DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14838 and Dync2i1

DIOPT Version :9

Sequence 1:	NP_648138.1	Gene:	CG14838 / 38851	FlyBaseID:	FBgn0035799	Length:	1132	Species:	Drosophila melanogaster
Sequence 2:	XP_006515843.1	Gene:	Dync2i1 / 217935	MGIID:	2445085	Length:	1033	Species:	Mus musculus

Alignment Length:	979	Identity:	176/979 - (17%)
Similarity:	290/979 - (29%)	Gaps:	367/979 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 STTDIEVPGKSEIDGDLEGLPIDSEVTDVAAPLSSRRSKPYFKK--FKE---------------- 48
            |.:|.||..:.......|||..|.|.....|....|.||...||  .||
Mouse   284 SLSDREVEDRHREKRHKEGLHYDDERRRSHADKKERSSKEEHKKRELKELEKEDNDLEATGPDEY 348

  Fly    49 -PDSDEDVADPRQLFNVQESWRTLMSLSSCQKVMVSEKAQKALKIEVGINVTQEFPWKQV-QFKD 111
             |:.::|..|....|.|.:.     ...|..:....|||             :|.|..|. :.::
Mouse   349 LPNLEDDFVDYEDDFEVCDG-----DDDSNNEHEAREKA-------------EELPLAQKREIQE 395

  Fly   112 LRDVLFDELENSAEL-MKKFK-----NFNPEHFILIGFCPLLTEQEDDP---PEGEPFIFYSSIK 167
            ::..:..|.|...|| :|.|:     .:..|.:         |:..|.|   |....|:.:::
Mouse   396 IQKAISAENERVGELSLKMFQKQGWTEYTKEPW---------TDANDSPSRTPVCGIFVDFAT-- 449

  Fly   168 ESKMAMSIIQNMEHFERWRMQRRLRKKPRRWVSHGTDEEMTIMVERFKDEPIDVEIQSVYPIQMP 232
                       ..|.::.|.| .|::|.|                               ..::.
Mouse   450 -----------ASHRQKSRSQ-ALKQKTR-------------------------------SSKLL 471

  Fly   233 RHVAFDYRMTRDVRDGVLELLP-NE-NIKWENVTKKRVNVS-VQSAPPKIEREQQTNPTFPSNAW 294
            |.:..|:..|    ..:|:|.| || ::...|..||....: ||.....:||:.||........|
Mouse   472 RLIDLDFSFT----FSLLDLPPVNEYDMYIRNFGKKNTKQAYVQYNEDNVERDIQTEDIETREVW 532

  Fly   295 SQYLYE---IDDEDLELDETDVDEEEEKKKAQAKPGTYVEPEKKPPEMSAQIEMLLNTLEFNQID 356
            :|:..|   :.....|.|.:||.               |.|:...|.       |.|.|
Mouse   533 TQHPGEGTAVSGGSEEKDFSDVT---------------VVPKIDTPR-------LANFL------ 569

  Fly   357 SYRDDYSLISSRQVVQYTNPYLQEFLCFANISKSNKRFVAGYDWYPKLSGLIAVSYAFSTPATVN 421
                       |...|.....|:|           .|..||..|.|:     |...|.:...:.:
Mouse   570 -----------RAACQVVAVLLEE-----------DRLAAGPSWIPR-----AQDKALNISDSSS 607

  Fly   422 EATNRVDYVQ--------------RAVLEPNPVLLWSFSDNLNYK-----------------LEF 455
            :....:.::|              :.|:..:.:...:|:.:|:.:                 |..
Mouse   608 QLNTSLPFLQSRKVSCLHASRVQRQTVVSVHDLPEKAFAPSLDSRHLLCVWDIWQPSGPQKVLIC 672

  Fly   456 EAPIETTALTFCPFNGDILLGGSKNGQVVLWDLQGRCEKLDEEEYLTAAQAKYRIMIGEFLNWTI 520
            |:.:  |...|.|....:|..|:.:|.||:|||:   |......|:..:...:......|..
Mouse   673 ESKV--TCCCFSPLKAFLLFAGTVHGSVVVWDLR---EDSRIHHYVRLSNCFWAFRTPTFST--- 729

  Fly   521 DIEDNVIVPATISLLDCSPKGAI----TAFYWLGRSIYLSQFGKVYNDPDIRNHHKFFVTCAFD- 580
               |.::.    |:...||..||    |:.| ..:|..||.|........:..|     ..:.|
Mouse   730 ---DGILT----SVNHRSPLQAIEPVATSAY-KKQSFVLSPFSTQEEMAGLSFH-----IASLDE 781

  Fly   581 -GTISFW--------DLDGK--------GGKSAKDKMRNRMLPKELTQSESAFKSMVIKPTYNLY 628
             |.::.|        |:.|.        ||:..........|...|:..:|.
Mouse   782 TGVLNVWVVVELPKADISGSMSDLGLIPGGRIKLVHSTVIQLGNSLSHKDSE------------- 833

  Fly   629 FPEPITGIIADTSCLSCLTPVAKLIQANPSNYPIKTIAKDPPTMRQSMIVSTFYG---HVSRIDW 690
                   :...|..||     .|.:.::|:::                :|.|..|   |.:|.||
Mouse   834 -------LWGSTQTLS-----VKFLPSDPNHF----------------VVGTDMGLISHSTRQDW 870

  Fly   691 QGTYTEGEATEVINSSIPFAMVHDGPVVMVKKNPFYPEL------------FASIGRTILAIWKE 743
            :                            |....|.||.            |:....|:......
Mouse   871 R----------------------------VSPRVFKPEQHGVRPIKVNVIDFSPFEETVFLAGCS 907

  Fly   744 D--------YNYSPIF-WRKRACD--LTAVAWSETRPAVLYLTRIDGILEAWDILARDDDACLTE 797
            |        .:..||. |......  :|::.||.|||||..:......:..||:|..|
Mouse   908 DGSIRLHQLTSERPIMQWDNSTSGHAVTSLQWSPTRPAVFLVQDDASRIYVWDLLEND------- 965

  Fly   798 ILGGGIITAITEHRPSLPHKILGI----------GDY--------NSSIRMVKLPHSFDVPLPNE 844
             ||.      ...:|..|.|::.:          |.:        :.::.:..|...:..|..:|
Mouse   966 -LGP------VAQQPISPDKLVAMTIVGEPEKTSGSFVALVLARTSGTVDVQNLKRRWTTPAVDE 1023

  Fly   845 LDQL 848
            ..||
Mouse  1024 HSQL 1027

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14838	NP_648138.1	WD40	328..>599	CDD:225201	57/323 (18%)
		WD40 repeat	462..505	CDD:293791	13/42 (31%)
		WD40 repeat	510..547	CDD:293791	8/40 (20%)
		RE_R_Pab1	807..>863	CDD:286594	9/60 (15%)
Dync2i1	XP_006515843.1	PTZ00121	<48..396	CDD:173412	29/129 (22%)
		WD40	604..1000	CDD:225201	83/499 (17%)
		WD40 repeat	635..671	CDD:293791	2/35 (6%)
		WD40 repeat	676..708	CDD:293791	12/36 (33%)
		WD40 repeat	715..752	CDD:293791	8/46 (17%)
		WD40 repeat	759..788	CDD:293791	6/33 (18%)
		WD40 repeat	842..878	CDD:293791	11/84 (13%)
		WD40 repeat	890..926	CDD:293791	5/35 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900