DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14838 and Dnai3

DIOPT Version :9

Sequence 1:	NP_648138.1	Gene:	CG14838 / 38851	FlyBaseID:	FBgn0035799	Length:	1132	Species:	Drosophila melanogaster
Sequence 2:	NP_001128208.1	Gene:	Dnai3 / 292165	RGDID:	1563105	Length:	921	Species:	Rattus norvegicus

Alignment Length:	1066	Identity:	228/1066 - (21%)
Similarity:	415/1066 - (38%)	Gaps:	264/1066 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 APLSSRRSKPYFKKFKEPDSDEDVADPRQLFNVQESWRTLMSLSSCQKVMVSEKAQKALKIEVGI 96
            :|...|:.|   ||.|:.....:..:|..:    ||    |.......::::.|.|:.....:..
  Rat     8 SPKGQRKGK---KKTKQQSLVSEEEEPMNM----ES----MGHPEIYPLVLTAKTQEIFNCRIDE 61

  Fly    97 NVTQEFPWKQVQFKDLRDVLFDELENSA------------------ELM----KKFK---NF--- 133
            ::|.|..:|.::.:|    :..:|:|.|                  ||:    |.||   ||
  Rat    62 DMTDEQTYKLIKKED----ILADLQNRAAVSDFHPVKKIVLEYPGEELLLVYDKDFKYGLNFYLI 122

  Fly   134 ----NPEHFILIGFCPLLTEQEDDPPEGEPFIFYSSIKESKMAMSIIQNMEHFERWRMQRRLRKK 194
                ..|:|:.   .|.:.|:::|..|..|...|                           :.|.
  Rat   123 GTEEGKENFLK---APEIPEEQEDLKEHVPEDVY---------------------------IYKP 157

  Fly   195 P--RRWVSHGTDEEMTIMVERFKDEPIDVEIQSV-YPIQMPRH-----VAFDYRMTRDVRDGVLE 251
            |  :.|:|.|:::|:       ::|.:....:.| |.|...|.     |.|..:....|:|..:|
  Rat   158 PVSKPWISLGSEKEI-------EEESVQESKKRVTYMISRKRSQFGAPVTFRDQNASSVKDAYIE 215

  Fly   252 L--LPNENIKWENVTKKRVNVSVQSAPPKIEREQQTNPTFPSNAWSQYLYEIDDEDLELDETDVD 314
            .  .|:::.....|.|   ::.:|......:...||...||.||.:||.           ..:..
  Rat   216 CTSYPDKSYTLTQVEK---DIGLQVIAEVKDTSTQTRWAFPRNATTQYY-----------PREFS 266

  Fly   315 EEEEKKKAQAKP-GTYVEPEKKPPEMSAQIEMLLNTLEFNQIDSYRDDYSLISSRQVV--QYTNP 376
            |||:....::|. ..:........|::.|...::||        :.||:..::..:..  ..|:.
  Rat   267 EEEKNVLVESKSLAEFFSTVSTSVEIALQQNEIMNT--------FTDDWRSLAEEESTFGDKTDT 323

  Fly   377 YLQEFLCFANISKSNKRFVAGYDWYPKLSGLIAVSYAFSTPATVNEATNRVDYVQRAVLEPNPVL 441
            :|:|:..|.::..:.::.:....|:|.:.|||.||.|...     ....||....|.:|:|:.:|
  Rat   324 HLKEYQSFTDLHNTMEKMITCVSWHPTIYGLIVVSVAVRL-----SYEERVQNSSRLLLQPSLIL 383

  Fly   442 LWSFSDNLNYKLEFEAPIETTALTFCPFNGDILLGGSKNGQVVLWDLQGRCEKLDEEEYLTAAQA 506
            .|||||.::.:|..|:|.:.....|||.:.:|:.||..|||::|||:....|:: |......:::
  Rat   384 FWSFSDPIHPQLMLESPDDIFCFEFCPSDPNIIAGGCINGQIILWDITAHAERI-ENIKTGGSRS 447

  Fly   507 KYRIMIGEFLNWTIDIEDN----VIVPATISLLDCSPKGAITAFYWLGRSIYLSQFGKVYNDPDI 567
            |...:...||   ::.:.|    .:....:|.::...:..||..:||..|..:::.|.|:.:...
  Rat   448 KKATLKPMFL---LEPDSNKEIMYVRHCAVSSIENGHRKVITDIHWLPDSFEINRMGSVFENRSG 509

