKRFVAGYDW- 400
            .:.|....:..|.:.:       |:...|:|    ....||:|         .|..|.|...||
  Rat   230 IFFDRTIRVIERALAEDSDIFFDYSGRELEEKDGDVQAGANLSFNRQFYDEHWSKHRVVTCMDWS 294

  Fly   401 --YPKLSGLIAVSYAFSTPATVNEATNRVDYVQRAVLEPNPV-LLWSFSDNLNYK-----LEFEA 457
              ||:   |:..||           :|..|    |..||:.| |:|    |:.:|     ..|..
  Rat   295 LQYPE---LMVASY-----------SNNED----APHEPDGVALVW----NMKFKKTTPEYVFHC 337

  Fly   458 PIETTALTFCPFNGDILLGGSKNGQVVLWDLQGRCEKLDEEEYLTAAQAKYRIMIGEFLNWTIDI 522
            .....::.|..|:.::::||:.:||:||||.:.......:...|:||...:.:.
  Rat   338 QSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAAHTHPVY----------- 391

  Fly   523 EDNVIVPATISLLDCSPKGAITAFYWLGRSIYLSQFGKVYNDPDIRNHHKFFVTCAFDGTISFWD 587
                          |                        .|....:|.|. .:|.:.||.:..|.
  Rat   392 --------------C------------------------VNVVGTQNAHN-LITVSTDGKMCSWS 417

  Fly   588 LDGKGGKSAKDKMRNRMLPKELTQSESAFKSMVIKPTYNLYFPEPITGIIADTSCLSCLTPVAKL 652
            ||              ||.   |..||      ::..||...|..:||:...|
  Rat   418 LD--------------MLS---TPQES------MELVYNKSKPVAVTGMAFPT------------ 447

  Fly   653 IQANPSNYPIKTIAKDPPTMRQSMIVSTFYGHVSRIDWQGTYTEGEATEVINSSIPFAMVHDGPV 717
              .:.:|:.:.:         :...|.|...|.|:.. .|...||               |.|||
  Rat   448 --GDVNNFVVGS---------EEGTVYTACRHGSKAG-IGEVFEG---------------HQGPV 485

  Fly   718 VMVK----KNPF-YPELF--ASIGRTILAIWKEDYNYSPIF-WRKRACDLTAVAWSETRPAVLYL 774
            ..:.    ..|. :..||  :|...|: .:|...:| .|:: :...|..:..|.||...||:  .
  Rat   486 TGINCHMAVGPIDFSHLFVTSSFDWTV-KLWTTKHN-KPLYSFEDNADYVYDVMWSPVHPAL--F 546

  Fly   775 TRIDGI--LEAWDILARDDDACLTEILGGGIITAITEHRPSLPHKILGIGDYNSSIRM-----VK 832
            ..:||:  |:.|::.:..:....:..:.|.  :|:...|.:...|.:.:||....|.:     :.
  Rat   547 ACVDGMGRLDLWNLNSDTEVPTASVAIEGA--SALNRVRWAQGGKEVAVGDSEGRIWIYDVGELA 609

  Fly   833 LPHSFDVPLPNELDQLIKYVLKEERRKMGIQSWEQKYYELNKDIIEAKREAAAEI 887
            :||:         |:..::.              :...|:..:..:::.|.|.|:
  Rat   610 VPHN---------DEWTRFA--------------RTLVEIRANRADSEEEGAVEL 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14838	NP_648138.1	WD40	328..>599	CDD:225201	59/299 (20%)
		WD40 repeat	462..505	CDD:293791	12/42 (29%)
		WD40 repeat	510..547	CDD:293791	1/36 (3%)
		RE_R_Pab1	807..>863	CDD:286594	8/60 (13%)
Dync1i1	NP_062107.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..65
		Interaction with DCTN1	2..123		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..123		2/4 (50%)
		Dynein_IC2	145..171	CDD:402922	5/32 (16%)
		Interaction with DYNLT1. /evidence=ECO:0000250\|UniProtKB:O14576	145..161		2/15 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	167..219		15/58 (26%)
		WD40	281..604	CDD:421866	92/462 (20%)
		WD 1	283..332		20/70 (29%)
		WD40 repeat	289..335	CDD:293791	17/67 (25%)
		WD 2	336..376		10/39 (26%)
		WD40 repeat	344..383	CDD:293791	11/38 (29%)
		WD 3	385..426		13/107 (12%)
		WD40 repeat	391..432	CDD:293791	15/113 (13%)
		WD 4	435..475		9/63 (14%)
		WD40 repeat	440..479	CDD:293791	9/62 (15%)
		WD 5	480..525		13/61 (21%)
		WD40 repeat	486..527	CDD:293791	8/42 (19%)
		WD 6	528..568		10/41 (24%)
		WD40 repeat	533..571	CDD:293791	9/39 (23%)
		WD 7	574..613		8/40 (20%)
		WD40 repeat	579..605	CDD:293791	5/25 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810