DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14838 and DYNC1I2

DIOPT Version :9

Sequence 1:	NP_648138.1	Gene:	CG14838 / 38851	FlyBaseID:	FBgn0035799	Length:	1132	Species:	Drosophila melanogaster
Sequence 2:	NP_001258714.1	Gene:	DYNC1I2 / 1781	HGNCID:	2964	Length:	638	Species:	Homo sapiens

Alignment Length:	834	Identity:	155/834 - (18%)
Similarity:	280/834 - (33%)	Gaps:	264/834 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 DELENSAELMKKFKNFNPEHFILIGFCPLLTEQEDDPPEGEPFIFYSSIKESKMAMSIIQNMEHF 182
            |:.|..|||.:|.:.              |.:..::....|.........:.|.|::.:|
Human     3 DKSELKAELERKKQR--------------LAQIREEKKRKEEERKKKETDQKKEAVAPVQ----- 48

  Fly   183 ERWRMQRRLRKKPRRWVSHG-TDEEMTIMVERFKDEPIDVEIQSVYPIQMPRHVAFDYRMTRDVR 246
            |...::::.|:......|.| |.|...:..|.:...|:....:||   ..|....     ::|..
Human    49 EESDLEKKRREAEALLQSMGLTPESPIVFSEYWVPPPMSPSSKSV---STPSEAG-----SQDSG 105

  Fly   247 DGVLELLPNENIKWE---NVTKKRVNVSVQSAPPKIEREQQTNPTFPSNAWSQYLYEI------- 301
            ||.   :.:..:.|:   :|.:...:..:...|.|:...:.|...||......|..|.
Human   106 DGA---VGSRTLHWDTDPSVLQLHSDSDLGRGPIKLGMAKITQVDFPPREIVTYTKETQTPVMAQ 167

  Fly   302 ------DDEDLELDETDVDEEEEK--KK-----AQAKPGTYVEPEKKPPEMSAQIEMLLNTLEFN 353
                  :|:|:...:..::.||||  ||     ::|.|....|.||         :.:|::.||.
Human   168 PKEDEEEDDDVVAPKPPIEPEEEKTLKKDEENDSKAPPHELTEEEK---------QQILHSEEFL 223

  Fly   354 QIDSYRDDYSLISSRQVVQYTNPYLQ-----------EFLCFANISK---------SNKRFVAGY 398
               |:.|..:.|..|.:.:..|.:..           |....|.:|.         |..|.|:..
Human   224 ---SFFDHSTRIVERALSEQINIFFDYSGRDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCL 285

  Fly   399 DWYPKLSGLIAVSYAFSTPATVNEATNRVDYVQRAVLEPNPV-LLWSFSDNLNYK-----LEFEA 457
            ||..:...|:..||           .|..|    |..||:.| |:|    |:.||     ..|..
Human   286 DWSSQYPELLVASY-----------NNNED----APHEPDGVALVW----NMKYKKTTPEYVFHC 331

  Fly   458 PIETTALTFCPFNGDILLGGSKNGQVVLWDLQGRCEKLDEEEYLTAAQAKYRIMIGEFLNWTIDI 522
            .....:.||..|:.::::||:.:||:||||.:.......:...|:||...:.:.
Human   332 QSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVY----------- 385

  Fly   523 EDNVIVPATISLLDCSPKGAITAFYWLGRSIYLSQFGKVYNDPDIRNHHKFFVTCAFDGTISFWD 587
                          |                        .|....:|.|. .::.:.||.|..|.
Human   386 --------------C------------------------VNVVGTQNAHN-LISISTDGKICSWS 411

  Fly   588 LDGKGGKSAKDKMRNRMLPKELTQSESAFKSMVIKPTYNLYFPEPITGIIADTSCLSCLTPVAKL 652
            ||..  ...:|.|       ||...:|                                    |.
Human   412 LDML--SHPQDSM-------ELVHKQS------------------------------------KA 431

  Fly   653 IQANPSNYPIKTIAKDPPTMRQSMIVSTFYGHVSRIDWQGTYTEGEATEVINSSIPFAMVHDGPV 717
            :.....::|:..:        .:.:|.:..|.|......|  ::...:|:...       |.||:
Human   432 VAVTSMSFPVGDV--------NNFVVGSEEGSVYTACRHG--SKAGISEMFEG-------HQGPI 479

  Fly   718 VMVKKNPF-----YPELF--ASIGRTILAIWKEDYNYSPIF-WRKRACDLTAVAWSETRPAVLYL 774
            ..:..:..     :..||  :|...|: .:|... |..|:: :...|..:..|.||.|.||:  .
Human   480 TGIHCHAAVGAVDFSHLFVTSSFDWTV-KLWTTK-NNKPLYSFEDNADYVYDVMWSPTHPAL--F 540

  Fly   775 TRIDGI--LEAWDILARDDDACLTEILGGGIITAITEHRPSLPHKILGIGDYNSSIRMVKLPHS- 836
            ..:||:  |:.|::   ::|   ||:             |:....:.|    |.::..|:..||
Human   541 ACVDGMGRLDLWNL---NND---TEV-------------PTASISVEG----NPALNRVRWTHSG 582

  Fly   837 FDVPLPNELDQLIKYVLKEERRKMGIQSWE---QKYYELNKDIIEAKREAAAEI 887
            .::.:.:...|::.|.:.|:........|.   :...|:|.:..:|:.|||..|
Human   583 REIAVGDSEGQIVIYDVGEQIAVPRNDEWARFGRTLAEINANRADAEEEAATRI 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14838	NP_648138.1	WD40	328..>599	CDD:225201	58/296 (20%)
		WD40 repeat	462..505	CDD:293791	13/42 (31%)
		WD40 repeat	510..547	CDD:293791	1/36 (3%)
		RE_R_Pab1	807..>863	CDD:286594	9/56 (16%)
DYNC1I2	NP_001258714.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..135		27/161 (17%)
		Dynein_IC2	135..163	CDD:402922	7/27 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..214		15/67 (22%)
		WD 1	277..326		19/67 (28%)
		WD40 repeat	282..331	CDD:293791	18/67 (27%)
		WD40	329..>599	CDD:225201	69/408 (17%)
		WD 2	330..370		11/39 (28%)
		WD40 repeat	339..377	CDD:293791	12/37 (32%)
		WD 3	379..420		10/92 (11%)
		WD40 repeat	385..426	CDD:293791	14/99 (14%)
		WD 4	429..469		7/85 (8%)
		WD40 repeat	434..481	CDD:293791	9/63 (14%)
		WD 5	474..519		10/53 (19%)
		WD40 repeat	489..521	CDD:293791	7/33 (21%)
		WD 6	522..562		14/60 (23%)
		WD40 repeat	527..565	CDD:293791	14/58 (24%)
		WD 7	568..607		8/42 (19%)
		WD40 repeat	573..599	CDD:293791	5/25 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810