  Fly   568 RNHHKFFVTCAFDGTISFWDL--------DGKGGKSAKDKMRNRMLPKELTQSESAFKSMVIKPT 624
            .|..  .:||:.|.||.|||:        ......:......|...|....:.|.:.:.....|:
  Rat   510 INCQ--LITCSADCTICFWDIRPQKPTVTSAATATTTSTTNTNPQQPPAEKKKEESIEIPFDVPS 572

  Fly   625 YNLYFP---EPITGI---IADTSCLSCLTPVA----------------------------KLIQA 655
            ..|:..   :|::.|   ..:||...|.|.::                            ||::|
  Rat   573 TFLHLDLSWKPLSRIKLSKGETSLDHCPTKLSLGEDPALCKIQGTSSIHVLLRDKMLSQMKLLKA 637

  Fly   656 NPSNYPIKTI-------AKDPPTMRQSMIVSTFYGHVSRIDWQGTYTEGEATEVINSSIPFAMVH 713
            ...| |.:.:       .|.....|....|.|..|.|...||:..........:....:....||
  Rat   638 AEIN-PYQNLEGGMANMLKPIEDFRTKFFVGTEEGEVIYTDWKMERDSETGRLMAKKPVNLYTVH 701

  Fly   714 DGPVVMVKKNPFYPELFASIGRTILAIWKEDYNYSPIFWRKRAC---DLTAVAWSETRPAVLYLT 775
            ||.|..|:::||:.::..::|...:|||||:....|:.  :..|   ..||..||.|||.|.|:.
  Rat   702 DGAVHTVQRSPFFNDIILTVGGWNVAIWKEEVLTGPLL--QTCCAPKRYTAGHWSLTRPGVFYIG 764

  Fly   776 RIDGILEAWDILARDDDACLTEILGGGIITAITEHRP---SLPHKILGIGDYNSSIRMVKLPHSF 837
            |.||.::.||:|.:..:...::.:   .||.||..:|   |...:.:.|.||..::.::::|.:.
  Rat   765 REDGYVDIWDLLEKTHEPAQSQSI---CITMITYIKPWTFSSKQQFIAIADYYGTLHILEIPWTL 826

  Fly   838 DVPLPNELDQLIKYVLKEERRKMGIQSWEQKYYELNKDIIEAKREAAAEIRKEMEKKEKEEQLAS 902
            ..|..||:.. :.|..:.|.:.:       :|.:..|:|.|.:::|.|   .||.||:.:
  Rat   827 SHPSTNEVSS-VNYYFEREVKHL-------EYVQQRKEIREEEKKAMA---MEMIKKKAK----- 875

  Fly   903 RKKGQKSGEDGGEGGEEIKGKKNYSGLNYNEKMAVKWDELNLNRMMTILMSRKQMDPE-KLARET 966
                                                          |...|::||:.| ||..|:
  Rat   876 ----------------------------------------------TYHRSKEQMEAELKLEYES 894

  Fly   967 ALEKERHAY------EAAKKKSHLDI 986
            .||.|:...      :.::|.|:||:
  Rat   895 YLELEQSVLFALGLGKVSEKMSYLDL 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14838	NP_648138.1	WD40	328..>599	CDD:225201	67/284 (24%)
		WD40 repeat	462..505	CDD:293791	14/42 (33%)
		WD40 repeat	510..547	CDD:293791	6/40 (15%)
		RE_R_Pab1	807..>863	CDD:286594	13/58 (22%)
Dnai3	NP_001128208.1	WD40	207..>532	CDD:225201	86/357 (24%)
Dnai3	NP_001128208.1	WD40	479..527	CDD:197651	14/49 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	181	1.000	Domainoid score	I3378
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44922
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3880
OMA	1	1.010	-	-		QHG56355
OrthoDB	1	1.010	-	-		D176332at33208
OrthoFinder	1	1.000	-	-		FOG0005463
OrthoInspector	1	1.000	-	-		oto95753
orthoMCL	1	0.900	-	-		OOG6_104391
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.740