DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mmm and DYNC1I2

DIOPT Version :10

Sequence 1:NP_648138.1 Gene:mmm / 38851 FlyBaseID:FBgn0035799 Length:1132 Species:Drosophila melanogaster
Sequence 2:NP_001369.1 Gene:DYNC1I2 / 1781 HGNCID:2964 Length:638 Species:Homo sapiens


Alignment Length:834 Identity:155/834 - (18%)
Similarity:280/834 - (33%) Gaps:264/834 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   118 DELENSAELMKKFKNFNPEHFILIGFCPLLTEQEDDPPEGEPFIFYSSIKESKMAMSIIQNMEHF 182
            |:.|..|||.:|.:.              |.:..::....|.........:.|.|::.:|     
Human     3 DKSELKAELERKKQR--------------LAQIREEKKRKEEERKKKETDQKKEAVAPVQ----- 48

  Fly   183 ERWRMQRRLRKKPRRWVSHG-TDEEMTIMVERFKDEPIDVEIQSVYPIQMPRHVAFDYRMTRDVR 246
            |...::::.|:......|.| |.|...:..|.:...|:....:||   ..|....     ::|..
Human    49 EESDLEKKRREAEALLQSMGLTPESPIVFSEYWVPPPMSPSSKSV---STPSEAG-----SQDSG 105

  Fly   247 DGVLELLPNENIKWE---NVTKKRVNVSVQSAPPKIEREQQTNPTFPSNAWSQYLYEI------- 301
            ||.   :.:..:.|:   :|.:...:..:...|.|:...:.|...||......|..|.       
Human   106 DGA---VGSRTLHWDTDPSVLQLHSDSDLGRGPIKLGMAKITQVDFPPREIVTYTKETQTPVMAQ 167

  Fly   302 ------DDEDLELDETDVDEEEEK--KK-----AQAKPGTYVEPEKKPPEMSAQIEMLLNTLEFN 353
                  :|:|:...:..::.||||  ||     ::|.|....|.||         :.:|::.||.
Human   168 PKEDEEEDDDVVAPKPPIEPEEEKTLKKDEENDSKAPPHELTEEEK---------QQILHSEEFL 223

  Fly   354 QIDSYRDDYSLISSRQVVQYTNPYLQ-----------EFLCFANISK---------SNKRFVAGY 398
               |:.|..:.|..|.:.:..|.:..           |....|.:|.         |..|.|:..
Human   224 ---SFFDHSTRIVERALSEQINIFFDYSGRDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCL 285

  Fly   399 DWYPKLSGLIAVSYAFSTPATVNEATNRVDYVQRAVLEPNPV-LLWSFSDNLNYK-----LEFEA 457
            ||..:...|:..||           .|..|    |..||:.| |:|    |:.||     ..|..
Human   286 DWSSQYPELLVASY-----------NNNED----APHEPDGVALVW----NMKYKKTTPEYVFHC 331

  Fly   458 PIETTALTFCPFNGDILLGGSKNGQVVLWDLQGRCEKLDEEEYLTAAQAKYRIMIGEFLNWTIDI 522
            .....:.||..|:.::::||:.:||:||||.:.......:...|:||...:.:.           
Human   332 QSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVY----------- 385

  Fly   523 EDNVIVPATISLLDCSPKGAITAFYWLGRSIYLSQFGKVYNDPDIRNHHKFFVTCAFDGTISFWD 587
                          |                        .|....:|.|. .::.:.||.|..|.
Human   386 --------------C------------------------VNVVGTQNAHN-LISISTDGKICSWS 411

  Fly   588 LDGKGGKSAKDKMRNRMLPKELTQSESAFKSMVIKPTYNLYFPEPITGIIADTSCLSCLTPVAKL 652
            ||..  ...:|.|       ||...:|                                    |.
Human   412 LDML--SHPQDSM-------ELVHKQS------------------------------------KA 431

  Fly   653 IQANPSNYPIKTIAKDPPTMRQSMIVSTFYGHVSRIDWQGTYTEGEATEVINSSIPFAMVHDGPV 717
            :.....::|:..:        .:.:|.:..|.|......|  ::...:|:...       |.||:
Human   432 VAVTSMSFPVGDV--------NNFVVGSEEGSVYTACRHG--SKAGISEMFEG-------HQGPI 479

  Fly   718 VMVKKNPF-----YPELF--ASIGRTILAIWKEDYNYSPIF-WRKRACDLTAVAWSETRPAVLYL 774
            ..:..:..     :..||  :|...|: .:|... |..|:: :...|..:..|.||.|.||:  .
Human   480 TGIHCHAAVGAVDFSHLFVTSSFDWTV-KLWTTK-NNKPLYSFEDNADYVYDVMWSPTHPAL--F 540

  Fly   775 TRIDGI--LEAWDILARDDDACLTEILGGGIITAITEHRPSLPHKILGIGDYNSSIRMVKLPHS- 836
            ..:||:  |:.|::   ::|   ||:             |:....:.|    |.::..|:..|| 
Human   541 ACVDGMGRLDLWNL---NND---TEV-------------PTASISVEG----NPALNRVRWTHSG 582

  Fly   837 FDVPLPNELDQLIKYVLKEERRKMGIQSWE---QKYYELNKDIIEAKREAAAEI 887
            .::.:.:...|::.|.:.|:........|.   :...|:|.:..:|:.|||..|
Human   583 REIAVGDSEGQIVIYDVGEQIAVPRNDEWARFGRTLAEINANRADAEEEAATRI 636

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mmmNP_648138.1 WD40 repeat 462..505 CDD:293791 13/42 (31%)
WD40 repeat 510..547 CDD:293791 1/36 (3%)
DYNC1I2NP_001369.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..135 27/161 (17%)
Dynein_IC2 133..163 CDD:463291 7/29 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 155..214 15/67 (22%)
WD 1 277..326 19/67 (28%)
WD40 repeat 282..331 CDD:293791 18/67 (27%)
WD40 <310..413 CDD:441893 29/156 (19%)
WD 2 330..370 11/39 (28%)
WD40 repeat 339..377 CDD:293791 12/37 (32%)
WD 3 379..420 10/92 (11%)
WD40 380..>605 CDD:475233 55/363 (15%)
WD40 repeat 385..426 CDD:293791 14/99 (14%)
WD 4 429..469 7/85 (8%)
WD40 repeat 434..481 CDD:293791 9/63 (14%)
WD 5 474..519 10/53 (19%)
WD40 repeat 489..521 CDD:293791 7/33 (21%)
WD 6 522..562 14/60 (23%)
WD40 repeat 527..565 CDD:293791 14/58 (24%)
WD 7 568..607 8/42 (19%)
WD40 repeat 573..599 CDD:293791 5/25 (20%)

Return to query results.
Submit another query.